| PUBLICATIONS (Ranked by impact factor of the journal) | DIABETES Fetal PGC-1α Overexpression Programs Adult Pancreatic β-Cell Dysfunction Scientists showed that glucocorticoids (GCs) stimulate the expression of peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α), a coregulator of the GCs receptor, and that the overexpression of PGC-1α represses genes important for β-cell development and function. [Diabetes] Abstract G6PC2, A Negative Regulator of Basal Glucose-Stimulated Insulin Secretion G6PC2 encodes an islet-specific, endoplasmic reticulum-resident glucose-6-phosphatase catalytic subunit. A combination of in situ perfused pancreas, in vitro isolated islet, and in vivo analyses were used to explore the function of G6pc2 in mice. [Diabetes] Abstract Hydrogen Sulfide-Induced Inhibition of L-Type Ca2+ Channels and Insulin Secretion in Mouse Pancreatic Beta Cells The whole-cell patch-clamp technique was used to record L-type voltage-dependent Ca2+ channels in beta cells from cystathionine γ-lyase-knockout and wild-type mice. Insulin secretion from pancreatic islets and endogenous H2S production in pancreas were measured. [Diabetologia] Abstract Selective Serotonin Reuptake Inhibitors (SSRIs) Inhibit Insulin Secretion and Action in Pancreatic Beta Cells Investigators demonstrated that incubation of murine islets or Min6 β cell line with the SSRIs paroxetine, fluoxetine or sertraline inhibited insulin-induced Tyr phosphorylation of insulin receptor substrate-2 protein and the activation of its downstream targets Akt and S6K1. [J Biol Chem] Abstract | Full Article Galectin-3 Deficiency Protects Pancreatic Islet Cells from Cytokine-Triggered Apoptosis In Vitro The authors aimed to examine whether beta cell apoptosis depends on the presence of galectin-3 and to delineate the underlying mechanism. [J Cell Physiol] Abstract PANCREATIC CANCER Interaction of the Sympathetic Nerve with Pancreatic Cancer Cells Promotes Perineural Invasion through the Activation of STAT3 Signaling Scientists used mouse dorsal root ganglia and pancreatic cancer cells co-cultured in vitro, cellular and molecular biology and animal models to evaluate the function of the sympathetic neurotransmitter norepinephrine in perineural invasion progression and pathogenesis. [Mol Cancer Ther] Abstract Targeted Degradation of KRAS by an Engineered Ubiquitin Ligase Suppresses Pancreatic Cancer Cell Growth In Vitro and In Vivo Interactions between RC-U, an engineered E3 ubiquitin ligase, and KRAS as well as whether RC-U could ubiquitinate KRAS were investigated. Extracellular signal-regulated protein kinase 1/2 (ERK1/2) and phosphorylated ERK 1/2 levels were examined in pancreatic cancer cells transfected with plasmid RC-U. [Mol Cancer Ther] Abstract Downregulation of TRAF2 Mediates NIK-Induced Pancreatic Cancer Cell Proliferation and Tumorigenicity Researchers identified proteasomal downregulation of TNF receptor-associated factor 2 (TRAF2) as a mechanism by which levels of active NF-κB-inducing kinase (NIK) are increased in pancreatic ductal adenocarcinoma cell lines. [PLoS One] Full Article | Press Release MUC5AC Protects Pancreatic Cancer Cells from TNF-Related Apoptosis-Inducing Ligand-Induced Death Pathways The authors previously reported that a specific siRNA transfected MUC5AC could knockdown MUC5AC expression and suppress in vivo tumor growth and metastasis, although it had no effects on in vitro cell growth, cell survival, proliferation and morphology. Here, they investigated which host immune cells induced these effects and how the effects were induced using immunocyte-depleted animal models. [Int J Oncol] Abstract EZH2 Is Required for Breast and Pancreatic Cancer Stem Cell Maintenance and Can Be Used as a Functional Cancer Stem Cell Reporter Researchers hypothesized that epigenetic modification by EZH2 helps maintain the cancer stem cell (CSC) phenotype and that in turn this epigenetic modifier can be used as a reporter for CSC activity in an in vitro high-throughput screening assay. CSCs isolated from pancreatic and breast cancer lines had elevated EZH2 levels over non-CSCs. [Stem Cells Transl Med] Abstract |
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