Cord Blood News Volume 11.19 | May 23 2019

TOP STORY

In Utero Transplantation of Expanded Autologous Amniotic Fluid Stem Cells Results in Long‐Term Hematopoietic Engraftment

The authors demonstrated that amniotic fluid stem cells have hematopoietic characteristics and, thanks to their fetal origin, favorable proliferation kinetics in vitro and in vivo, which were maintained when the cells were expanded. [Stem Cells] Abstract

(Ranked by impact factor of the journal)

Potency Analysis of Mesenchymal Stromal Cells Using a Phospho‐STAT Matrix Loop Analytical Approach

Researchers compared the short‐term phosphorylation status of STAT1, STAT3, STAT4, STAT5 and STAT6 on MSCs derived from human bone marrow, adipose tissue and umbilical cord using phosflow technology. [Stem Cells] Abstract

Fucosylated Umbilical Cord Blood Hematopoietic Stem Cell Expansion on Selectin‐Coated Scaffolds

The characteristics of cultured fucosylated and nonfucosylated cells on a two‐dimensional culture system, poly l‐lactic acid, and a selectin‐coated scaffold were evaluated by flow cytometry, 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide assay, colony‐forming unit assay, and CXCR4 expression at the messenger RNA and protein levels. [J Cell Physiol] Abstract

Microvesicles Derived from Human Wharton’s Jelly Mesenchymal Stem Cells Ameliorate Acute Lung Injury Partly Mediated by Hepatocyte Growth Factor

Treatment with MSC-microvesicles (MVs) significantly inhibited bleomycin-induced apoptosis and fibrosis in lung tissues and PI3K/AKT/mTOR activation, which was reversed by hepatocyte growth factor mRNA deficient MVs. [Int J Biochem Cell Biol] Abstract

Comparison of Cord Blood CD34⁺ Stem Cell Expansion in Coculture with Mesenchymal Stem Cells Overexpressing SDF‐1 and Soluble/Membrane Isoforms of SCF

MSCs and CD34⁺ hematopoietic stem cells were isolated from umbilical cord blood (UCB) mononuclear cells. UCB MSCs were nucleofected with one or more of soluble isoform of stem cell factor (sSCF), membrane isoform of SCF, and SDF‐1 expression vectors. [J Cell Biochem] Abstract

Biochemical and Clinical Response after Umbilical Cord Blood Transplant in a Boy with Early Childhood‐Onset Beta‐Mannosidosis

Investigators report two‐year outcomes following the first umbilical cord blood transplant in a four‐year‐old boy with early childhood‐onset disease. [Mol Genet Genomic Med] Full Article

Serological and Molecular Screening of Umbilical Cord Blood for Toxoplasma gondii Infection

Scientists studied the prevalence of toxoplasmosis in umbilical cord blood and assessed the sensitivity of ELISA and PCR for Toxoplasma infection screening. [Transpl Infect Dis] Abstract

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Tissue Engineering Strategies Combining Molecular Targets against Inflammation and Fibrosis, and Umbilical Cord Blood Stem Cells to Improve Hampered Muscle and Skin Regeneration following Cleft Repair

The authors outline a novel molecular and cellular strategy to improve musculature and skin regeneration and to reduce scar formation following cleft repair. [Med Res Rev] Full Article

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Be The Match BioTherapies^® Announces Strategic Collaboration with Kiadis Pharma to Accelerate Patient Access to Haploidentical Stem Cell Therapies

Be The Match BioTherapies^® and Kiadis Pharma N.V. announced a strategic collaboration to support clinical evaluation of an innovative cell therapy product with potential to make haploidentical hematopoietic stem cell transplantations safer and more effective for patients. [Be The Match BioTherapies^®] Press Release

ElevateBio Announces that AlloVir Joins Its Portfolio of Highly Innovative Cell and Gene Therapy Companies

ElevateBio announced that AlloVir has joined its growing portfolio of companies. AlloVir is built on an innovative technology platform developed by researchers at Baylor College of Medicine’s Center for Cell and Gene Therapy. [ElevateBio] Press Release

Brazilian Scientists Strive to Turn Politicians Into Allies

Brazil’s scientists are fighting back against President Jair Bolsonaro’s plans to slash funding for research and education programs. Researchers have joined with members of Brazil’s legislature, the National Congress, to highlight the strategic role that science, technology, and education play in the country’s economic and social development. [Nature News] Editorial

How European Scientists Will Spend €100 Billion

Politicians don’t win prizes for speed, but the European Union’s parliament and the leaders of its member states made record time this year when they hammered out an agreement that could supply researchers in Europe with more than €100 billion (US$113 billion) over seven years. [Nature News] Editorial

NEW Stem Cells UK 2019
October 1, 2019
London, United Kingdom

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NEW PhD Student – Hematopoietic Stem Cell Biology/Immunology (Medizinische Fakultät Carl Gustav Carus)

NEW Research Assistant I – Lymphoma/Myeloma (MD Anderson Cancer Center)

NEW Postdoctoral Position – Epigenetic Regulation of Hematopoietic Stem Cells (Karolinska Institutet)

Postdoctoral Scientist – Hematopoietic Stem Cell Research (DKFZ / HI-STEM)

Postdoctoral Researcher – Normal and Malignant Hematopoiesis (Karolinska Institutet)

Postdoctoral Position – Stem Cell Transplant Immunology (University of Illinois at Chicago)

Research Technician – Leukemia (VIB)

Postdoctoral Fellows – Hematological Malignancies and Cancer Immunology (Fox Chase Cancer Center)

Faculty Positions – Cancer Research (Shenzhen University)

Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.

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