Specific Regulation of PRMT1 Expression by PIAS1 and RKIP in BEAS-2B Epithelia Cells and HFL-1 Fibroblasts in Lung Inflammation Researchers investigated the cell type specific regulatory mechanism of protein arginine methyltransferase 1 (PRMT1). Epithelial cells and fibroblasts were stimulated with IL-4 or IL-1β. [Sci Rep] Full Article Oxidative Stress Pathways Involved in Cytotoxicity and Genotoxicity of Titanium Dioxide (TiO2) Nanoparticles on Cells Constitutive of Alveolo-Capillary Barrier In Vitro The effect of titanium dioxide nanoparticles was examined on cell lines representative of alveolo-capillary barrier. Scientists showed that all nanoparticles-exposed cell lines displayed ROS generation. Macrophage-like THP-1 and HPMEC-ST1.6R microvascular cells were sensitive to endogenous redox changes and underwent apoptosis, but not alveolar epithelial A549 cells. [Toxicol In Vitro] Abstract Pleurotus nebrodensis Polysaccharide (PN50G) Evokes A549 Cell Apoptosis by the ROS/AMPK/PI3K/AKT/mTOR Pathway to Suppress Tumor Growth Since the strong antineoplastic potential against A549 cells of PN50G in vitro has been proven previously, the definitive mechanism of PN50G-induced apoptosis in A549 cells in vivo was investigated. [Food Funct] Abstract Involvement of B-Cell CLL/Lymphoma 2 Promoter Methylation in Cigarette Smoke Extract-Induced Emphysema Researchers determined whether the anti-apoptotic B-cell CLL/lymphoma 2 (Bcl-2) play a role in the cigarette smoke extract-induced emphysema. Furthermore, given the involvement of epigenetics in chronic obstructive pulmonary disease, they hypothesized that the deregulation of Bcl-2 might be caused by gene methylation. [Exp Biol Med] Abstract LUNG CANCER Human Lung Adenocarcinoma Cell Cultures Derived from Malignant Pleural Effusions as Model System to Predict Patients Chemosensitivity Using malignant pleural effusions from non-small cell lung cancer patients, scientists established a collection of patient-derived adenocarcinoma cultures which were characterized for their sensitivity to chemotherapeutic drugs used in the clinical practice. [J Transl Med] Full Article More Expression of BDNF Associates with Lung Squamous Cell Carcinoma and Is Critical to the Proliferation and Invasion of Lung Cancer Cells The authors explored the function of brain-derived neurotrophic factor (BDNF) in lung squamous cell carcinoma and adenocarcinoma. BDNF expression was also evaluated in human bronchial epithelial cells and four lung cancer cell lines using western blot. [BMC Cancer] Full Article Cyclopamine Tartrate, an Inhibitor of Hedgehog Signaling, Strongly Interferes with Mitochondrial Function and Suppresses Aerobic Respiration in Lung Cancer Cells To find novel strategies for combating lung cancer, investigators characterized the effect of cyclopamine tartrate, an improved analogue of cyclopamine, on lung cancer cells and its mechanism of action. [BMC Cancer] Full Article BMS-754807 Is Cytotoxic to Non-Small Cell Lung Cancer Cells and Enhances the Effects of Platinum Chemotherapeutics in the Human Lung Cancer Cell Line A549 The dual type I insulin-like growth factor receptor/insulin receptor inhibitor, BMS-754807, was evaluated alone and in combination with platinum-based chemotherapeutics in two human non-small cell lung cancer cell lines. [BMC Res Notes] Full Article |