Salidroside Protects against Bleomycin-Induced Pulmonary Fibrosis: Activation of Nrf2-Antioxidant Signaling, and Inhibition of NF-κB and TGF-β1/Smad-2/-3 Pathways Investigators explored the therapeutic effects of salidroside on pulmonary fibrosis. Salidroside was capable of reversing the recombinant TGF-β1-induced epithelial-mesenchymal transition-like changes in alveolar epithelial cells in vitro. [Cell Stress Chaperones] Abstract Role of Pro-inflammatory Cytokines in Radiation-Induced Genomic Instability in Human Bronchial Epithelial Cells Scientists investigated whether IL-8 induction is part of a broader pro-inflammatory response produced by epithelial cells in response to damage, which influences genomic instability measured by increased micronuclei and DNA repair foci frequencies. [Radiat Res] Abstract Nontypeable Haemophilus influenzae Exploits the Interaction between Protein-E and Vitronectin for the Adherence and Invasion to Bronchial Epithelial Cells The authors hypothesized that protein-E, an outer membrane protein of nontypeable H. influenzae (NTHi), plays a role in this penetration into bronchial epithelial cells. NTHi strains invaded bronchial epithelial cells and the intracellular bacteria were localized in early endosomes. [BMC Microbiol] Full Article LUNG CANCER Overexpression of Major CDKN3 Transcripts Is Associated with Poor Survival in Lung Adenocarcinoma The authors analyzed cyclin-dependent kinase inhibitor 3 (CDKN3) expression and its association with patient survival in three cohorts of lung adenocarcinoma. CDKN3 transcripts were further analyzed in a panel of cell lines and lung adenocarcinoma tissues. [Br J Cancer] Abstract miR-411 Contributes the Cell Proliferation of Lung Cancer by Targeting FOXO1 Scientists found miR-411 was overexpressed in lung cancer cells; overexpression of miR-411 promoted anchorage-dependent and anchorage-independent growths of lung cancer, while miR-411 knockdown reduced this effect. [Tumor Biol] Abstract MET Gene Amplification and MET Receptor Activation Are Not Sufficient to Predict Efficacy of Combined MET and EGFR Inhibitors in EGFR TKI-Resistant NSCLC Cells Researchers described the establishment and characterization of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI)-resistant non-small cell lung cancer (NSCLC) cell lines and a pilot study on the effects of a combined MET and EGFR inhibitors treatment. [PLoS One] Full Article Tangeretin Derivative, 5-Acetyloxy-6,7,8,4′-Tetramethoxyflavone Induces G2/M Arrest, Apoptosis and Autophagy in Human Non-Small Cell Lung Cancer Cells In Vitro and In Vivo The authors investigated the anticancer effects of 5-acetyloxy-6,7,8,4′-tetramethoxyflavone on CL1-5 non-small cell lung cancer cells both in vitro and in vivo. [Cancer Biol Ther] Abstract Digitoxin and Its Synthetic Analog MonoD Have Potent Antiproliferative Effects on Lung Cancer Cells and Potentiate the Effects of Hydroxyurea and Paclitaxel Investigators evaluated the in vitro antiproliferative activity of the cardiac glycoside digitoxin and its synthetic analog MonoD on H460 lung cancer cells grown under different culture conditions. [Oncol Rep] Abstract |