Prostate Cell News Volume 10.11 | Mar 29 2019

TOP STORY

FDPS Cooperates with PTEN Loss to Promote Prostate Cancer Progression through Modulation of Small GTPases/AKT Axis

Scientists evaluated farnesyl diphosphate synthase (FDPS) expression and its cancer-associated phenotypes using in vitro and in vivo methods in PTEN-deficient and sufficient human and mouse prostate cancer cells and tumors. [Oncogene] Abstract

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The Putative Tumor Suppressor Protein Latexin Is Secreted by Prostate Luminal Cells and Is Downregulated in Malignancy

Researchers demonstrated that loss of latexin (LXN) was highly expressed in normal prostate luminal cells but downregulated in high Gleason grade cancers. LXN protein was both cytosolic and secreted by prostate cells and expression was directly and potently upregulated by all-trans retinoic acid. [Sci Rep] Full Article

Membrane Insertion and Secretion of the Engrailed-2 (EN2) Transcription Factor by Prostate Cancer Cells May Induce Antiviral Activity in the Stroma

The distribution of engrailed-2 (EN2) protein in cells was evaluated using immunofluorescence with a set of antibodies raised against overlapping epitopes across the protein, and through the use of an EN2-GFP construct. MX2 expression in primary prostate tumors was evaluated using immunohistochemistry. [Sci Rep] Full Article

Expression of tSTAT3, pSTAT3⁷²⁷, and pSTAT3⁷⁰⁵ in the Epithelial Cells of Hormone‐Naïve Prostate Cancer

The expression of total signal transducer and activator of transcription 3 (tSTAT3), phosphorylated STAT3 (pSTAT3)⁷²⁷, and pSTAT3⁷⁰⁵ was scored in the nuclei and cytoplasm of prostatic gland epithelial cells in two tissue microarrays of paraffin‐embedded prostatic tissue. [Prostate] Full Article

Nimotuzumab Inhibits Epithelial-Mesenchymal Transition in Prostate Cancer by Targeting the Akt/YB‐1/AR Axis

Scientists used both LNCaP, and PC3 and PC3‐androgen receptor cells as a model system and assessed the effects of nimotuzumab on epithelial-mesenchymal transition (EMT) in vitro and in vivo. The EMT makers were detected by immunohistochemistry, qRT‐PCR and Western blot. MTT, wound healing assay, and transwell assay were used to measure cell viability, migration, and invasion, respectively. [IUBMB Life] Abstract

Combination of Cabazitaxel and p53 Gene Therapy Abolishes Prostate Carcinoma Tumor Growth

Investigators developed the AdRGD-PGp53 vector which offered autoregulated expression of p53, resulting in enhanced tumor cell killing in vitro and in vivo. They combined AdRGD-PGp53 along with the chemotherapy drugs used in the clinical treatment of prostate carcinoma, mitoxantrone, docetaxel, or cabazitaxel. [Gene Ther] Abstract

KDM5C Is Transcriptionally Regulated by BRD4 and Promotes Castration-Resistance Prostate Cancer Cell Proliferation by Repressing PTEN

Researchers reported that lysine-specific histone demethylase 5C (KDM5C) was highly expressed in prostate cancer and castration-resistance prostate cancer (CRPC) specimens, and the high expression promoted CRPC cell proliferation through repressing phosphatase and tensin homolog (PTEN) gene epigenetically. [Biomed Pharmacother] Full Article | Graphical Abstract

Raloxifene Decreases Cell Viability and Migratory Potential in Prostate Cancer Cells (LNCaP) with GPR30/GPER1 Involvement

Investigators evaluated raloxifene effects on LNCaP prostate tumor cells modulating the activity of GPER1/GPR30 receptors. [J Pharm Pharmacol] Abstract

Tumor-Derived Extracellular Vesicles Require β1 Integrins to Promote Anchorage-Independent Growth

Using a cell line-based genetic rescue and an in vivo prostate cancer (PrCa) model, researchers showed that gradient purified small extracellular vesicles from either cancer cells or blood from tumor-bearing TRAMP mice promoted anchorage-independent growth of PrCa cells. [iScience] Abstract | Graphical Abstract | Full Article

