Muscle Cell News 2.13 April 17, 2017 | |
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TOP STORYHigh-Resolution Myogenic Lineage Mapping by Single-Cell Mass Cytometry Researchers capitalized on a transformative technology, single-cell mass cytometry, and identified in vivo skeletal muscle stem cell and previously unrecognized progenitor populations that precede differentiation. They discovered two cell surface markers, CD9 and CD104, whose combined expression enabled in vivo identification and prospective isolation of stem and progenitor cells. [Nat Cell Biol] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)CARDIAC MUSCLE CELLSMyeloperoxidase Mediates Postischemic Arrhythmogenic Ventricular Remodeling The authors investigated the role of myeloperoxidase (MPO) for the development of ventricular arrhythmias. In different murine models of myocardial ischemia, MPO deficiency profoundly decreased vulnerability for ventricular tachycardia upon programmed right ventricular and burst stimulation and spontaneously as assessed by ECG telemetry following isoproterenol injection. [Circ Res] Abstract Researchers investigated the relationship between the duration of exposure to the pro-hypertrophic G-protein coupled receptor agonist endothelin-1 and the induction of hypertrophic remodeling in neonatal rat ventricular myocytes and in the adult rat heart in vivo. [Cell Signal] Abstract CRISPR-Cpf1 Correction of Muscular Dystrophy Mutations in Human Cardiomyocytes and Mice Investigators deployed Cpf1, a unique class 2 clustered regularly interspaced short palindromic repeats (CRISPR) effector, to correct X-linked dystrophin gene mutations in patient-derived induced pluripotent stem cells and mdx mice, an animal model of Duchenne muscular dystrophy. [Sci Adv] Full Article | Press Release SKELETAL MUSCLE CELLSDysferlinopathy Promotes an Intramuscle Expansion of Macrophages with a Cyto-Destructive Phenotype Scientists investigated in vitro macrophage-myogenic cell interactions and found that Dysf-deficient muscle i) promotes macrophage proliferation, ii) skews macrophages toward a cyto-destructive phenotype, and iii) is more vulnerable to macrophage-mediated apoptosis. [Am J Pathol] Abstract The authors tested whether loss of physiological Ca2+ transients is an initial cause leading to mitochondrial dysfunction in denervated skeletal muscle. They found that muscle fibers showed a fourfold increase in mitoflash activity 24 hours after denervation. [Skelet Muscle] Full Article SMOOTH MUSCLE CELLSScientists described a novel antiapoptotic mechanism in vascular smooth muscle cell that involves interaction of nuclear glyceraldehyde-3-phosphate dehydrogenase (GAPDH) with apurinic/apyrimidinic endonuclease 1, the major oxidized DNA repair enzyme. GAPDH down-regulation potentiated H2O2-induced DNA damage and SMC apoptosis. [FASEB J] Abstract The authors sought to verify whether myostatin (Mstn) is operative in atherosclerosis of abdominal aorta. In human specimens, Mstn expression was almost absent in normal vessels, but became detectable in the media of non-progressive lesions and increased with the severity of the damage. [Sci Rep] Full Article Researchers investigated the effects of synthetic cyclic peptide *CRRETAWAC* on fibronectin-induced cytokine secretion of airway smooth muscle cells and the underlying mechanism. [J Cell Mol Med] Full Article Investigators tested whether fatty acid-binding protein (FABP)4 plays a role in the pathogenesis of hypertension development including proliferation, migration, and inflammation of vascular smooth muscle cells (SMCs) as well as contractile reactivity. FABP4 alone had no influence on proliferation, migration, and inflammation of rat mesenteric arterial SMCs, while it significantly enhanced smooth muscle contraction and increases of systolic blood pressure induced by noradrenaline. [Pflugers Arch] Abstract | |
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REVIEWSCardiac Pathology in Spinal Muscular Atrophy: A Systematic Review The authors systematically reviewed reported cardiac pathology in relation to survival motor neuron deficiency. They used clinical classification systems to characterize structural cardiac defects and arrhythmias. [Orphanet J Rare Dis] Full Article Visit our reviews page to see a complete list of reviews in the muscle cell research field. | |
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INDUSTRY NEWSMesoblast Limited announced that the Phase III trial of its allogeneic mesenchymal precursor cell (MPC) product candidate MPC-150-IM in patients with moderate to advanced chronic heart failure was successful in the pre-specified interim futility analysis of the efficacy endpoint in the trial’s first 270 patients. [Mesoblast Limited] Press Release UW Treats First Participant in Trial of Stem-Cell Therapy for Heart Failure A research team at University of Wisconsin (UW) School of Medicine and Public Health has treated its first patient in an innovative clinical trial using stem cells for the treatment of heart failure that develops after a heart attack. [University of Wisconsin School of Medicine and Public Health] Press Release | |
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POLICY NEWSWith This New System, Scientists Never Have to Write a Grant Application Again Almost every scientist agrees: Applying for research funding is a drag. Writing a good proposal can take months, and the chances of getting funded are often slim. Funding agencies, meanwhile, spend more and more time and money reviewing growing stacks of applications. That’s why two researchers are proposing a radically different system that would do away with applications and reviews; instead scientists would just give each other money. [ScienceInsider] Editorial Joining the European Union Leads to Less Cross-Border Collaboration When the European Union expanded in the 2000s, it had a negative impact on scientific collaborations between researchers in new member countries and elsewhere, a study has found. [Nature News] Editorial
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EVENTSNEW Gordon Research Conferences: Myogenesis Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Research Fellow – Cardiovascular Science (Columbia University) NEW PhD Studentship – Cardiac Regeneration (Max Delbruck Center for Molecular Medicine) Principal Investigator – Human Physiology and Experimental Medicine (University of Cambridge) Postdoctoral Fellow – Cardiovascular Disease (Icahn School of Medicine at Mount Sinai) Postdoctoral Fellow – Vascular Smooth Muscle (The University of Tennessee Health Science Center) Postdoctoral Fellow – Skeletal Muscle (University of Oregon) Postdoctoral Scholar – Stem Cell Biology and Endocrinology (Stanford University) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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Home Muscle Cell News Volume 2.13 | Apr 17 2017