Muscle Cell News 1.12 June 6, 2016 | |
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TOP STORYArtificial Muscle Fibers Help Keep Muscle Stem Cells Potent in Lab Researchers have come up with a way to create a home away from home for the stem cells in the form of artificial muscle fibers. They’ve also identified the particular “soup” of molecules and nutrients necessary to keep the cells in their most potent, regenerative state. [Press release from Stanford Medicine discussing online prepublication in Nature Biotechnology] Press Release | Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)CARDIAC MUSCLE CELLSScientists hypothesized that mesenchymal stem cells can suppress cardiac alternans, an important arrhythmia substrate, by paracrine action on calcium cycling. [J Mol Cell Cardiol] Abstract Researchers identified specific markers of mineralocorticoid receptor (MR) signaling in isolated tissue macrophages (cardiac, aortic) versus splenic mononuclear cells from wild-type and myeloid MR-null mice given vehicle/salt or DOC/salt for eight weeks. [Endocrinology] Abstract Engineered Cardiac Micromodules for the In Vitro Fabrication of 3D Endogenous Macro-Tissues Researchers engineered a new class of cardiac tissue precursor, specifically conceived in order to promote the synthesis and the assembly of a cardiac extracellular matrix. [Biofabrication] Abstract Investigators established Sca-1+/CD31– human telomerase reverse transcriptase-immortalized cardiac stem cells, evaluated their stem cell properties, and paracrine potential in cardiomyocyte survival during hypoxia-induced injury. [Int J Mol Sci] Full Article SKELETAL MUSCLE CELLSWhether gene repositioning to the nuclear periphery during differentiation adds another layer of regulation to gene expression remains controversial. Researchers resolved this by manipulating gene positions through targeting the nuclear envelope transmembrane proteins that direct their normal repositioning during myogenesis. [Mol Cell] Full Article | Graphical Abstract | Press Release Investigators developed a proteomics method to discover dystrophy-associated changes in the muscle progenitor cell niche, which identified serine proteases, and especially neutrophil elastase, as candidates. [Sci Rep] Full Article | Press Release To expand their previous studies collected in a clinically relevant Duchenne muscular dystrophy animal model, the authors investigated the skeletal muscle proteome four months after systemic delivery of allogenic MuStem cells. [Proteomics] Abstract Researchers generated CreLacZ mice in which more than 99.9% of the cardiomyocytes in the left ventricular field were positive for 5-bromo-4-chloro-3-indolyl-β-d-galactoside staining immediately after tamoxifen injection. [PLoS One] Full Article SMOOTH MUSCLE CELLSInvestigators hypothesized that vascular smooth muscle prostaglandin E2 E-Prostanoid 4 receptor deletion predisposes to renal injury via unchecked vasoconstrictive actions of angiotensin II in a hypertension model. [Antioxid Redox Signal] Abstract In urinary bladder smooth muscle, large-conductance calcium-activated potassium channel (BKCa) channel activity underlies the maintenance of the resting membrane potential and the repolarization of the spontaneous action potential triggering the phasic contraction. To identify novel BKCa channel activators, scientists screened a library of natural compounds using a cell-based fluorescence assay and a hyperactive mutant BKCa channel. [Mol Pharmacol] Abstract | |
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REVIEWSThe authors review current methods for determining biophysical parameters of pluripotent stem cell-derived cardiomyocytes that recapitulate disease and drug responses. [Stem Cells] Abstract Visit our reviews page to see a complete list of reviews in the muscle cell research field.
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INDUSTRY NEWSBioMarin Pharmaceutical Inc. announced that it has withdrawn its Kyndrisa™ (drisapersen) Marketing Authorization Application from the European Medicines Agency following discussions at the May 2016 Committee for Medicinal Products for Human Use meeting. [BioMarin Pharmaceutical Inc.] Press Release Morristown Medical Center Commences First-in-Kind Cardiology Program for Athletes The Gagnon Cardiovascular Institute at Morristown Medical Center has commenced a first-in-kind cardiology program for all athletes—whether they be professionals, collegiate, high school, or older competitors, and “weekend warrior” recreational athletes. [Morristown Medical Center (PR Web)] Press Release | |
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EVENTSNEW Gordon Research Conference – Muscle & Molecular Motors Visit our events page to see a complete list of events in the muscle cell community.
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JOB OPPORTUNITIESNEW Associate Professor/Professor – Cardiovascular Research (Monash University) Research Technologist – Myogenic and Progenitor Cell (STEMCELL Technologies Inc.) Postdoctoral Fellow – Regeneration of the Mammalian Heart (UT Southwestern Medical Center) Postdoctoral Fellow – Skeletal Muscle Repair and Performance (GlaxoSmithKline) Postdoctoral Scientist – Airway Smooth Muscle Biology (UCSF) Postdoctoral Fellow – Genome Editing for Striated Muscle Regeneration (Duke University) Postdoctoral Position – Chemical and Structural Biology of RNA (The Scripps Research Institute) PhD Position – Muscle Fiber Type Switch in Congenital Myopathies (King’s College London) Postdoctoral Fellow – Pathogenesis of Heart and Vascular Injury (University of Alberta) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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Home Muscle Cell News Volume 1.12 | Jun 6 2016