LABORATORY RESEARCH Cell Autonomous Role of PTEN in Regulating Castration-Resistant Prostate Cancer Growth Researchers showed that castration-resistant growth is an intrinsic property of Pten null prostate cancer cells, independent of cancer development stage. [Cancer Cell] B Regulatory Cells and the Tumor-Promoting Actions of TNF-α During Squamous Carcinogenesis Because B cells regulate squamous and prostate carcinogenesis, and Tnf−/− mice harbor B-cell defects, scientists investigated the hypothesis that B cells are important effector cells for TNF-α–mediated promotion of cancer development. [Proc Natl Acad Sci U S A] Plasma Membrane-Associated Sialidase (NEU3) Regulates Progression of Prostate Cancer to Androgen-Independent Growth through Modulation of Androgen Receptor Signaling To understand the underlying mechanisms and facilitate the development of novel treatments for androgen-independent prostate cancer, researchers have investigated plasma membrane-associated sialidase (NEU3), the key enzyme for ganglioside hydrolysis participating in transmembrane signaling. [Cell Death Differ] BMP4 Promotes Prostate Tumor Growth in Bone through Osteogenesis To identify the factors that are involved in bone formation, scientists compared the expression of secreted factors from MDA-PCa-118b and MDA-PCa-133 by cytokine array. [Cancer Res] Inactivation of AR/TMPRSS2-ERG/Wnt Signaling Networks Attenuates the Aggressive Behavior of Prostate Cancer Cells Researchers found that because BR-DIM and CDF down-regulate multiple signaling pathways including androgen receptor (AR)/TMPRSS2-ERG/Wnt signaling, these agents could be useful for designing novel strategies for the prevention and/or treatment of prostate cancer. [Cancer Prev Res] Abnormal Expression of the ERG Transcription Factor in Prostate Cancer Cells Activates Osteopontin This study was designed to test whether ERG and the product of the TMPRSS2:ERG fusion gene modulate osteopontin gene expression in prostate cancer cells. [Mol Cancer Res] PEDF and MDA-7 Cytokine Gene Therapies Delivered by Adipose-Derived Mesenchymal Stem Cells Are Effective in Reducing Prostate Cancer Cell Growth The researchers’ goal was to examine the potential of adipose-derived mesenchymal stem cell to deliver cytokine gene therapies MDA-7 (melanoma differentiation associated gene-7) or PEDF (pigment epithelial-derived factor) to cancer cells. [Stem Cells Dev] Normal Prostate-Derived Stromal Cells Stimulate Prostate Cancer Development In this study, investigators assessed the significance of normal prostate-derived stromal cells in prostate cancer development. [Cancer Sci] CLINICAL RESEARCH Circulating Tumor Cells from Patients with Advanced Prostate and Breast Cancer Display Both Epithelial and Mesenchymal Markers Researchers showed that the existence and high frequency of circulating tumor cells (CTCs) co-expressing epithelial, mesenchymal, and stem-cell markers in patients with progressive metastases has important implications for the application and interpretation of approved methods to detect CTCs. [Mol Cancer Res] Serum Estrogen Levels and Prostate Cancer Risk in the Prostate Cancer Prevention Trial: A Nested Case-Control Study Study’s findings confirmed those from previous studies that there are no associations of serum estrogen with prostate cancer risk in untreated men. In addition, finasteride results in a modest increase in serum estrogen levels, which are not related to prostate cancer risk. Whether finasteride is less effective in men with high serum estrogens, or finasteride interacts with estrogen to increase cancer risk, is uncertain and warrants further investigation. [Cancer Causes Control] |