Prostate Cell News Volume 6.02 | Jan 23 2015

Cytotoxicity of Obacunone and Obacunone Glucoside in Human Prostate Cancer Cells Involves Akt-Mediated Programmed Cell Death
Scientists report the mechanism of cytotoxicity of citrus-derived obacunone and obacunone glucoside on human androgen-dependent prostate cancer LNCaP cells. [Toxicology] Abstract

Ginkgetin Inhibits the Growth of DU-145 Prostate Cancer Cells through Inhibition of STAT3 Activity
Ginkgetin inhibited both inducible and constitutively activated signal transducer and activator of transcription 3 (STAT3) and blocked the nuclear translocation of p-STAT3 in DU-145 prostate cancer cells. [Cancer Sci] Abstract

Androgen-Regulation of the Protein Tyrosine Phosphatase PTPRR Activates ERK1/2 Signaling in Prostate Cancer Cells
Characterisation of PTPRR protein in LNCaP cells revealed it is an early and direct target of the androgen receptor which negatively regulates the RAS/ERK1/2 pathway and reduces cell proliferation in response to androgens. [BMC Cancer]
Full Article

Downregulation of EphA5 by Promoter Methylation in Human Prostate Cancer
Researchers investigated the expression and an epigenetic change of EphA5 in prostate cancer and determined if these findings were correlated with clinicopathologic characteristics of prostate cancer. [BMC Cancer] Abstract | Full Article

MAPK and JAK/STAT Pathways Targeted by miR-23a and miR-23b in Prostate Cancer: Computational and In Vitro Approaches
MAPK and JAK/STAT pathways are known to have essential roles in cell proliferation and neoplastic transformation in different cancers including prostate cancer. Scientists aimed to identify microRNAs (miRNAs) that target these pathways in the context of prostate cancer as therapeutic molecules. They then analyzed the expression of candidate miRNAs in LNCAP and PC3 cell lines as well as prostate cancer clinical samples. [Tumor Biol] Abstract

Cycloartan-24-Ene-1α,2α,3β-Triol, a Cycloartane-Type Triterpenoid from the Resinous Exudates of Commiphora myrrha, Induces Apoptosis in Human Prostatic Cancer PC-3 Cells
Researchers isolated a cycloartane triterpenoid from Commiphora myrrha and evaluated its anticancer potential. Cycloartan-24-ene-1α,2α,3β-triol showed cytotoxic activity on PC-3 cells in a concentration-dependent manner with an IC50 value of 9.6 µM at 24 hours. [Oncol Rep] Abstract

Proapoptotic Effect of Endocannabinoids in Prostate Cancer Cells
Researchers aimed to detect the presence of cannabinoid receptors on cancer cells with a prostatic origin and evaluated the effect of the in vitro use of synthetic analogs. [Oncol Rep] Abstract | Download Full Article

Peperotetraphin Inhibits the Proliferation of Human Prostate Cancer Cells via Induction of Cell Cycle Arrest and Apoptosis
Peperotetraphin is a novel cyclobutane-type norlignan, which was isolated from the whole plant of Peperomia tetraphylla. Scientists explored its anti-tumor effect and the molecular mechanism in human prostate cancer PC-3 cell lines. [Med Oncol] Abstract

CLINICAL RESEARCH

Abiraterone Acetate plus Prednisone versus Placebo plus Prednisone in Chemotherapy-Naive Men with Metastatic Castration-Resistant Prostate Cancer (COU-AA-302): Final Overall Survival Analysis of a Randomized, Double-Blind, Placebo-Controlled Phase III Study
The authors present the prespecified final analysis of the COU-AA-302 trial, assessing the effect of abiraterone acetate plus prednisone on overall survival, time to opiate use, and use of other subsequent therapies. [Lancet Oncol] Abstract

Activity of Enzalutamide in Men with Metastatic Castration-Resistant Prostate Cancer Is Affected by Prior Treatment with Abiraterone and/or Docetaxel
Investigators examined the response and outcomes of enzalutamide-treated metastatic castration-resistant prostate cancer patients in the real-world context of prior treatments of abiraterone and/or docetaxel. [Prostate Cancer Prostatic Dis] Abstract

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New Animal Models Faithfully Reproduce the Tumor of Each Patient
A team from the Catalan Institute of Oncology and Bellvitge Biomedical Research Institute has developed new animal models that reproduce faithfully the evolution and malignancy of different human tumors. [Bellvitge Biomedical Research Institute] Press Release

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NEW Postdoctoral Researcher – Prostate Cancer (University of Pennsylvania)

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