Cord Blood News Volume 11.32 | Aug 22 2019

TOP STORY

Decitabine Assists Umbilical Cord-Derived Mesenchymal Stem Cells in Improving Glucose Homeostasis by Modulating Macrophage Polarization in Type 2 Diabetic Mice

Researchers used decitabine, which is involved in the regulation of macrophage polarization, to test whether MSCs combined with decitabine could prolong and enhance the anti-diabetic effect in type 2 diabetes mice. [Stem Cell Res Ther] Full Article | Graphical Abstract

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Therapeutic Effects of Human Umbilical Cord Mesenchymal Stem Cell-Derived Microvesicles on Premature Ovarian Insufficiency in Mice

The effect of human umbilical cord MSC-derived microvesicles on the restoration of ovarian function in a chemotherapy-induced premature ovarian insufficiency mouse model was investigated. [Stem Cell Res Ther] Full Article

Low-Dose Decitabine Priming with Intermediate-Dose Cytarabine followed by Umbilical Cord Blood Infusion as Consolidation Therapy for Elderly Patients with Acute Myeloid Leukemia: A Phase II Single-Arm Study

In this prospective single arm study, the authors evaluated the efficacy and safety of a novel consolidation therapy with low-dose decitabine priming with intermediate-dose cytarabine followed by umbilical cord blood infusion in elderly patients with acute myeloid leukemia. [BMC Cancer] Full Article

Exosomal miR‐1246 Derived from Human Umbilical Cord Blood Mesenchymal Stem Cells Attenuates Hepatic Ischemia Reperfusion Injury by Modulating T Helper 17/Regulatory T Balance

Scientists explored the mechanism by which human umbilical cord blood MSC‐derived exosomes exerted a protective effect in hepatic ischemia/reperfusion injury. [IUBMB Life] Abstract

Comparison between Intermittent and Continuous Leukapheresis Protocols for Autologous Hematopoietic Stem Cell Collections in Children

Investigators prospectively collected clinical, laboratory, and technical collection data from hematopoietic stem cell collection procedures performed with the Spectra Optia apheresis system utilizing the continuous mononuclear collection protocol protocol. Data were compared to retrospectively collected data utilizing the mononuclear cell protocol. [J Clin Apher] Abstract

DNA Methylation Microarray Uncovers a Permissive Methylome for Cardiomyocyte Differentiation in Human Mesenchymal Stem Cells

Scientists used the Agilent 180 K human DNA methylation microarray on Wharton’s jelly (WJ)-MSCs, 5′azacytidine treated WJ-MSCs and human cardiac tissue to analyze differential DNA methylation profiles which were then validated by bisulfite sequencing PCR. [Genomics] Abstract

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Engineering Universal Cells that Evade Immune Detection

The prospect of transplanting cells and tissues without the risk of immune rejection or the need for powerful immunosuppressive drugs is the ‘holy grail’ of transplantation medicine. Now, with the advent of pluripotent stem cells, CRISPR-Cas9 and other gene-editing technologies, the race to create ‘off-the-shelf’ donor cells that are invisible to the immune system has started. [Nat Rev Immunol] Abstract

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Phio Pharmaceuticals and Helmholtz Zentrum München to Collaborate on Novel Targets for the Use of Self-Delivering RNAi In T Cell and NK Cell Adoptive Cell Therapy Therapeutics

Phio Pharmaceuticals Corp. announced that is has entered into a research collaboration with the Helmholtz Zentrum München. The agreement covers the design and development of new targets based on Phio Pharmaceuticals’ proprietary self-delivering RNAi platform for use in cancer immunotherapies. [Phio Pharmaceuticals Corp.] Press Release

NKMax America Doses First Subject in Phase I Trial of SNK in Patients with Refractory Cancer

NKMax America announced that it has dosed the first subject in study SNK01-US01, a Phase I clinical trial evaluating SNK, an ex vivo expanded autologous natural killer cell therapeutic, in patients with pathologically confirmed cancer refractory to conventional therapy. [NKMax America (PR Newswire Association LLC.)] Press Release

More Than 700 German Research Institutions Strike Open-Access Deal with Springer Nature

A consortium of more than 700 German research institutions and libraries announced an agreement with publisher Springer Nature to make it simpler for authors to publish their papers open access. The agreement is the largest national open-access deal to date, but it doesn’t allow authors to publish open access in Nature or its sister journals. [ScienceInsider] Editorial

As Brexit Nears, Britain’s Drugs, Devices and Pricing Regulators Seek the Exit

Firm details on exactly how the UK will regulate new medicines is still to be decided after it leaves the EU later this year (caveats on timing abound), but we now know that the regulator won’t be run by Dr. Ian Hudson, who is stepping down after six years in charge. [FierceBiotech] Editorial

Brazil’s Budget Cuts Threaten More Than 80,000 Science Scholarships

Brazil’s main science-funding agency will have to suspend more than 80,000 scholarships to postdoctoral researchers and graduate and undergraduate students starting in September unless it receives additional cash from the government. [Nature News] Editorial

NEW Precision Health: Molecular Basis, Technology and Digital Health
November 13-16, 2019
Heidelberg, Germany

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NEW Postdoctoral Studies – Normal and Aberrant Hematopoiesis (Karolinska Institutet)

NEW Postdoctoral Scholarship – Human Erythropoiesis (Lund University)

Scientific Communications Coordinator (STEMCELL Technologies Inc.)

Postdoctoral Scholarship – Computational Genomics and Bioinformatics (Lund University)

Postdoctoral Scholar – Gene and Cell Therapy (Stanford University)

Associate Professor – Pediatrics (Pennsylvania State University)

Early Stage Researchers – Hematopoiesis (Multiple Locations)

Faculty Positions – Cancer and Blood Diseases (The Research Institute at Nationwide Children’s Hospital)

PhD Positions – Age-Related Changes in Hematopoiesis (University of Milano-Bicocca)

Postdoctoral Position – Bone/Stem Cell Biology (University of California, San Francisco)

Tenure-Track Positions – Stem Cell Biology and Regenerative Medicine (Icahn School of Medicine at Mount Sinai)

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