Muscle Cell News 3.11 April 2, 2018 | |
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TOP STORYThe authors found that miR-1/133a downregulates Mef2A in differentiated myocytes, thereby suppressing the Dlk1–Dio3 gene cluster, which encodes multiple microRNAs inhibiting expression of mitochondrial genes. [Cell Metab] Abstract | Graphical Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)CARDIAC MUSCLE CELLSAblation of the Stress Protease OMA1 Protects against Heart Failure in Mice Scientists evaluated three different mouse models of heart failure (HF): tachycardiomyopathy, HF with preserved left ventricular (LV) ejection fraction (LVEF), and LV myocardial ischemia and hypertrophy. Regardless of whether LVEF was preserved, their results indicate that the three models share common features: an increase in mitochondrial reactive oxygen species followed by ultrastructural alterations in the mitochondrial cristae and loss of mitochondrial integrity that lead to cardiomyocyte death. [Sci Transl Med] Abstract | Press Release Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) grown in engineered heart tissue (EHT) can be used for drug screening, disease modeling, and heart repair. However, the immaturity of hiPSC-CMs currently limits their use. Because mechanical loading increases during development and facilitates cardiac maturation, researchers hypothesized that afterload would promote maturation of EHTs. [J Mol Cell Cardiol] Abstract | Graphical Abstract Bioinspired Living Structural Color Hydrogels Inspired by the structural color regulation mechanism of chameleons, scientists present a conceptually different structural color material that has autonomic regulation capability by assembling engineered cardiomyocyte tissues on synthetic inverse opal hydrogel films. [Sci Robot] Abstract | Editorial SKELETAL MUSCLE CELLSp110α of PI3K Is Necessary and Sufficient for Quiescence Exit in Adult Muscle Satellite Cells Investigators demonstrated that inducible muscle satellite cell (MuSC)‐specific deletion of p110α, a catalytic subunit of phosphatidylinositol 3‐kinase (PI3K), rendered MuSCs unable to exit quiescence, resulting in severely impaired MuSC proliferation and muscle regeneration. [EMBO J] Abstract | Graphical Abstract Researchers found that miR-107 expression was high in skeletal muscle of Qinchuan cattle. Overexpression of miR-107 inhibited bovine myoblasts differentiation and protected cells from apoptosis. [Mol Ther Nucleic Acids] Full Article The authors demonstrated that FoxM1 was essential for the proliferation and survival of satellite cells (SCs). Crucially, they found that long noncoding RNAs (lncRNAs) Snhg8 and Gm26917 significantly regulated the proliferation and apoptosis of SCs, respectively, and these lncRNAs were directly regulated by FoxM1 in SCs. [Stem Cells] Abstract SMOOTH MUSCLE CELLSScientists defined the mechanisms by which mitochondria control vascular smooth muscle cell (VSMC) migration and impact neointimal hyperplasia. The multifunctional CaMKII in the mitochondrial matrix of VSMC drove a feed-forward circuit with the mitochondrial Ca2+ uniporter to promote matrix Ca2+ influx. [Arterioscler Thromb Vasc Biol] Abstract The authors tested the hypothesis that vascular smooth muscle cells (VSMCs) contribute to aortic stiffening through their extracellular effects. Reconstituted vessel segments made with spontaneously hypertensive rat VSMCs were significantly stiffer than vessels made with Wistar‐Kyoto rat VSMCs. [Aging Cell] Full Article Researchers propose a novel role for the mineralization regulator Ucma/GRP (Upper zone of growth plate and Cartilage Matrix Associated protein/Gla Rich Protein) in phosphate-induced vascular smooth muscle cell (VSMC) calcification. They showed that Ucma/GRP is present in calcified atherosclerotic plaques and highly expressed in calcifying VSMCs in vitro. [Sci Rep] Full Article | |
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REVIEWSProtein Availability and Satellite Cell Dynamics in Skeletal Muscle The authors review the molecular mechanisms controlling the activation of satellite cells in response to mechanical stress and protein intake in both in vitro and in vivo models. [Sports Med] Abstract Visit our reviews page to see a complete list of reviews in the muscle cell research field. | |
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INDUSTRY NEWSMYOS RENS Technology, Inc. announced that it has entered into a research agreement with Rutgers University to engage Rutgers researchers in a program focused on discovering compounds and products for promoting the growth and development of muscle tissue. [MYOS RENS Technology Inc.] Press Release Scholar Rock announced that the FDA has granted Orphan Drug Designation to its lead antibody product candidate, SRK-015, for the treatment of spinal muscular atrophy. [Scholar Rock, Inc.] Press Release | |
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POLICY NEWSIn Emotional Speech, CDC’s New Leader Vows to Uphold Science Robert Redfield Jr., the new director of the Centers for Disease Control and Prevention (CDC), gave a deeply personal agencywide address in which he repeatedly underscored the importance of science and data and said the CDC’s most critical public health mission is to protect Americans “from that which we don’t expect.” [The Washington Post] Editorial Cancer Researcher at the Ohio State University Resigns following Multiple Misconduct Findings A cancer researcher has resigned from The Ohio State University in Columbus after the institution determined he had committed misconduct in eight papers. His work in designing anticancer compounds had led to millions of dollars in funding and multiple patents, as well as two compounds in clinical trials. [ScienceInsider] Editorial
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EVENTSNEW Aegean Conferences: 2nd International Conference on Tissue Repair, Regeneration, and Fibrosis Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Fellow – Smooth Muscle Cells (University of Colorado) Postdoctoral Research Scientist – Regenerative Medicine (University of Oxford) Research Associate – Vascular Smooth Muscle Cells (University of Bristol) Postdoctoral Researcher – Molecular Cardiology (National Center for Cardiovascular Research) Postdoctoral Position – Cancer, Immunotherapy, and Fibrosis (University of Alabama at Birmingham) Postdoctoral Research Assistant – Cardiovascular Medicine (University of Oxford) Director – Whitaker Cardiovascular Institute (Boston University) Postdoctoral Fellowship – Basic and Translational Heart Failure (University of South Florida) Fellowship – Cardio-Biology (Johns Hopkins University) Postdoctoral Associate – Bioengineering (University of Pittsburgh) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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