Burkholderia pseudomallei Survival in Lung Epithelial Cells Benefits from miRNA-Mediated Suppression of ATG10 Based on microarray screening, scientists found that ATG10 was downregulated following B. pseudomallei infection in A549 human lung epithelial cells. Forced expression of ATG10 accelerated the elimination of intracellular B. pseudomallei by enhancing the process of autophagy. [Autophagy] Abstract Mono- and Cocultures of Bronchial and Alveolar Epithelial Cells Respond Differently to Proinflammatory Stimuli and Their Modulation by Salbutamol and Budesonide Researchers investigated the changes in transport and effectiveness of salbutamol sulfate and budesonide following stimulation with transforming growth factor-β in mono- and coculture models of bronchial and alveolar epithelium. [Mol Pharm] Abstract | Graphical Abstract Junctional Abnormalities in Human Airway Epithelial Cells Expressing delF508 CFTR The authors examined changes to CFTR function, tight junctions, and gap junctions in NuLi-1 and CuFi-5. Cells were studied at air-liquid interface and compared to primary human bronchial epithelial cells. [Am J Physiol Lung Cell Mol Physiol] Abstract Modulation of Cytokines and Chemokines Expression by NAC in Cadmium Chloride Treated Human Lung Cells Researchers studied the immunomodulatory effect of a well-known antioxidant, N-acetylcysteine (NAC) on cadmium chloride treated human lung A549 cells through human cytokine array 6. [Environ Toxicol] Abstract LUNG CANCER RhoB Loss Induces Rac1-Dependent Mesenchymal Cell Invasion in Lung Cells through PP2A Inhibition Scientists identified the small GTPase RhoB as a key regulator of bronchial cell morphology in a three-dimensional (3D) matrix. RhoB loss, which is frequently observed during lung cancer progression, induced an epithelial-mesenchymal transition characterized by an increased proportion of invasive elongated cells in 3D. [Oncogene] Abstract Neuropilin 1 Expression Correlates with the Radio-Resistance of Human Non-Small-Cell Lung Cancer Cells Investigators determined the correlation between over-expression of the neuropilin 1 gene and growth, survival, and radio-sensitivity of non-small cell lung carcinoma cells. [J Cell Mol Med] Full Article The Topoisomerase 1 Inhibitor Austrobailignan-1 Isolated from Koelreuteria henryi Induces a G2/M-Phase Arrest and Cell Death Independently of p53 in Non-Small Cell Lung Cancer Cells Researchers showed that austrobailignan-1 inhibited cell growth of human non-small cell lung cancer A549 and H1299 cell lines in both dose- and time-dependent manners, the IC50 value of austrobailignan-1 were 41 and 22 nM, respectively. [PLoS One] Full Article MicroRNA-410 Promotes Cell Proliferation by Targeting BRD7 in Non-Small Cell Lung Cancer The authors showed that the expression of miR-410 was up-regulated in both human NSCLC tissues and cells. Overexpression of miR-410 promoted cell proliferation, migration, and invasion of NSCLC. [FEBS Lett] Abstract |