Prostate Cell News 8.21 June 9, 2017 | |
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TOP STORY‘Once in a Career Feeling’ as Trial Shows Offering Prostate Cancer Drug Earlier Improves Survival According to results from the Cancer Research UK-funded STAMPEDE clinical trial, offering abiraterone plus prednisolone in combination with standard therapy to men with prostate cancer earlier, before the disease becomes resistant to standard hormone therapy, can help boost survival. [Press release from the Cancer Research UK discussing online prepublication in The New England Journal of Medicine] Press Release | Full Article | Press Release 2 | |
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PUBLICATIONS(Ranked by impact factor of the journal)LABORATORY RESEARCHWidespread genome hypo-methylation and promoter hyper-methylation of epithelium-specific genes are hallmarks of stable epithelial-to-mesenchymal transition (EMT), which in prostate cancer (PCa) correlates with castration resistance, cancer stem cells generation, chemoresistance and worst prognosis. Exploiting their consolidated ex-vivo system, scientists showed that cancer-associated fibroblasts released factors had pivotal roles in inducing genome methylation changes required for EMT and stemness in EMT-prone PCa cells. [Oncogene] Abstract Androgen Receptor Deregulation Drives Bromodomain-Mediated Chromatin Alterations in Prostate Cancer Histone acetylation readers such as bromodomain-containing protein 4 have been shown to associate with transcription factors and contribute to aggressive cancers including prostate cancer. Researchers showed that chromatin accessibility defines castration-resistant prostate cancer. They showed that the deregulation of androgen receptor (AR) expression is a driver of chromatin relaxation and that AR/androgen-regulated bromodomain-containing proteins mediate this effect. [Cell Rep] Full Article | Graphical Abstract Scientists developed hybrid molecules named specific and non-genetic inhibitor of IAP-dependent protein erasers (SNIPERs) that recruit IAP ubiquitin ligases to degrade target proteins. They showed that novel SNIPERs are capable of inducing proteasomal degradation of the androgen receptor. [J Med Chem] Abstract Inhibition of Autophagy Prevents Cadmium-Induced Prostate Carcinogenesis Cadmium, an established carcinogen, is a risk factor for prostate cancer. Researchers investigated the ability of psoralidin, a non-toxic, orally bioavailable compound to inhibit cadmium-induced autophagy to prevent prostate cancer. Psoralidin was studied using cadmium-transformed prostate epithelial cells, which exhibit high proliferative, invasive and colony forming abilities. [Br J Cancer] Abstract The authors investigated the role of androgen receptor (AR) in regulating CXC chemokine receptor 7 (CXCR7). Androgen deprivation or AR inhibition significantly increased CXCR7 expression in androgen-responsive prostate cancer cell lines, which was accompanied by enhanced epidermal growth factor receptor-mediated mitogenic signaling, promoting tumor cell survival through an androgen-independent signaling program. [Sci Rep] Full Article PSMA is a membrane protein that is overexpressed manifold in prostate cancer and provides an attractive target for molecular therapy. Near infrared photoimmunotherapy (NIR-PIT) is a highly selective tumor treatment that employs an antibody-photo-absorber conjugate. Investigators describe the efficacy of NIR-PIT, using a fully human IgG1 anti-PSMA monoclonal antibody, conjugated to the photo-absorber, IR700DX, in a PSMA expressing PC3 prostate cancer cell line. [Mol Cancer Res] Abstract Investigators characterized the expression profile of FALEC in prostate cancer and paired histologically normal tissues. Additionally, biological function of FALEC in prostate cancer (PCa) cell lines was determined by in vitro and in vivo assays. [Prostate] Abstract Whole-Genome Sequence of the Metastatic PC3 and LNCaP Human Prostate Cancer Cell Lines Scientists report short-read whole-genome sequencing and de novo assembly of PC3 and LNCaP. A known homozygous mutation in TP53 and homozygous loss of PTEN were robustly identified in the PC3 cell line, whereas the LNCaP cell line exhibited a larger number of putative inactivating somatic point and indel mutations. [G3 (Bethesda)] Abstract High-throughput screening of a natural compound library was performed to identify the most efficacious combinatorial