LABORATORY RESEARCH Noninvasive Measurement of Androgen Receptor Signaling with a Positron-Emitting Radiopharmaceutical that Targets Prostate-Specific Membrane Antigen Results establish that relative changes in prostate-specific membrane antigen expression levels can be quantitatively measured using a human-ready imaging reagent and could serve as a biomarker of androgen receptor (AR) signaling to noninvasively evaluate AR activity in patients with castration-resistant prostate cancer. [Proc Natl Acad Sci U S A] Combination of P13K/mTOR Inhibitors: Antitumor Activity and Molecular Correlates The PI3K/Akt/mTOR pathway is a major target for cancer therapy. As a strategy to induce the maximal inhibition of this pathway in cancer cells, researchers combined allosteric mTOR inhibitors (rapamycin and RAD001) with a dual PI3K/mTOR kinase inhibitor. [Cancer Res] Human Tumor Cells Killed by Anthracyclines Induce a Tumor-Specific Immune Response In this study, scientists investigated the capacity of clinically used chemotherapeutics to induce immunogenic cell death in human tumor cell lines and primary tumor cells. [Cancer Res] Natura-Alpha Targets Forkhead Box M1 and Inhibits Androgen-Dependent and -Independent Prostate Cancer Growth and Invasion Natura-alpha could serve as a novel and effective therapeutic agent for treatment of both hormone sensitive and hormone refractory prostate cancer with minimal side effects [Clin Cancer Res] Berberine Suppresses Androgen Receptor Signaling in Prostate Cancer In this study, researchers investigated the effect of berberine on androgen receptor signaling in prostate cancer. [Mol Cancer Ther] Chemopreventive Effect of PSP through Targeting of Prostate Cancer Stem Cell-Like Population Investigators report that PSP, an active component extracted from the mushroom Turkey tail (Coriolus versicolor), is effective in targeting prostate cancer stem/progenitor cells. [PLoS One] Inhibition of Histone Deacetylase 1 by Maspin Abrogates Epigenetic Silencing of Glutathione S-Transferase Pi (GSTp) in Prostate Carcinoma Cells Researchers report that maspin expression in prostate cancer cell line DU145 reversed GSTp DNA methylation, as measured by methylation-specific PCR, MethyLight assay and bisulfite sequencing. [Mol Cancer Res] CLINICAL RESEARCH Abiraterone and Increased Survival in Metastatic Prostate Cancer Scientists evaluated whether abiraterone acetate prolongs overall survival among patients with metastatic castration-resistant prostate cancer who have received chemotherapy. [N Engl J Med] Genome-Wide Association Study of Prostate Cancer in Men of African Ancestry Identifies a Susceptibility Locus at 17q21 In search of common risk alleles for prostate cancer that could contribute to high rates of the disease in men of African ancestry, investigators conducted a genome-wide association study, with 1,047,986 SNP markers examined in 3,425 African-Americans with prostate cancer (cases) and 3,290 African-American male controls. [Nat Genet] Physical Activity After Diagnosis and Risk of Prostate Cancer Progression: Data from the Cancer of the Prostate Strategic Urologic Research Endeavor Researchers prospectively examined vigorous activity and brisk walking after diagnosis in relation to risk of prostate cancer progression among 1,455 men diagnosed with clinically localized prostate cancer. [Cancer Res] A Large Cohort Study of Long-Term Acetaminophen Use and Prostate Cancer Incidence Investigators examined the association between acetaminophen use and prostate cancer incidence among 78,485 men in the Cancer Prevention Study II Nutrition Cohort. [Cancer Epidemiol Biom Prev] |