Cord Blood News Volume 12.10 | Mar 19 2020

TOP STORY

Umbilical Cord-Derived CD362⁺ Mesenchymal Stromal Cells for E. coli Pneumonia: Impact of Dose Regimen, Passage, Cryopreservation, and Antibiotic Therapy

CD362⁺ umbilical cord-human MSCs were as effective as heterogonous MSCs in reducing E. coli-induced acute lung injury, improving oxygenation, decreasing bacterial load, reducing histologic injury, and ameliorating inflammatory marker levels. [Stem Cell Res Ther] Full Article

(Ranked by impact factor of the journal)

Microvesicles Derived from Human Wharton’s Jelly Mesenchymal Stem Cells Enhance Autophagy and Ameliorate Acute Lung Injury via Delivery of miR-100

MSC-microvesicle treatment attenuated bleomycin (BLM)-induced apoptosis and inflammation in BLM-treated L2 cells and ameliorated BLM-induced lung apoptosis, inflammation, and fibrosis in BLM-induced acute lung injury rats. [Stem Cell Res Ther] Full Article

Prospective Evaluation of Alternative Donor from Unrelated Donor and Cord Blood in Adult Acute Leukemia and Myelodysplastic Syndrome

A prospectively registered observational study was conducted to assess the significance of allogeneic hematopoietic stem cell transplantation from highly HLA-matched unrelated donors and cord blood on outcomes in adult acute leukemia and myelodysplastic syndrome. [Bone Marrow Transplant] Abstract

Energy Metabolism Analysis of Three Different Mesenchymal Stem Cell Populations of Umbilical Cord under Normal and Pathologic Conditions

Perivascular region-MSCs showed the highest mitochondrial activity. Cord lining-MSCs were the least affected by oxygen and glucose deprivation/R condition, suggesting their robust survival in ischemic environment. [Stem Cell Rev Rep] Full Article

Intravenous Human Umbilical Cord-Derived Mesenchymal Stromal Cell Administration in Models of Moderate and Severe Intracerebral Hemorrhage

Magnetic resonance imaging showed that animals treated with human umbilical cord Wharton’s jelly-derived MSCs after moderate intracerebral hemorrhage (ICH) had smaller residual hematoma volumes than vehicle-treated rats, whereas the cell therapy failed to decrease the hematoma volume in animals with a severe ICH. [Stem Cells Dev] Abstract

Inhibition of Ice Recrystallization during Cryopreservation of Cord Blood Grafts Improves Platelet Engraftment

The authors showed that supplementation of dimethyl sulfoxide with ice recrystallization inhibitor (IRI)2 had several beneficial effects. Specifically, higher levels of human platelets were observed in the peripheral blood upon transplant of cord blood units preserved with the IRIs. [Transfusion] Abstract

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Hematopoietic Stem Cell Transplantation for Multiple Sclerosis: Current Status

Prospective randomized and uncontrolled trials and retrospective case series were reviewed to examine the safety and efficacy of the procedure. [BioDrugs] Abstract

Visit our reviews page to see a complete list of reviews in the cord blood research field.

Cellenkos Inc. Focuses on the Development of Cell-Therapy for Treatment of COVID-19 Mediated Acute Respiratory Distress Syndrome (CoV-ARDS)

Cellenkos, Inc. announced that the company has submitted a clinical development proposal to the Biomedical Advanced Research and Development Authority to start a Phase I/II clinical trial with CK0802 for treatment of CoV-ARDS. CK0802, is a novel allogenic cell therapy, consisting of T-regulatory cells derived from clinical-grade umbilical cord blood units, developed from Cellenkos’ proprietary manufacturing platform, that overcomes immune dysfunction by resolving chronic inflammation. [Cellenkos, Inc. (PR Newswire Association LLC)] Press Release

European Commission Approves Venclyxto plus Gazyvaro for Adults with Previously Untreated Chronic Lymphocytic Leukemia

Roche announced that the European Commission has approved Venclyxto^® in combination with Gazyvaro^® for the treatment of adult patients with previously untreated chronic lymphocytic leukemia. [F. Hoffmann-La Roche Ltd] Press Release

Respirators, Quarantines, and Worst-Case Scenarios: Lab Animal Facilities Grapple with the Pandemic

Many universities are currently grappling with the best way to care for the millions of mice, monkeys, and other research animals they care for across the country, in addition to protecting the health of their own employees. [ScienceInsider] Editorial

Journals, Peer Reviewers Cope with Surge in COVID-19 Publications

Academic journals have already taken steps to accelerate the flow of peer-reviewed information by expediting editorial and peer review for coronavirus-related manuscripts and granting them open-access status upon publication. [The Scientist] Editorial

Near-Lockdown in the Bay Area ‘Ratchets Up’ Challenges for Local Biotechs and Labs

Seven counties in the San Francisco Bay Area went into near-lockdown — ushering in a new reality for biopharma companies and biomedical labs. The “shelter in place” order offers significant leeway for medical research. [STAT News] Editorial

In light of COVID-19, many conferences are being cancelled or postponed. As such:

We are suspending new event postings in our newsletters and on Twitter.
We will strive to keep our current event listings updated with event status.
We encourage you to visit event sites directly for updates.

Visit our events page to see a complete list of events in the community.

NEW Group Leader – Pediatric Leukemia (German Cancer Research Center in the Helmholtz Association)

Postdoctoral Researcher – Hematologic Malignancies (Northwestern University)

Postdoctoral Position – Hematopoietic Stem Cell Biology (Columbia University Medical Center)

Postdoctoral Positions – Cancer Research (Moores Cancer Center, UC San Diego)

Team Leader – Clonal Evolution in Leukemias (Institute of Cancer Research)

Postdoctoral Researcher – Leukemia (Universitätsklinikum Carl Gustav Carus Dresden)

Postdoctoral Scientist – Stem Cell Biology (Cancer Research UK Manchester Institute)

Research Technician – Graft versus Host Disease (Fred Hutchinson Cancer Research Center)

Laboratory Director – Cord Blood Processing (PerkinElmer)

Tenure-Track/Tenured Faculty Positions – Biomedical Science (Southern University of Science and Technology)

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