DIABETES A Nuclear-Receptor-Dependent Phosphatidylcholine Pathway with Antidiabetic Effects Scientists show that an unusual phosphatidylcholine species with two saturated 12 carbon fatty acid acyl side chains (dilauroyl phosphatidylcholine) is an LRH-1 agonist ligand in vitro. [Nature] Islet Amyloid Polypeptide Demonstrates a Persistent Capacity to Disrupt Membrane Integrity Researchers investigate islet amyloid polypeptide, which is implicated in the loss of insulin-secreting cells in type II diabetics. [Proc Natl Acad Sci U S A] Transcriptional Profiling of Diabetic Neuropathy in the BKS db/db Mouse: A Model of Type 2 Diabetes Investigators examined changes in global gene expression to define pathways regulated by diabetes in peripheral nerve. [Diabetes] An Islet Endothelial Cell Signal of Importance for β-Cell Function This study tested the hypothesis that endothelial-derived thrombospondin-1 is important for β-cell function. [Diabetes] Activation of Peroxisome Proliferator-Activated Receptor-β/-δ Ameliorates Insulin Signaling and Reduces SOCS3 Levels by Inhibiting STAT3 in Interleukin-6–Stimulated Adipocytes Scientists evaluated whether peroxisome proliferator-activated receptor-β/-δ prevented activation of the interleukin-6-STAT3-suppressor of cytokine signaling 3 (SOCS3) pathway and insulin resistance in adipocytes. [Diabetes] PANCREATIC CANCER VEGF and c-Met Blockade Amplify Angiogenesis Inhibition in Pancreatic Islet Cancer This study compared the cellular effects of XL880 and XL184 to those of an receptor tyrosine kinases inhibitor (XL999) that blocks vascular endothelial growth factor receptor (VEGF) but not c-Met. [Cancer Res] Pancreatic Stellate Cells Radioprotect Pancreatic Cancer Cells through β1-Integrin Signaling Investigators show that pancreatic stellate cells promote radioprotection and stimulate proliferation in pancreatic cancer cells in direct coculture. [Cancer Res] Overexpression of GalNAc-Transferase GalNAc-T3 Promotes Pancreatic Cancer Cell Growth Researchers have found that one of the GalNAc-T enzymes, GalNAc-T3, is overexpressed in human pancreatic cancer tissues and suppression of GalNAc-T3 significantly attenuates the growth of pancreatic cancer cells in vitro and in vivo. [Oncogene] Genome-Wide Analysis of Promoter Methylation Associated with Gene Expression Profiles of Pancreatic Adenocarcinomas The goal of this study was to comprehensively identify CpG island methylation alterations between pancreatic cancers and normal pancreata and their associated gene expression alterations. [Clin Cancer Res] UA62784 Is a Cytotoxic Inhibitor of Microtubules, not CENP-E A recent screen for compounds that selectively targeted pancreatic cancer cells isolated UA62784. Investigators found that UA62784 inhibits microtubule polymerization in vitro. [Chem Biol] Calmodulin Mediates FAS-Induced FADD (Fas Associated Protein with Death Domain)-Independent Survival Signaling in Pancreatic Cancer Cells Via Activation of Src-ERK To understand the resistance of pancreatic tumors to Fas death receptor-induced apoptosis, scientists investigated the molecular mechanisms of Fas-activated survival signaling in pancreatic cancer cells. [J Biol Chem] Clinical Significance of Serum Levels of Immune-Associated Molecules, Uric Acid, Soluble MHC Class I Chain-Related Molecules A and B as Diagnostic Tumor Markers for Pancreatic Ductal Adenocarcinoma The aims of this study were to determine the diagnostic utility of uric acid, soluble MHC class I chain-related molecules A and B in pancreatic ductal adenocarcinoma (PDAC) compared with those of CA19-9, most commonly available tumor markers for PDAC. [Cancer Sci] |