Pulmonary Cell News 8.01 January 17, 2019 | |
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TOP STORYHSP90 Inhibitor Geldanamycin Reverts IL-13- and IL-17-Induced Airway Goblet Cell Metaplasia Investigators confirmed that geldanamycin and other HSP90 inhibitors prevented IL-13-induced goblet cell metaplasia in vitro and in vivo. Geldanamycin did not induce goblet cell death, nor did it solely block mucin synthesis or IL-13 receptor-proximal signaling. Geldanamycin affected the transcriptome of airway cells when exposed to IL-13, but not when exposed to vehicle. [J Clin Invest] Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)Long-Term Expanding Human Airway Organoids for Disease Modeling Scientists describe a method to establish long-term-expanding human airway organoids from broncho-alveolar resections or lavage material. The pseudostratified airway organoids consisted of basal cells, functional multi-ciliated cells, mucus-producing secretory cells, and CC10-secreting club cells. Airway organoids derived from CF patients allowed assessment of CFTR function in an organoid swelling assay. [EMBO J] Full Article | Graphical Abstract YAP1/Twist Promotes Fibroblast Activation and Lung Fibrosis That Conferred by miR-15a Loss in IPF Knockdown of miR-15a resulted in fibroblast activation and lung fibrosis through promoting Twist expression by targeting inhibition of YAP1. In contrast, therapeutic restoration of miR-15a inhibited fibrogenesis in lung fibroblast and abrogated BLM-induced lung fibrosis in mice. [Cell Death Differ] Abstract The authors demonstrated that hypercapnic acidosis attenuated the inflammatory response and reparative potential of primary human small airway epithelium and capillary endothelium and induced mitochondrial dysfunction. [FASEB J] Abstract LUNG CANCERLUBAC Determines Chemotherapy Resistance in Squamous Cell Lung Cancer KF lung squamous cell carcinoma (LSCC) tumors recapitulated human LSCC resistance to cisplatin-based chemotherapy, and scientists identified LUBAC-mediated NF-κB signaling as a determinant of chemotherapy resistance in human and mouse. Inhibition of NF-κB activation using TAK1 or LUBAC inhibitors resensitized LSCC tumors to cisplatin, suggesting a future avenue for LSCC patient treatment. [J Exp Med] Full Article Researchers observed that anterior gradient 2 (AGR2) expression was significantly suppressed by proteasome inhibitor MG132/bortezomib at mRNA and protein levels in lung cancer cells. MG132-mediated repression of AGR2 transcription was independent of ROS generation and ER stress induction, but partially resulted from the downregulated E2F1. [Oncogene] Full Article Scientists demonstrated that expressing type III TGF-β receptor (TβRIII)-super shedding (SS) in lung cancer cell models induced epithelial-to-mesenchymal (EMT) transition and that these TβRIII-SS (EMT) cells were less migratory, invasive and adhesive and more resistant to gemcitabine. [Oncogene] Abstract High CO2 levels, ranging from 5% to 15%, protected lung cancer cells from anticancer agents, such as cisplatin, carboplatin and etoposide, by suppressing apoptosis. In contrast, high CO2 levels did not affect cisplatin-mediated DNA damage responses or the expression of Bcl-2 family proteins. [Free Radic Biol Med] Abstract | Graphical Abstract Although pyrimethamine (Pyr) and methotrexate could inhibit the proliferation of lung cancer cells by targeting dihydrofolate reductase (DHFR), only Pyr could inhibit the epithelial-mesenchymal transition, metastasis and invasion of lung cancer cells. [Mol Cancer Ther] Abstract Subscribe to one of our other 19 science newsletters such as Cancer Stem Cell News & Human Immunology News. | |
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REVIEWSSafety and Tolerability of Anaplastic Lymphoma Kinase Inhibitors in Non-Small-Cell Lung Cancer The authors provide a comprehensive state-of-the-art review about the pharmacodynamics, pharmacokinetics, safety, and tolerability profiles of currently available and promising under-development anaplastic lymphoma kinase tyrosine kinase inhibitors. [Drug Saf] Abstract Visit our reviews page to see a complete list of reviews in the pulmonary cell research field. | |
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INDUSTRY NEWSLUNGevity has issued a Request for Applications for translational research for Career Development Awards that will be granted in 2019. Projects that will be funded in 2019 are expected to have a direct impact on the early detection of lung cancer and/or individualized lung cancer treatment, including through targeted therapy and immunotherapy. [LUNGevity Foundation] Press Release Verona Pharma plc announced top-line data from its three-day Phase II clinical pharmacology trial evaluating the effect of two different doses of nebulized ensifentrine when used on top of an inhaled long-acting muscarinic antagonist/long-acting beta2 agonist, tiotropium/olodaterol. [Verona Pharma plc] Press Release Bridge Biotherapeutics Inc. announced that the FDA has granted an orphan drug designation to BBT-877, a drug candidate under development for IPF treatment. BBT-877, a potent best-in-class autotaxin (ATX) inhibitor deregulates ATX, the enzyme found to be engaging in inflammation and fibrosis by generating the lipid signaling molecule. [Bridge Biotherapeutics Inc.] Press Release Genentech, announced that the FDA has accepted the company’s supplemental Biologics License Application for Tecentriq® in combination with Abraxane® and carboplatin for the initial treatment of people with metastatic non-squamous non-small cell lung cancer who do not have EGFR or ALK genomic tumor aberrations. [Genentech, Inc.] Press Release Aradigm Announces Detailed Third Party Evaluation Results for Apulmiq (FDA)/Linhaliq (EMA) Aradigm Corporation announced specific, detailed results of an independent third party evaluation of the Phase III clinical trial results for Apulmiq. [Aradigm Corporation] Press Release | |
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POLICY NEWSHow UK Scientists Are Planning for a Chaotic No-Deal Brexit British scientists are ramping up preparations for a ‘no deal’ Brexit on 29 March — a situation that would instantly affect travel, data collection, clinical trials and crucial laboratory supplies. [Nature News] Editorial German Institutions and Wiley Reach Open-Access Publishing Deal Ater nearly three years of contract negotiations, a consortium of nearly 700 German libraries, research institutes, and universities called Project DEAL has forged an agreement with the scholarly publisher Wiley that moves the publishing industry towards more open access. [The Scientist] Editorial
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EVENTSNEW Gordon Research Seminar: New Views of Organogenesis and Tumorigenesis: From Single Molecules to Therapeutics Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Scholar – Lung Repair & Regeneration (University of California San Francisco) NEW Postdoctoral Position – Lung Cancer (Albert Einstein College of Medicine of Yeshiva University) NEW Postdoctoral Fellow – Respiratory Research (Royal College of Surgeons Ireland) Tenure Track Group Leader – Lung Epidemiology (Helmholtz-Center Munchen) Tenure Track Investigator – Lung Cancer (Northwestern University) Associate/Full Professor – Lung Biology & Medicine (University of California, Davis) Postdoctoral Position – Asthma Epigenetics & Genomics (La Jolla Institute for Allergy & Immunology) Associate Professor – Oncology (University of California, Davis) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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