LABORATORY RESEARCH Nuclear Receptor Corepressor 1 Expression and Output Declines with Prostate Cancer Progression Researchers investigated the expression of nuclear receptor corepressor 1 (NCOR1) in human prostate and prostate cancer and the role of NCOR1 in response to antiandrogens. [Clin Cancer Res] Abstract | Full Article Specific Delivery of miRNA for High Efficient Inhibition of Prostate Cancer by RNA Nanotechnology The authors report the application of RNA nanotechnology for specific and efficient delivery of anti-miRNA seed-targeting sequence to block the growth of prostate cancer in mouse models. [Mol Ther] Abstract Long Non-Coding RNAs Harboring miRNA Seed Regions Are Enriched in Prostate Cancer Exosomes Scientists characterized the expression of long non-coding RNAs (lncRNAs) in several prostate cancer exosomes and their parental cell lines. They showed that certain lncRNAs are enriched in cancer exosomes with the overall expression signatures varying across cell lines. [Sci Rep] Full Article Detection of DNA Viruses in Prostate Cancer Researchers tested prostatic secretions from men with and without prostate cancer (13 cases and 13 matched controls) or prostatitis (18 cases and 18 matched controls) with metagenomic sequencing. [Sci Rep] Full Article Expression of Two WFDC1/ps20 Isoforms in Prostate Stromal Cells Induces Paracrine Apoptosis through Regulation of PTGS2/COX-2 Prostrate stromal 20 expression enhanced the proliferation of LNCaP cells, whereas stromal WPMY-1 cells were inhibited and underwent increased apoptosis. Prostrate stromal 20-expressing WPMY-1 cells secrete a potently proapoptotic conditioned media. [Br J Cancer] Abstract Mitochondrial Dysfunction-Mediated Apoptosis Resistance Associates with Defective Heat Shock Protein Response in African-American Men with Prostate Cancer Glycolytic pathway inhibitor dichloroacetate inhibited cell proliferation in both African–American (AA) prostate cancer (PCa) cells and Caucasian American (CA) PCa cells. AA cells possess reduced endogenous reactive oxygen species, mitochondrial membrane potential, and mitochondrial mass compared with CA cells. [Br J Cancer] Abstract Tbx18 Regulates the Differentiation of Periductal Smooth Muscle Stroma and the Maintenance of Epithelial Integrity in the Prostate The authors demonstrated for the first time that T-box transcription factor Tbx18 is required for the normal development of periductal smooth muscle stromal cells in prostate, particularly in the anterior lobe, with a clear impact on prostate health in adult mice. [PLoS One] Full Article CLINICAL RESEARCH Radium-223 Outcomes after Multiple Lines of Metastatic Castration-Resistant Prostate Cancer Therapy in Clinical Practice: Implication of Pre-Treatment Spinal Epidural Disease Researchers investigated the impact of baseline spinal epidural disease on metastatic castration-resistant prostate cancer patients treated with radium-223. [Prostate Cancer Prostatic Dis] Abstract |