Prostate Cell News Volume 8.36 | Sep 22 2017

TOP STORY

Mitochondrial Mutations Drive Prostate Cancer Aggression

Researchers sequenced the mitochondrial genomes of 384 localized prostate cancer patients, and identified a median of one mitochondrial single-nucleotide variant (mtSNV) per patient. Some of these mtSNVs occured in recurrent mutational hotspots and associated with aggressive disease. [Nat Commun] Full Article

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LSD1-Mediated Epigenetic Reprogramming Drives CENPE Expression and Prostate Cancer Progression

Scientists report that the chromatin modifier LSD1, an important regulator of androgen receptor transcriptional activity, underwent epigenetic reprogramming in castration-resistant prostate cancer (CRPC). LSD1 reprogramming in this setting activated a subset of cell cycle genes including CENPE, a centromere binding protein and mitotic kinesin. CENPE was regulated by the co-binding of LSD1 and AR to its promoter, which was associated with loss of RB1 in CRPC. [Cancer Res] Abstract

Endogenous Androgen Receptor Proteomic Profiling Reveals Genomic Subcomplex Involved in Prostate Tumorigenesis

The authors applied immunoprecipitation mass spectrometry of endogenous androgen receptor (AR) in LNCaP cells to identify components of the AR transcriptional complex. In total, 66 known and novel AR interactors were identified in the presence of synthetic androgen, most of which were critical for AR-driven prostate cancer cell proliferation. [Oncogene] Abstract

MYC Drives Overexpression of Telomerase RNA (hTR/TERC) in Prostate Cancer

By using three orthogonal methods including RNAseq, RT-qPCR, and an analytically validated chromogenic RNA in situ hybridization assay, scientists report consistent overexpression of TERC in prostate cancer. This overexpression occured at the precursor stage, and persisted throughout all stages of disease progression. [J Pathol] Abstract

Diindolylmethane and Its Halogenated Derivatives Induce Protective Autophagy in Human Prostate Cancer Cells via Induction of the Oncogenic Protein AEG-1 and Activation of AMP-Dependent Kinase (AMPK)

Researchers found that 3,3′-Diindolylmethane (DIM) and ring-DIMs induced autophagy was accompanied by increased autophagic vacuole formation and conversion of LC3BI to LC3BII in LNCaP and C42B human prostate cancer cells. [Cell Signal] Abstract

Raman Spectroscopy for Accurately Characterizing Biomolecular Changes in Androgen-Independent Prostate Cancer Cells

The authors described Raman finger-printing of normal and metastatic hormone-resistant prostate cancer cells including analyses with principal component analysis and linear discrimination. Androgen-resistant prostate cancer cells presented a higher content of phenylalanine, tyrosine, DNA and Amide III in comparison to PNT2 cells, which possessed greater amounts of L-arginine and had a B conformation of DNA. [J Biophotonics] Abstract

Hyperactive mTOR Induces Neuroendocrine Differentiation in Prostate Cancer Cell with Concurrent Up-Regulation of IRF1

Researchers investigated the role of mammalian target of rapamycin (mTOR) in neuroendocrine-differentiated prostate cancer. Scientists utilized a gain-of-function analysis by establishing a human prostate cancer LNCaP stable line that expresses hyperactive mTOR (LNCaP-mTOR). [Prostate] Abstract

Interference of Dibutylphthalate on Human Prostate Cell Viability

Investigators evaluated the effects of dibutylphthalate (DBP) on human prostate adenocarcinoma epithelial cells in order to highlight xenoestrogens influence on human prostate. They compared DBP effects with 17β-estradiol action in order to investigate possible mimetical behavior. [Ecotoxicol Environ Saf] Full Article

Concurrent Treatment with Simvastatin and NF-κB Inhibitor in Human Castration-Resistant Prostate Cancer Cells Exerts Synergistic Anti-Cancer Effects via Control of the NF-κB/LIN28/Let-7 miRNA Signaling Pathway

The authors examined the anti-cancer effects and molecular mechanism of simvastatin in human castration-resistant prostate cancer cells, particularly focused on LIN28B and its target molecule, let-7 microRNA among the various target genes of NF-κB. [PLoS One] Full Article

Circulating Steroid Hormone Variations Throughout Different Stages of Prostate Cancer

Scientists summarize the currently available data on steroid hormones that have been implicated in the various stages of prostate cancer. They address the implications of these findings, highlights important studies in this field and identifies current gaps in literature. [Endocr Relat Cancer] Abstract | Full Article

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BERG Broadens Relationship With the Department of Defense (DoD) Center For Prostate Disease Research with New Predictive Biomarker Test for Prostate Cancer

BERG announced the completion of clinical validation for a new predictive diagnostic test that can improve detection of prostate cancer. The new test can minimize unnecessary biopsies to distinguish men with prostate cancer compared to those with benign prostate hyperplasia. [BERG, LLC (PR Newswire Association LLC)] Press Release

GW Signs $5.3 Million Agreement to Research Plasma-Based Cancer Therapies

George Washington University has signed a $5.3 million corporate research sponsorship agreement with Maryland-based US Patent Innovations, LLC that will fund a new initiative to develop biomedical applications for cold plasma technology in cancer treatment. [George Washington University] Press Release

£2 Million Award for Cancer Researcher

A University of Dundee scientist has been awarded £2 million to explore the role that one of the most fundamental processes in cell biology plays in cancer. Professor Karim Labib will receive the grant from Cancer Research UK to study mechanisms that preserve genome integrity during the final stages of chromosome replication in animal cells. [University of Dundee] Press Release

United Kingdom Sees Dip in European Research Applications after Brexit Vote

The number of researchers applying for Europe-funded Marie Curie fellowships in the United Kingdom has dipped slightly since the country’s vote to leave the European Union, data released to Nature show. But there is no evidence yet of a sharp collapse in interest, which some scientists had feared in the wake of the Brexit referendum. [Nature News] Editorial

A Far-Right Party Is about to Enter the German Parliament. What Does that Mean for Science?

Angela Merkel will likely remain chancellor after the German elections, but the voting will shake up German federal politics in another way. Polls predict that the far-right Alternative for Germany will get close to 10% of the vote, winning seats in the federal legislature, the Bundestag, for the first time. [ScienceInsider] Editorial

HHMI’s Own Brand of Diversity in the Life Sciences

One of Erin O’Shea’s first moves as Howard Hughes Medical Institute (HHMI) president was committing $25 million a year to support postdocs from underrepresented groups. Her hope was that they would eventually change the color—and culture—of their departments as they moved into leadership positions, in addition to serving as role models for the next generation of scientists. [ScienceInsider] Editorial

NEW Keystone Symposia: Bioenergetics and Metabolic Disease
January 21-25, 2018
Keystone, Colorado, United States

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NEW Postdoctoral Position – Cancer Biology and Epigenetics (Duke University)

NEW Postdoctoral Position – Cancer Immunotherapy (University of Sheffield)

Researcher – Cancer Biology (University of Cincinnati)

Postdoctoral Fellow – Prostate Disease Research (The Henry M. Jackson Foundation for the Advancement of Military Medicine)

Postdoctoral Position – Molecular Imaging for Therapy Assessment in Prostate Cancer (Technische Universität München)

Postdoctoral Position – Prostate Cancer (Moffitt Cancer Center)

Postdoctoral Fellowship – Translational Cancer Disparities Research (Duke Cancer Institute)

Postdoctoral Position – Prostate Cancer (Baylor College of Medicine)

Postdoctoral Position – Prostate Related Diseases (Baylor College of Medicine)

Postdoctoral Fellow – Drug Discovery (Vancouver Prostate Centre)

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