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Emerging Therapeutic Targets for Patients with Advanced Prostate Cancer

The authors discuss novel targets and agents, studied preclinically and now being validated in clinical trials, including poly ADP-ribose polymerase, enhancer of zeste homologue 2, hedgehog pathway, MDM2/p53, and tyrosine kinase inhibitors. [Cancer Treat Rev] Abstract

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US Department of Veterans Affairs and McGuire Research Institute Join Anixa Biosciences Cchek™ Prostate Cancer Study

Anixa Biosciences, Inc. announced that the Hunter Holmes McGuire VA Medical Center located in Richmond, VA has joined its ongoing prostate cancer Cchek™ study. [Anixa Biosciences, Inc.] Press Release

Arvinas Announces Initiation of Patient Dosing in the First Phase I Clinical Trial of PROTAC™ Protein Degrader, ARV-110

Arvinas, Inc. announced the initiation of patient dosing in its Phase I clinical trial of ARV-110, the company’s oral androgen receptor (AR)-targeted PROTAC™ protein degrader. [Arvinas, Inc.] Press Release

BioXcel Therapeutics Files Clinical Trial Application for the Development of BXCL701 and Pembrolizumab in Neuroendocrine Prostate Cancer (tNEPC)

BioXcel Therapeutics, Inc. announced that it has filed a Clinical Trial Application with the UK health authorities for its lead immuno-oncology asset, BXCL701, an orally-available small molecule immune-modulator with dual mechanisms of action, in combination with pembrolizumab, a checkpoint inhibitor, in tNEPC. [BioXcel Therapeutics, Inc.] Press Release

ESSA Pharma Announces Nomination of EPI-7386 as Lead Clinical Candidate in Metastatic Castration-Resistant Prostate Cancer

ESSA Pharma Inc. announced the nomination of EPI-7386 as the lead clinical candidate for the treatment of metastatic castration-resistant prostate cancer. [ESSA Pharma Inc.] Press Release

University Fights Restrictive Indiana Law on Fetal Tissue Research

A three-judge panel of the Seventh U.S. Circuit Court of Appeals overturned a lower court decision that an Indiana law criminalizing much fetal tissue research is unconstitutionally vague. The ruling moves such work closer to being a felony in the Hoosier State. It’s the most significant court decision yet on laws recently passed in at least seven states that restrict research on tissue from elective abortions. [ScienceInsider] Editorial

NIH May Bar Peer Reviewers Accused of Sexual Harassment

The National Institutes of Health (NIH) in Bethesda, Maryland, reminded the research community this week that the agency can—and sometimes does—bar scientists accused of sexual harassment from serving as peer reviewers. [ScienceInsider] Editorial

NEW Advanced Prostate Cancer Consensus Conference (APCCC) 2019
August 29-31, 2019
Basel, Switzerland

Visit our events page to see a complete list of events in the community.

NEW Research Investigator – Genitourinary Medical Oncology (MD Anderson Cancer Center)

Postdoctoral Fellow and PhD Student Position – Hormone Driven Cancer (Institute of Oncology Research)

Postdoctoral Position – Prostate Cancer (UT Health San Antonio)

Postdoctoral Position – Microenvironment & Cancer (Brigham and Women’s Hospital)

Faculty Position – Prostate Cancer Biology and Cancer Epigenetics (Northwestern University Feinberg School of Medicine)

Research Assistant II – Cancer Biology (MD Anderson Cancer Center)

Senior Computational Biologist – Molecular Oncology (Cancer Research UK Manchester Institute)

Postdoctoral Positions – Stem Cell and Cancer Biology (Columbia University Irving Medical Center)

Postdoctoral Fellow – Cancer Biology (Thomas Jefferson University)

Assistant Professor – Translational Cancer Research (Texas Tech University Health Sciences Center El Paso)

Postdoctoral Position – Prostate Cancer (University of Trento)

Postdoctoral Fellow – Prostate Cancer & Stem Cell Biology (City of Hope)

Postdoctoral Fellow – Cancer Immunotherapy (University of Notre Dame)

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