Pulmonary Cell News Volume 4.34 | Sep 3 2015

WNT/β-Catenin Signaling Regulates Cigarette Smoke-Induced Airway Inflammation via the PPARδ/p38 Pathway
Scientists investigated the role of WNT/β-catenin signaling in cigarette smoke-related airway inflammation using patient lung tissues, human bronchial epithelial cells, and mouse models. [Lab Invest] Abstract

Nobiletin Stimulates Chloride Secretion in Human Bronchial Epithelia via a cAMP/PKA-Dependent Pathway
Researchers examined the effects of nobiletin on basal short-circuit current in a human bronchial epithelial cell line, and characterized the signal transduction pathways that allowed nobiletin to regulate electrolyte transport. [Cell Physiol Biochem] Abstract

Verproside Inhibits TNF-α-Induced MUC5AC Expression through Suppression of the TNF-α/NF-κB Pathway in Human Airway Epithelial Cells
Scientists found that verproside significantly reduces the expression levels of tumor necrosis factor alpha (TNF-α)-induced MUC5AC mRNA and protein by inhibiting both nuclear factor kappa B (NF-κB) transcriptional activity and the phosphorylation of its upstream effectors such as IκB kinaseβ, IκBα, and TGF-β-activated kinase 1 in NCI-H292 cells. [Cytokine] Abstract

LUNG CANCER

Retinoic Acid-Related Orphan Receptor C Isoform 2 Expression and Its Prognostic Significance for Non-Small Cell Lung Cancer
The authors analyzed the expression of retinoic acid-related orphan receptor C isoform 2 (RORC2) and its participation in tumor progression in non-small cell lung cancer (NSCLC). RORC2 expression in NSCLC cell lines was examined by qRT-PCR, Western blotting and flow cytometry. The effects of inhibiting RORC2 activity on the proliferation of NSCLC cells were evaluated. [J Cancer Res Clin Oncol] Abstract

MicroRNA-181a Regulates Epithelial-Mesenchymal Transition by Targeting PTEN in Drug-Resistant Lung Adenocarcinoma Cells
Paclitaxel- and cisplatin-resistant A549 lung carcinoma cell derivatives were developed by long-term serial culture. To identify novel regulators of epithelial-mesenchymal transition in A549 cells, differentially expressed miRNAs in drug-resistant cells were identified by microarray analysis. [Int J Oncol] Abstract

Up-Regulation of miR-452 Inhibits Metastasis of Non-Small Cell Lung Cancer by Regulating BMI1
Relatively lower microRNA (miR)-452 and higher BMI1 expression levels were confirmed to be associated with advanced tumor stage and more extent of lymph nodes metastasis. In vitro, down-regulated miR-452 enhanced cell invasion capability. [Cell Physiol Biochem] Abstract

Promoting Roles of the Secreted Frizzled-Related Protein 2 as a Wnt Agonist in Lung Cancer Cells
Scientists employed the secreted frizzled-related protein 2 (SFRP2)-overexpressing plasmid and siRNA to transfect A549 and 95-D cells, respectively. Through MTT assays, they found that SFRP2 knockdown inhibited cell proliferation, and halted the 95-D cells in G1 phase of the cell cycle by downregulation of CCND1 and CDK4, indicating that SFRP2 has the ability of promoting lung cancer cell proliferation. [Oncol Rep]
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Ignyta Announces Entrectinib Clinical Case Report Presentation
Ignyta, Inc. announced that an abstract relating to entrectinib, the company’s proprietary oral tyrosine kinase inhibitor targeting solid tumors that harbor activating alterations to TrkA, TrkB, TrkC, ROS1 or ALK, has been selected for a mini-oral presentation. [Press release from Ignyta, Inc. discussing research to be presented at the 16^th World Conference on Lung Cancer, Denver] Press Release

Bristol-Myers Squibb to Present New Data from its Immuno-Oncology Clinical Development Programs
Bristol-Myers Squibb Company announced that data from its immuno-oncology clinical development programs will be presented. The company is presenting Opdivo (nivolumab) data in a broad set of patients with lung cancer, across histologies and treatment settings. [Press release from Bristol-Myers Squibb Company (Business Wire) discussing research to be presented at the 16^th World Conference on Lung Cancer, Denver] Press Release

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U.S. Food and Drug Administration Accepts Supplemental Biologics License Application for Opdivo (Nivolumab) in Previously Treated Non-Squamous Non-Small Cell Lung Cancer Patients
Bristol-Myers Squibb Company announced that the U.S. Food and Drug Administration has accepted for filing and review the supplemental Biologics License Application for Opdivo for the treatment of previously treated patients with non-squamous non-small cell lung cancer. [Bristol-Myers Squibb Company] Press Release

OSE Pharma Sets Up Scientific Steering Committee and Takes a First Step in the Launch of Its Phase III Trial in Lung Cancer
OSE Pharma SA, a biotechnology company based in France that is developing T-specific immunotherapy treatments against invasive and metastatic cancers, announced the formation of its International Scientific Steering Committee as a part of the launch of its pivotal Phase III trial of Tedopi^® by the end of the year. [OSE Pharma SA (Business Wire)] Press Release

UC San Diego Cancer Researchers Receive NCI Outstanding Investigator Award
Four University of California, San Diego School of Medicine researchers have been selected to receive the newly established National Cancer Institute (NCI) Outstanding Investigator Award. The multi-million dollar awards fund new projects that have an unusual potential in cancer research over seven years. [UC San Diego] Press Release

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

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NEW Postdoctoral Fellow – Lung Cancer (Van Andel Research Institute)

Scientist – Pluripotent Stem Cell Biology Endoderm Lineages (STEMCELL Technologies Inc.)

Postdoctoral Fellow – Pulmonary Biology (The University of Alabama)

Postdoctoral Research Fellow – Cancer and Molecular Imaging (University of Michigan)

Postdoctoral Fellow – HMGA Chromatin Remodeling Proteins in Cancer and Stem Cell Biology (Johns Hopkins University School of Medicine)

Senior Research Technician (Qu Biologics Inc.)

Postdoctoral Research Associate – Airway Diseases (GlaxoSmithKline)

Harry Eagle Scholar Awards for Postdoctoral Candidates (Albert Einstein College of Medicine of Yeshiva University)

Postdoctoral Positions – Cancer Research (Rutgers University)

Postdoctoral Fellow – Cancer Research (National University of Singapore)

Postdoctoral Fellow – Pulmonary Fibrosis (University of Colorado School of Medicine)

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