Muscle Cell News 1.21 August 15, 2016 | |
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TOP STORYHelper Molecule Reverses Degeneration of Muscle in Mouse Model of Tissue Aging, Wasting Investigators generated mice in which they could restrict the amount of NAD in specific tissues in order to simulate this aspect of normal aging in otherwise healthy mice. Young knockout mice were found to tolerate an 85 percent decline in intramuscular NAD content without losing spontaneous activity or treadmill endurance. [Press release from the University of Pennsylvania discussing online prepublication in Cell Metabolism] Press Release | Abstract | Graphical Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)CARDIAC MUSCLE CELLSResearchers presented a novel, simplified method, demonstrating concomitant isolation of viable cardiac myocytes and non-myocytes from the same adult mouse heart. [Circ Res] Abstract Scientists used a mesoderm posterior 1-Cre/Rosa26-EYFP reporter system to identify microRNAs enriched in early cardiac progenitor cells. [Proc Natl Acad Sci USA] Full Article | Press Release SKELETAL MUSCLE CELLSStructural Basis of Laminin Binding to the LARGE Glycans on Dystroglycan Like-acetylglucosaminyltransferase (LARGE) synthesizes the matrix-binding heteropolysaccharide [-glucuronic acid-β1,3-xylose-α1,3-]n. Using a dual exoglycosidase digestion, investigators confirmed that this polysaccharide is present on native α-dystroglycan from skeletal muscle. [Nat Chem Biol] Abstract Researchers examined the role of STAT3 in muscle satellite cells (MuSCs) using two different mouse models: a MuSC-specific Stat3 knockout line and a Stat3 (MuSC-specific)/dystrophin double knockout line. [Cell Rep] Full Article | Graphical Abstract The authors aimed to provide in vitro quantitative evidence of the ability of mesoangioblasts to restore dystrophin, in terms of protein accumulation and distribution, within myotubes derived from Duchenne muscular dystrophy patients, using a microengineered model. [Stem Cells Transl Med] Abstract Investigators performed comprehensive cell-surface protein profiling of the two progenitor populations residing in human skeletal muscle and identified three previously unrecognized markers: CD82 and CD318 for satellite cells and CD201 for mesenchymal progenitors. [Stem Cell Reports] Full Article | Graphical Abstract DNA-PK Activity Is Associated with Caspase-Dependent Myogenic Differentiation Differentiation of myoblasts into myotubes is essential for skeletal muscle development and regeneration. Investigators showed that inhibition of DNA-PK, but not of ATR or ATM, blocked histone phosphorylation during differentiation. They also showed that DNA-PK inhibition and siRNA-mediated DNA-PK knockdown blocked cell fusion. [FEBS J] Abstract The authors showed that HIRA is phosphorylated by Akt kinase, an important signaling modulator in muscle cells. By generating a phosphospecific antibody, they found that a significant amount of HIRA was phosphorylated in myoblasts. [Exp Mol Med] Full Article SMOOTH MUSCLE CELLSResearchers explored the mechanistic links between micoRNA-34b/c and aldosterone in vascular smooth muscle cell calcification. [Cell Tissue Res] Abstract | |
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REVIEWSSpatiotemporal Regulation of Enhancers during Cardiogenesis With the advance in chromatin immunoprecipitation followed by high-throughput sequencing, there has been a dramatic increase in our understanding of distal enhancer function. In the developing heart, the identification and characterization of such enhancers have deepened our knowledge of the mechanisms of transcriptional regulation that drives cardiac differentiation. [Cell Mol Life Sci] Full Article Visit our reviews page to see a complete list of reviews in the muscle cell research field. | |
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INDUSTRY NEWSWorcester Polytechnic Institute Receives $968,000 NIH Grant for Heart Cell Study The National Institutes of Health (NIH) has awarded a four-year, $968,000 grant to a biomedical research team at Worcester Polytechnic Institute exploring the molecular signals of a heart under stress to better understand the mechanisms of cardiac diseases. [Worcester Polytechnic Insitute] Press Release Tivorsan Pharmaceuticals, Inc. announced that the U.S. Food and Drug Administration (FDA) has granted Orphan Drug Designation to its lead investigational drug, human recombinant Biglycan, for the treatment of Duchenne Muscular Dystrophy. [Tivorsan Pharmaceuticals (Business Wire)] Press Release | |
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POLICY NEWSNIH Sets New Postdoc Stipend Levels In response to a new rule governing overtime pay in the United States, the National Institutes of Health announced its new, increased postdoc stipend levels, which will go into effect 1 December 2016. [Science Careers] Editorial | Notice Beyond CRISPR: A Guide to the Many Other Ways to Edit a Genome The zeal with which researchers jumped on a possible new gene-editing system called NgAgo earlier this year reveals an undercurrent of frustration with CRISPR–Cas9 — and a drive to find alternatives. [Nature News] Editorial The FDA Is Prohibited from Going Germline A potentially renewable provision of the Consolidated Appropriation Act of 2016 forestalling the prospect of human germline modification was signed into law on December 18th, 2015. The provision has since been incorporated again into the House and Senate appropriation bills for the fiscal year. [ScienceInsider] Editorial
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EVENTSNEW Symposium on Regenerative Rehabilitation Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Research Technician – Muscle Growth and Wasting (Howard Hughes Medical Institute) NEW Research Associate – Lipid Metabolism (Wright State University, Boonshoft School of Medicine) Postdoctoral Position – Cardiovascular Stem Cell Biology (Yale University) Postdoctoral Research Fellowship – Functional Genomics and Bioinformatics (L’Institut du Thorax) Postdoctoral Position – Biomedical Engineering (University of South Dakota) Postdoctoral Position – Duchenne Muscular Dystrophy (Leiden University Medical Center) Postdoctoral Fellow – Muscle Energetics (National Institutes of Health) Post-Doc/Associate Specialist – Autophagy (Nestlé Institute of Health Sciences) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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Home Muscle Cell News Volume 1.21 | Aug 15 2016