Cord Blood News Volume 12.03 | Jan 30 2020

TOP STORY

Schnurri-3 Regulates BMP9-Induced Osteogenic Differentiation and Angiogenesis of Human Amniotic Mesenchymal Stem Cells through Runx2 and VEGF

Scientists conducted a comprehensive study to identify the effect of Schnurri-3 on bone morphogenetic protein 9 (BMP9)-induced osteogenic differentiation and angiogenesis in human amniotic MSCs and analyzed the responsible signaling pathway. [Cell Death Dis] Full Article

(Ranked by impact factor of the journal)

Exosomes Derived from Human Umbilical Cord Mesenchymal Stem Cells Ameliorate IL-6-Induced Acute Liver Injury through miR-455-3p

Researchers stimulated human umbilical cord MSCs (hUC-MSCs) with interleukin-6 (IL-6), and the hUC-MSC-derived exosomes were deeply sequenced. The miRNAs in the exosomes that had potential to suppress IL-6-associated signaling pathway were screened, and the role of one of the most possible miRNAs was tested in the mouse model of inflammatory liver injury. [Stem Cell Res Ther] Full Article

Umbilical Cord-Matrix Stem Cells Induce the Functional Restoration of Vascular Endothelial Cells and Enhance Skin Wound Healing in Diabetic Mice via the Polarized Macrophages

Umbilical cord-matrix stem cells or conditioned medium were injected into the cutaneous wounds of streptozotocin-induced diabetic mice. The effects of this treatment on macrophages and diabetic vascular endothelial cells were investigated in vivo and in vitro. [Stem Cell Res Ther] Full Article | Graphical Abstract

The Effects of Inhibin B in the Chemotherapy Drug-Induced Premature Ovarian Insufficiency Mice and hPMSCs Treatment

Scientists explored the effects of human placenta MSC (hPMSC) treatment on chemotherapy drug-induced premature ovarian insufficiency (POI) mice. Cyclophosphamide and busulfan or cyclophosphamide induced POI mice were used and hPMSCs were injected through the tail vein. [Reprod Sci] Abstract

Human Umbilical Cord Blood-Derived Mesenchymal Stem Cell Implantation for Osteoarthritis of the Knee

The authors investigated the clinical outcomes after human umbilical cord blood-derived MSC implantation for medial compartment osteoarthritis of the knee. [Arch Orthop Trauma Surg] Abstract

Umbilical Cord-Derived Mesenchymal Stem Cells for Treating Osteoarthritis of the Knee: A Single-Arm, Open-Label Study

Investigators conducted an open-label trial of human umbilical cord-derived MSCs and hyaluronic acid for treating knee osteoarthritis. [Eur J Orthop Surg Traumatol] Abstract

Subscribe to one of our other 19 science newsletters such as Hematopoiesis News & Cell Therapy News.

Perspectives for Future Use of Extracellular Vesicles from Umbilical Cord- and Adipose Tissue-Derived Mesenchymal Stem/Stromal Cells in Regenerative Therapies—Synthetic Review

The authors focus on pro-regenerative properties of extracellular vesicles derived from adipose derived stem cells and umbilical cord Wharton’s jelly-MSCs. They provide a synthetic summary of research conducted in vitro and in vivo by employing animal models and within initial clinical trials focusing on neurological, cardiovascular, liver, kidney, and skin diseases. [Int J Mol Sci] Abstract | Download Full Article

Visit our reviews page to see a complete list of reviews in the cord blood research field.

Celularity Announces FDA Clearance of Landmark IND for CYNK-001, an Allogeneic, Off-the-Shelf Cryopreserved NK Cell Therapy

Celularity, Inc. announced the FDA has cleared the company’s Investigational New Drug (IND) Application for CYNK-001 in patients with glioblastoma multiforme (GBM). The clinical investigation of CYNK-001 in patients with GBM is expected to be the first clinical trial in the US to investigate intratumoral administration of an allogeneic NK cell therapy. [Celularity, Inc. (BusinessWire, Inc.)] Press Release

MicroCures Advances Burn Wound Healing Program under Cooperative Research and Development Agreement (CRADA) with the US Army Institute of Surgical Research (USAISR)

MicroCures announced the advancement of its ongoing collaborative research project with the USAISR in the area of burn wound healing. [MicroCures] Press Release

Most Innovative Cancer Drugs Take Too Long to Reach Patients in the UK

Despite giddy advances in treating cancer, a new analysis finds needed medicines have been reaching patients in the UK more slowly, and that both drug makers and government agencies are to blame. [STAT News] Editorial

NIH’s New Cluster Hiring Program Aims to Help Schools Attract Diverse Faculty

The National Institutes of Health (NIH) is hoping universities will use a controversial, and largely untested, method of hiring junior faculty members to improve the diversity of the US biomedical research workforce. [ScienceInsider] Editorial

NEW First International STEMNET Meeting
May 6-8, 2020
Padua, Italy

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Fellow Positions – Epigenetics, 3D Bioprinting, Hematopoietic Stem Cell Biology, Bioengineering, and Blood Cancers (Childrens Hospital & Ohio State University)

Scientist – Hematopoietic Stem and Progenitor Cell Biology (STEMCELL Technologies Inc.)

Postdoctoral Position – Blood Engineering (Karolinska Institutet)

Research Fellow – Hematopoietic Diseases (University College London)

Assistant or Associate Professor – Hematopoietic Cell Transplant Program (Fred Hutchinson Cancer Research Center)

Senior Research Scientist – Stem Cell Biology and Disease Modeling (Tata Institute for Genetics and Society)

Postdoctoral and Scientist Position – Developmental Hematopoiesis and Gene Regulation (Icahn School of Medicine at Mount Sinai)

Research Assistant Professor – Hematology, Oncology and Blood & Marrow Transplantation (University of Iowa)

Postdoctoral Fellow – Cancer Immunotherapy/CAR T Cell Development (City of Hope)

Research Fellow – Stem Cell Biology & Engineering (New York Blood Center)

Postdoctoral Fellowship – Hematopoiesis, Leukemia, and Bone Marrow Failure Syndromes (The University of Texas Southwestern Medical Center)

Postdoctoral Fellow – Erythropoiesis (Mount Sinai School of Medicine)

Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.

Have we missed an important article or publication in Cord Blood News? Click here to submit!

Comments or suggestions? Submit your feedback here.