treatment on prostate cancer. Ursolic acid, curcumin and resveratrol was selected for further analyses and administered in vivo via the diet, either alone or in combination, in a mouse allograft model of prostate cancer. All possible combinations of these natural compounds produced synergistic effects on tumor size and weight, as predicted in the screens. [npj Precis Oncol] Full Article | Press Release CLINICAL RESEARCHAdult Prostatic Sarcoma: A Contemporary Multicenter Rare Cancer Network Study Researchers report results of a large multicentric contemporary cohort of prostatic sarcoma (PS) patients. They included 61 adult PS patients treated in 16 American and European Institutions. Curative surgery was delivered in 48 patients, usually with lymphadenectomy. Curative radiotherapy was delivered in 32 patients, as radical, neoadjuvant, or postoperative treatment. [Prostate] Abstract | |
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REVIEWS27-Hydroxycholesterol: A Novel Player in Molecular Carcinogenesis of Breast and Prostate Cancer The authors highlight recent findings pertaining to the role of 27-hydroxycholesterol in breast cancer and prostate cancer and delineate the signaling mechanisms involved in the governing of different facets of tumor biology. [Chem Phys Lipids] Abstract Visit our reviews page to see a complete list of reviews in the prostate cell research field. | |
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SCIENCE NEWSZenith Announces Issuance of Patent for ZEN-3694 and Presentation Details Zenith Capital Corp. announced that a patent covering its clinical compound, ZEN-3694, has been issued by the United States Patent and Trademark Office. ZEN-3694, a small molecule BET bromodomain inhibitor, is in clinical development for metastatic castrate resistant prostate cancer as a single agent and in combination with enzalutamide. [Press release from Zenith Epigenetics Ltd. discussing research to be presented at BIO International Convention, San Diego] Press Release | |
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INDUSTRY NEWSAstellas Pharma Inc. announced the amendment of the protocol for the registrational PROSPER trial, a multi-national, randomized, double-blind, placebo-controlled study evaluating the efficacy and safety of XTANDI in patients with non-metastatic castration-resistant prostate cancer. [Astellas Pharma Inc.] Press Release Sophiris Bio Inc. announced that the first patient has been dosed in its Phase IIb study to evaluate the safety and tolerability of topsalysin in focally treating men with clinically significant localized prostate cancer. Topsalysin is an innovative, first-in-class pore-forming protein engineered to be activated only in the presence of enzymatically-active PSA, which is only found within the prostate. [Sophiris Bio Inc.] Press Release | |
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POLICY NEWSUK Scientists Hope for Softened Brexit after Shock Election Result The United Kingdom (UK)’s general election produced no clear outcome — but scientists trying to divine meaning from the chaos say they hope the result will ultimately benefit their country’s research ties with the European Union. [Nature News] Editorial New Clues to Why a French Drug Trial Went Horribly Wrong Scientists are one step closer to understanding how a clinical trial in France killed one volunteer and led to the hospitalization of five others. A new study shows that the compound tested in the study, BIA 10-2474, has effects on many other enzymes in addition to the one it was supposed to inhibit. These “off-target” effects might explain why the drug caused side effects ranging from headaches to irreversible brain damage. [ScienceInsider] Editorial
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EVENTSNEW 2017 The National Cancer Research Institute (NCRI) Cancer Conference Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Fellow – Prostate Cancer and Head & Neck Cancer (University of Maryland) Assistant Member – Prostate Cancer (Fred Hutchinson Cancer Research Center) Postdoctoral Fellow – Drug Discovery (The Vancouver Prostate Centre) Research Associate – Prostate Cancer (Meharry Medical College) Postdoctoral Fellow – Mammalian Stem Cell Biology (NYU School of Medicine) Postdoctoral Fellow – Translational Prostate Cancer Research (Weill Cornell Medicine) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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