| TOP STORY | Reprogramming Cells to Fight Diabetes Researchers discovered that many genes in alpha cells are marked by both activating- and repressing-histone modifications. This included many genes important in beta-cell function. In one state, when a certain gene is turned off, the gene can be readily activated by removing a modification that represses the histone. [Press release from the Perelman School of Medicine, University of Pennsylvania discussing the online prepublications in Journal of Clinical Investigation] Press Release | Full Article |
| REVIEWS | New Horizons in Cellular Regulation by Inositol Polyphosphates: Insights from the Pancreatic β-Cell Using the β-cell as their prime but not exclusive example, the authors examine the inositol polyphosphates in three main groups: 1) inositol 1,4,5-trisphosphate and its influence on Ca2+ signaling, specifically in a cell in which cytoplasmic-free Ca2+ concentration is principally increased by plasma membrane standing voltage-gated Ca2+ channels; 2) higher inositol polyphosphates including a novel second messenger inositol 3,4,5,6-tetrakisphosphate and a regulatory role for inositol hexakisphosphate in β-cell Ca2+ homeostasis and exo- and endocytosis; and 3) inositol pyrophosphates and their role in β-cell exocytosis, together with the exciting possibility of being novel targets for therapy in diabetes. [Pharmacol Rev] Abstract Anti-Diabetic Medications and Risk of Pancreatic Cancer in Patients with Diabetes Mellitus: A Systematic Review and Meta-Analysis The authors performed a systematic review and meta-analysis evaluating the effect of metformin, sulfonylureas, thiazolidinediones, and insulin on the risk of pancreatic cancer in patients with diabetes mellitus. [Am J Gastroenterol] Abstract |
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