Prostate Cell News Volume 7.24 | Jul 08 2016

TOP STORY

Men with Metastatic Prostate Cancer Should Be Considered for Germline Genetic Testing of DNA Repair Genes

Researchers showed an association between advanced prostate cancer and mutations in DNA repair genes and observed that these mutations are significantly more frequent in advanced as opposed to localized disease (11.8 percent versus 4.6 percent). [Press release from Memorial Sloan Kettering Cancer Center discussing online prepublication in New England Journal of Medicine] Press Release | Full Article

(Ranked by impact factor of the journal)

LABORATORY RESEARCH

Jagged1 Upregulation in Prostate Epithelial Cells Promotes Formation of Reactive Stroma in the Pten Null Mouse Model for Prostate Cancer

Jagged1 overexpression did not significantly accelerate prostate cancer initiation and progression in the context of loss-of-function of Pten, but alters tumor histopathology and microenvironment. [Oncogene] Abstract

Overexpression of AKR1C3 Significantly Enhances Human Prostate Cancer Cells Resistance to Radiation

Researchers found that overexpression of Aldo-keto reductase 1C3 (AKR1C3) significantly enhanced human prostate cancer cells resistance to radiation through activation of MAPK pathway. [Oncotarget] Abstract

Dual Tumor Suppressing and Promoting Function of Notch1 Signaling in Human Prostate Cancer

Investigators reconciled conflicting data on the role of Notch1 in prostate cancer. [Oncotarget] Abstract

TMPRSS4 Induces Invasion and Proliferation of Prostate Cancer Cells through Induction of Slug and Cyclin D1

Scientists explored TMPRSS4-mediated cellular functions and the underlying mechanisms. TMPRSS4 induced Slug, an epithelial-mesenchymal transition-inducing transcription factor, and cyclin D1 through activation of activating protein-1, composed of c-Jun and activating transcription factor-2, which resulted in enhanced invasion and proliferation of PC3 prostate cancer cells. [Oncotarget] Full Article

Role of Protein S in Castration-Resistant Prostate Cancer-Like Cells

Investigators reported for the first time the upregulation of Protein S (PROS), an anticoagulant plasma glycoprotein with multiple biologic functions, in androgen-insensitive advanced prostate cancer (PCa) cells and in experimentally induced castration-resistant PCa cells. [Endocr Relat Cancer] Abstract

Protein Kinase A Can Block EphA2 Receptor-Mediated Cell Repulsion by Increasing EphA2 S897 Phosphorylation

Researchers identified small molecules counteracting EphA2 canonical signaling, they developed a high-content screening platform measuring inhibition of ephrin-A1-induced PC3 prostate cancer cell retraction. [Mol Biol Cell] Full Article

Reversible Lysine-Specific Demethylase 1 Antagonist HCI-2509 Inhibits Growth and Decreases C-MYC in Castration- and Docetaxel-Resistant Prostate Cancer Cells

Researchers examined the antitumor efficacy of Lysine-Specific Demethylase 1 inhibition with HCI-2509 in advanced stages of prostate cancer. [Prostate Cancer Prostatic Dis] Full Article

Influence of Matrices on 3D-Cultured Prostate Cancer Cells’ Drug Response and Expression of Drug-Action Associated Proteins

Scientists investigated the effects of matrix on the behaviors of 3D-cultured cells of two prostate cancer cell lines, LNCaP and DU145. [PLoS One] Full Article

Aberrant Lipid Metabolism Promotes Prostate Cancer: Role in Cell Survival under Hypoxia and Extracellular Vesicles Biogenesis

Recent studies have focused on the identification of novel metabolic characteristics of Prostate cancer (PCa), aimed at devising better preventive and therapeutic approaches. PCa cells have revealed unique metabolic features such as higher expression of several enzymes associated with de novo lipogenesis, fatty acid up-take and β-oxidation. This aberrant lipid metabolism has been reported to be important for PCa growth, hormone-refractory progression and treatment resistance. [Int. J. Mol. Sci.] Full Article | Graphical Abstract

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Robotic Rectum May Aid Prostate Cancer Diagnosis

A robotic rectum may help doctors and nurses detect prostate cancer. The technology, which was presented at the Eurohaptics conference, is now being adapted for gynaecological exams. [Press release from Imperial College London discussing research presented at Eurohaptics, London, UK] Press Release

NICE backs Ferring’s Firmagon

Men with advanced hormone-dependent prostate cancer and spinal metastases are to gain routine access to Ferring’s Firmagon on the NHS after a u-turn by the National Institute for Health and Care Excellence (NICE) saw the cost regulator issue final draft guidance endorsing its use. [PharmaTimes Media Limited] Press Release

GenomeDx Biosciences Receives Accreditation from College of American Pathologists

GenomeDx Biosciences announced that it has received Laboratory Accreditation from the College of American Pathologists (CAP) based on results of a recent on-site inspection as part of the CAP Laboratory Accreditation Program. [GenomeDx] Press Release

A Simple Proposal for the Publication of Journal Citation Distributions

Although the Journal Impact Factor (JIF) is widely acknowledged to be a poor indicator of the quality of individual papers, it is used routinely to evaluate research and researchers. Scientists present a simple method for generating the citation distributions that underlie JIFs. [bioRxiv] Editorial

Wellcome Trust Launches Open-Access Publishing Venture

One of the world’s largest biomedical charities, the Wellcome Trust in London, will launch an open-access publishing venture later this year. The idea behind Wellcome Open Research is to allow Wellcome grant recipients to publish their findings more quickly and to create a model that, according to the charity, other funders might adopt in future. [Nature News] Editorial

NEW 2016 National Cancer Research Institute (NCRI) Cancer Conference
November 6-9, 2016
Liverpool, United Kingdom

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NEW PostDoctoral Fellow – Prostate Cancer (Baylor College of Medicine (BCM))

NEW Clinical Laboratory Scientist (GenomeDx)

NEW Associate Editor (PLOS ONE)

Faculty Positions – Cancer Immunology (University of New Mexico Health Science Center)

Postdoctoral Position – Molecular Biology/Prostate Cancer (FIBICO)

Postdoctoral Associate – Cancer Research (Sanford Burnham Prebys Medical Discovery Institute)

Postdoctoral Scientist – Cancer Biology (Medical Research Council)

Research Technologist – Mammary and Prostate Stem Cell Biology (STEMCELL Technologies Inc.)

Postdoctoral Fellow – Cancer Research (University of California – San Francisco)

Postdoctoral Fellow – Signaling and Epigenetic Regulation (Medical University of South Carolina)

Postdoctoral Fellow – Prostate Cancer and Metabolism (Cleveland Clinic)

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