Pulmonary Cell News 7.01 January 11, 2018 | |
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TOP STORYThe ATF4 target asparagine synthetase contributed to apoptotic suppression, protein biosynthesis, and mTORC1 activation. Inhibition of AKT suppressed ASNS expression and, combined with depletion of extracellular asparagine, decreased tumor growth. [Cancer Cell] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)House Dust Mite Impairs Antiviral Response in Asthma Exacerbation Models through Its Effects on TLR3 Experimental asthma exacerbations were produced in vitro in human bronchial epithelial cells and in mice by using sequential challenges with house dust mite and a viral infection mimic, Poly(I:C). [Allergy] Abstract Treatment with sodium tanshinone IIA sulfonate reduced cigarette smoke extract-induced interleukin (IL)-6 and IL-8 secretion in human bronchial epithelial cells. [Sci Rep] Full Article The authors used a phenotypic approach to identify new biological and chemical starting points for inhibition of thymic stromal lymphopoietin (TSLP) production in human bronchial epithelial cells, with the objective of reducing T helper 2 lymphocyte-mediated airway inflammation. [PLoS One] Full Article LUNG CANCERInvestigators found inactivating mutations and homologous or hemizygous deletions in the CHUK locus, which encodes IκB kinase α (IKKα), in human lung adenocarcinomas. [Proc Natl Acad Sci USA] Full Article Scientists employed multiple isogenic retinoblastoma tumor suppressor (RB) proficient and deficient non-small cell lung cancer lines to interrogate the cytostatic and cytotoxic capacity of CDK 4/6 inhibition in vitro and in vivo. [Clin Cancer Res] Abstract AATF Suppresses Apoptosis, Promotes Proliferation and Is Critical for Kras-Driven Lung Cancer The authors showed that replication stress occurs in Kras-driven murine lung adenocarcinomas, as well as in proliferating murine embryonic and adult tissues. [Oncogene] Abstract Nanofiber Membrane Supported Lung-on-a-Chip Microdevice for Anti-Cancer Drug Testing Taking the alveolar microenvironment as a model, researchers developed a lung-on-a-chip with a poly(lactic-co-glycolic acid) electrospinning nanofiber membrane as the chip substrate and cell scaffold. [Lab Chip] Abstract | Graphical Abstract Enhanced YAP Expression Leads to EGFR TKI Resistance in Lung Adenocarcinomas Scientists investigated the roles of Yes-associate protein (YAP) in tyrosine kinase inhibitor (TKI)-resistant lung adenocarcinoma. In TKI-sensitive cells, enhanced YAP expression lead to TKI resistance. Also, upregulated YAP expression and activation were detected in long-term TKI-induced resistant cells. [Sci Rep] Full Article | |
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REVIEWSInteractions between EGFR and PD-1/PD-L1 Pathway: Implications for Treatment of NSCLC The authors discussed the regulation effect of epidermal growth factor receptor (EGFR) signaling on programmed cell death receptor/ligand 1 (PD-1/PD-L1) pathway and the potential mechanisms behind combing EGFR-tyrosine kinase inhibitors with PD-1/PD-L1 inhibitors. [Cancer Lett] Abstract Visit our reviews page to see a complete list of reviews in the pulmonary cell research field. | |
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INDUSTRY NEWSBerGenBio ASA announced that the first efficacy endpoint has been met in its Phase II clinical trial evaluating BGB324, a selective AXL inhibitor, in combination with erlotinib in patients with advanced non-small cell lung cancer (NSCLC) who have progressed on an approved epidermal growth factor receptor inhibitor. [BerGenBio ASA] Press Release Vertex Pharmaceuticals Inc. announced that the European Commission has granted extension of the Marketing Authorization for ORKAMBI®, the first medicine to treat the underlying cause of CF in people with two copies of the F508del mutation, to include children ages 6 through 11. [Vertex Pharmaceuticals Inc.] Press Release | |
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POLICY NEWSRising Star Appointed UK Science Minister The United Kingdom has gained a new science minister as part of a broader reshuffle of government posts. Sam Gyimah, who moves from the Ministry of Justice, was appointed minister for universities and science, replacing Jo Johnson. [Nature News] Editorial Faced with Public Pressure, Research Institutions Step Up Reporting of Clinical Trial Results The reporting of clinical trial results to a public database — mandated by a ten-year-old federal law — has improved sharply in the last two years, with universities and other nonprofit research centers leading the way. [STAT News] Editorial
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EVENTSNEW Applications of Organoid Technology Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Scholarship – Translational Cancer Stem Cell Biology (Lund University) NEW Postdoctoral Position – Pulmonary Disease Pathogenesis (Columbia University) NEW Postdoctoral Training Fellow – Lung Cancer (The Francis Crick Institute) Postdoctoral Fellow – Lung Regeneration after Injury (University of Michigan) Postdoctoral Fellow – Lung Cancer (MD Anderson Cancer Center) Postdoctoral Position – Cell Signaling and Cell Differentiation (Stanford University) Postdoctoral Researcher – Cancer Research (University of California, Davis) Postdoctoral Fellow – Human Airway Stem Cell Biology (Cornell University) PhD Studentship – Heterogeneity in Small Cell Lung Cancer (CRUK Manchester Institute) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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