Sustained Expression of the Transcription Factor GLIS3 Is Required for Normal Beta Cell Function in Adults To determine if sustained Glis3 expression is essential to normal beta cell function, scientists generated Glis3fl/fl/Pdx1CreERT+ animals by intercrossing Glis3fl/fl mice with Pdx1CreERT+ mice and used tamoxifen (TAM) to induce Glis3 deletion in adults. TAM-mediated beta cell-specific inactivation of Glis3 in adult mice downregulates insulin expression, leading to hyperglycemia and subsequently enhanced beta cell apoptosis. [EMBO Mol Med] Full Article
Ectopic Expression of the Heterotrimeric G15 Protein in Pancreatic Carcinoma and Its Potential in Cancer Signal Transduction Based on the fact that PKD1 is a multifunctional protein kinase activated by PKC and known for promoting oncogenic signaling, scientists hypothesized that, if expressed out of its natural cell context, G15 might promote tumor growth. A screening for G15 a-subunit mRNA expression pointed to pancreatic carcinoma among different human cancer cell types and revealed significant expression in human tumor biopsies xenografted in mice. [Cell Signal] Abstract
University of Chicago’s Graeme Bell Receives International Diabetes Prize Graeme Ian Bell, PhD, the Louis Block Distinguished Service Professor of Medicine and Human Genetics and an investigator in the Kovler Diabetes Center at the University of Chicago, has been awarded the Manpei Suzuki International Prize for 2012 for his pioneering work in understanding the role of genetics in the diagnosis and treatment of diabetes. [The University of Chicago Medical Center] Press Release
Myriad Announces Diabetes Collaboration with Sanofi Myriad Genetics announced that Myriad RBM has entered into a research collaboration with Sanofi and Population Health Research Institute at Hamilton Health Sciences and McMaster University. Through this collaboration, Myriad RBM will perform protein biomarker research for the Outcome Reduction with Initial Glargine Intervention study, the world’s longest and largest randomized clinical trial in pre- and early diabetes. [Myriad Genetics, Inc.] Press Release
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