LABORATORY RESEARCH Bone-Induced c-Kit Expression in Prostate Cancer: A Driver of Intraosseous Tumor Growth Researchers showed that c-kit expression promotes migration and invasion of prostate cancer (PCa) cells. They also found that c-kit expression in PCa cells parallels BRCA2 downregulation. [Int J Cancer] Abstract Effects of Functional Genetic Polymorphisms in the CYP19A1 Gene on Prostate Cancer Risk and Survival Scientists investigated the functions of CYP19A1 polymorphisms and their associations with prostate cancer risk and clinical outcome. The functions of single nucleotide polymorphisms were determined by reporter gene assays in PC3 and DU145 cell lines. [Int J Cancer] Abstract The Combination of the Prodrugs Perforin-CEBPD and Perforin-Granzyme B Efficiently Enhances the Activation of Caspase Signaling and Kills Prostate Cancer Researchers showed that the combination of a perforin (PF)-CCAAT/enhancer binding protein delta (CEBPD) prodrug and a PF-granzyme B prodrug showed an additive effect in triggering the apoptotic pathway and enhancing apoptosis in prostate cancer cells. [Cell Death Dis] Full Article Pigment Epithelium-Derived Factor Expression Prolongs Survival and Enhances the Cytotoxicity of Low-Dose Chemotherapy in Castration-Refractory Prostate Cancer Scientists report the anti-tumor effect of the angio-inhibitory pigment epithelium-derived factor in the metastatic LNCaP-derivative castration-refractory prostate cancer CL1 model and explore PEDF anti-neoplasic efficacy in combination with low-dose chemotherapy. [Cell Death Dis] Full Article COX-2 Inhibitors Arrest Prostate Cancer Cell Cycle Progression by Down-Regulation of Kinetochore/Centromere Proteins Treatment with the COX-2 inhibitors celecoxib and CAY10404 or knockdown of COX-2 significantly inhibited prostate cancer cell proliferation. [Prostate] Abstract NPM1 Silencing Reduces Tumor Growth and MAPK Signaling in Prostate Cancer Cells To better understand nucleophosmin (NPM1) functions in prostate cancer cells, researchers sought to characterize its impact on prostate cancer cells behavior and decipher the mechanisms by which it may act. They showed that NPM1 favors prostate tumor cell migration, invasion and colony forming. [PLoS One] Full Article Distinct Phenotypes of Human Prostate Cancer Cells Associate with Different Adaptation to Hypoxia and Pro-Inflammatory Gene Expression Scientists explored how different features, including differentiation and aggressiveness, of prostate tumor cell lines impact on the hypoxic remodeling of pro-inflammatory gene expression and malignancy. [PLoS One] Full Article AKT and AMPK Activation after High-Fat and High-Glucose In Vitro Treatment of Prostate Epithelial Cells Investigators analyzed the proliferation profile of nonmalignant human prostate epithelial cells after exposure to elevated levels of fat and glucose. [Horm Metab Res] Abstract CLINICAL RESEARCH A Randomized Phase II Study of Cediranib Alone versus Cediranib in Combination with Dasatinib in Docetaxel Resistant, Castration Resistant Prostate Cancer Patients Phase II studies of cediranib and dasatinib in castration-resistant prostate cancer (CRPC) have shown single agent activity. Docetaxel-pretreated CRPC patients were randomized to arm A: cediranib alone versus arm B: cediranib plus dasatinib given orally on four-week cycles. [Invest New Drugs] Abstract The Impact of Multiparametric Pelvic Magnetic Resonance Imaging on Risk Stratification in Patients With Localized Prostate Cancer Scientists determined the impact of multiparametric magnetic resonance imaging of the prostate on established risk stratification criteria in patients with clinically localized adenocarcinoma of the prostate. [Urology] Abstract |