TOP STORY Prostate Cancer: Beta Control Your Hormones Researchers describe a signaling pathway involving estrogen receptor beta (ERbeta) that governs whether prostate carcinoma cells maintain an epithelial phenotype or undergo epithelial-mesenchymal transition, suggesting that ERbeta would have prognostic or therapeutic value. [Cancer Cell]
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CURRENT PUBLICATIONS LABORATORY RESEARCH ER(Beta) Impedes Prostate Cancer EMT by Destabilizing HIF-1(Alpha) and Inhibiting VEGF-Mediated Snail Nuclear Localization: Implications for Gleason Grading Researchers report that a key function of ER(beta) and its specific ligand 5(alpha)-androstane-3(beta),17(beta)-diol [3(beta)-adiol] is to maintain an epithelial phenotype and repress mesenchymal characteristics in prostate carcinoma. [Cancer Cell] Immunohistochemical Expression of BRCA1 and Lethal Prostate Cancer Researchers hypothesized that BRCA1 expression in prostate tumor tissue may be associated with prostate cancer progression through regulation of the cell cycle. [Cancer Res] ID1 Enhances Docetaxel Cytotoxicity in Prostate Cancer Cells through Inhibition of p21 To identify potential mechanisms underlying prostate cancer chemotherapy response and resistance, researchers compared the gene expression profiles in high-risk human prostate cancer specimens before and after neoadjuvant chemotherapy and radical prostatectomy. [Cancer Res] Human Carboxypeptidase A4: Characterization of the Substrate Specificity and Implications for a Role in Extracellular Peptide Processing In the present study, researchers determined that carboxypeptidase A4 is secreted from cells as a soluble proenzyme that can be activated by endoproteases such as trypsin. [J Biol Chem] Aberrant Activation of the Androgen Receptor by NF-(Kappa)B2/p52 in Prostate Cancer Cells In the present study, researchers showed that NF-(kappa)B/p52 can activate the androgen receptor (AR), resulting in increased transactivation of AR-responsive genes, such as PSA and NKX3.1, in a ligand-independent manner. [Biochemistry] Usefulness of the Top-Scoring Pairs of Genes for Prediction of Prostate Cancer Progression The top-scoring pair approach can be used to identify patients whose prostate cancer will progress after they undergo radical prostatectomy. Two gene pairs can predict which men would experience progression to the metastatic form of the disease. [Prostate Cancer Prostatic Dis] MicroRNA Let-7a Inhibits Proliferation of Human Prostate Cancer Cells In Vitro and In Vivo by Targeting E2F2 and CCND2 In this study, researchers used in vitro and in vivo approaches to investigate whether E2F2 and CCND2 are direct targets of let-7a, and if let-7a acts as a tumor suppressor in prostate cancer by down-regulating E2F2 and CCND2. [PLoS ONE] CLINICAL RESEARCH Risk of Thromboembolic Diseases in Men with Prostate Cancer: Results from the Population-Based PCBaSe Sweden Researchers investigated the risk of thromboembolic disease in men with prostate cancer who were receiving endocrine treatment, curative treatment, or surveillance. [Lancet Oncol] Antitumour Activity of MDV3100 in Castration-Resistant Prostate Cancer: A Phase I-II Study Because growth of castration-resistant prostate cancer is dependent on continued androgen-receptor signalling, researchers assessed the antitumour activity and safety of MDV3100 in men with this disease. [Lancet]
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POLICY NEWS University of Chicago Physician Named to Presidential Commission for the Study of Bioethical Issues Daniel Sulmasy, MD, PhD, the Kilbride-Clinton Professor of Medicine and Ethics in the Department of Medicine and the Divinity School, and Associate Director of the MacLean Center for Clinical Medical Ethics at the University of Chicago, has been named to the Presidential Commission for the Study of Bioethical Issues. [Presidential Commission for the Study of Bioethical Issues, United States] National Human Genome Research Institute Names New Chief of Genome Technology Branch The National Human Genome Research Institute (NHGRI), part of the National Institutes of Health, has named Lawrence C. Brody, Ph.D., as the new chief of its Genome Technology Branch, the largest of seven branches in the NHGRI Division of Intramural Research. [National Institutes of Health, United States] Minor Use Minor Species Development of Drugs; Research Project Grant (R01) (RFA-FD-10-001) [National Institutes of Health, United States] Bioengineering Nanotechnology Initiative [STTR (R41/R42)] (PA-10-149) [National Institutes of Health, United States] Bioengineering Nanotechnology Initiative [SBIR (R43/R44)] (PA-10-150) [National Institutes of Health, United States] Clinical Investigator Status (Biologics) [Food and Drug Administration, United States] Background on Study Results of U.S. Academic Researchers [Food and Drug Administration, United States] Secretary Sebelius Announces Five New Health and Human Services Regional Directors [Department of Health & Human Services, United States]
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EVENTS American Association for Cancer Research (AACR) 101st Annual Meeting April 17-21, 2010 Washington, DC, United States American Urological Association (AUA) 2010 Annual Meeting May 29-June 3, 2010 San Francisco, United States International Society for Stem Cell Research (ISSCR) 8th Annual Meeting June 16-19, 2010 San Francisco, United States 21st Meeting of the European Association for Cancer Research (EACR) June 26-29, 2010 Oslo, Norway United Kingdom National Stem Cell Network (UKNSCN) Third Annual Scientific Conference July 12-14, 2010 Nottingham, United Kingdom 2010 World Cancer Congress August 18-21, 2010 Shenzhen, China Joint Annual Meeting of the International Continence Society (ICS) and International Urogynecological Association (IUGA) August 23-27, 2010 Toronto, Canada 28th World Congress of Endourology and SWL September 1-4, 2010 Chicago, United States 35th European Society for Medical Oncology (ESMO) Congress October 8-12, 2010 Milan, Italy Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.
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