Dermal Cell News Volume 5.32 | Sep 23 2019

TOP STORY

Dermal Adipose Tissue Has High Plasticity and Undergoes Reversible Dedifferentiation in Mice

Scientists isolated dermal adipocytes and characterized dermal fat at the cellular and molecular level. Together with its dynamic responses to external stimuli, they established that dermal adipocytes were a distinct class of white adipocytes with high plasticity. [J Clin Invest] Abstract | Full Article

(Ranked by impact factor of the journal)

DERMAL STEM CELLS & TISSUE REGENERATION

Endothelin‐1 and α‐Melanocortin Have Redundant Effects on Global Genome Repair in UV‐Irradiated Human Melanocytes Despite Distinct Signaling Pathways

The keratinocyte‐derived endothelin‐1 and α‐melanocyte stimulating hormone regulated human melanocyte function, proliferation and survival, and enhanced repair of ultraviolet radiation (UV)‐induced DNA photoproducts by binding to the G_q‐ and G_i‐protein coupled endothelin B receptor, and the G_s‐protein coupled melanocortin 1 receptor, respectively. [Pigment Cell Melanoma Res] Abstract

Organogermanium Suppresses Cell Death Due to Oxidative Stress in Normal Human Dermal Fibroblasts

Researchers attempted to visualize the incorporation of germanium into normal human dermal fibroblasts using isotope microscopy. [Sci Rep] Full Article

¹⁸F-Labeled Cyclized α-Melanocyte-Stimulating Hormone Derivatives for Imaging Human Melanoma Xenograft with Positron Emission Tomography

Investigators evaluated [¹⁸F]CCZ01064 as well as a novel dual-ammoniomethyl-trifluoroborate derivative, [¹⁸F]CCZ01096, for targeting human melanoma xenograft using μPET imaging. [Sci Rep] Full Article

Impact of Ultraviolet Radiation on Dermal and Epidermal DNA Damage in a Human Pigmented Bilayered Skin Substitute

Tissue‐engineered skin substitutes were cultured using different concentrations of melanocytes and pigmentation was evaluated in vitro and after grafting onto an athymic mouse excisional model. [J Tissue Eng Regen Med] Abstract

SKIN CANCERS & DISORDERS

The Zinc-Finger AN1-Type Domain 2a Gene Acts as a Regulator of Cell Survival in Human Melanoma: Role of E3-Ligase cIAP2

Scientists showed that bortezomib and next-generation proteasome inhibitors ixazomib and carfilzomib markedly induce zinc-finger AN1-type domain-2a gene (AIRAP) expression in human melanoma at concentrations comparable to plasma-levels in treated patients. [Mol Cancer Res] Abstract

Local Anesthetics Counteract Cell Proliferation and Migration of Human Triple‐Negative Breast Cancer and Melanoma Cells

Two different human cancer cell lines, MDA‐MB‐231, triple‐negative breast cancer, and A375, melanoma, were used. By means of Western blotting and immunofluorescence and terminal deoxynucleotidyl transferase dUTP nick end labeling analyses, the signal transduction pathways activated by the anesthetics, such as ropivacaine and levobupivacaine, were analyzed. [J Cell Physiol] Abstract

PTEN, A Target of MicroRNA-374b, Contributes to the Radiosensitivity of Canine Oral Melanoma Cells

Investigators developed the radioresistant canine oral malignant melanoma cell line, KMeC/R. They found that the expression level of phosphatase and tensin homolog (PTEN) of KMeC/R cells was significantly downregulated compared with KMeC cells. [Int J Mol Sci] Full Article

LncRNA FOXD3-AS1 Promotes Proliferation, Invasion and Migration of Cutaneous Malignant Melanoma via Regulating miR-325/MAP3K2

FOXD3-AS1 levels in 47 pairs of melanoma samples were detected. The authors used qRT-PCR to detect FOXD3-AS1, miR-325 and MAP3K2 expression in different staging samples and cutaneous melanoma cell lines. [Biomed Pharmacother] Abstract

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Significance of BRAF Kinase Inhibitors for Melanoma Treatment: From Bench to Bedside

The authors focus on pre-clinical studies and early to Phase III clinical trials to discuss the development of combined therapy based on BRAF inhibitors for BRAF-mutant advanced melanoma, as well as mechanisms of resistance to BRAF inhibitors. [Cancers] Full Article

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Mallinckrodt Announces Positive Top-Line Results from Pivotal Phase III Clinical Trial of StrataGraft^® Regenerative Tissue in Patients with Deep Partial-Thickness Thermal Burns

Mallinckrodt plc announced positive top-line results from its pivotal Phase III clinical trial of its investigational StrataGraft^® regenerative tissue. [Mallinckrodt plc] Press Release

XBiotech Announces Granting of Canadian Patent for Treatment of Dermatological Pathologies

XBiotech Inc. announced that the Canadian Patent Office has granted XBiotech a patent covering the use of bermekimab in the treatment of inflammatory skin diseases. [XBiotech Inc.] Press Release

International Council of Dermatologists Introduces New Method of Determining Psoriasis Severity

To the benefit of millions of people living with uncontrolled psoriasis worldwide, a global consortium of more than 100 physician leaders in dermatology led by the International Psoriasis Council has developed a simplified method used to classify psoriasis severity and determine the appropriate course of treatment. [International Psoriasis Council (PR Newswire Association LLC.)] Press Release

Grad Student Unions Dealt Blow as Proposed New Rule Says Students Aren’t ‘Employees’

Graduate students are not “employees” with a right to unionize, according to a rule proposed by the National Labor Relations Board (NLRB), an agency that’s tasked with enforcing US labor laws. If implemented, the rule would undercut a recent wave of grad student unionization efforts at private US universities. [ScienceInsider] Editorial

Kashmir’s Communication Blackout Is a ‘Devastating Blow’ for Academics, Researchers Say

Six professors from India’s top science institutions have appealed to the government to lift the blockade of academic and research institutions in Indian-controlled Kashmir. The blockade has been a “devastating blow,” the six write in an open letter published September 18^th [ScienceInsider] Editorial

NEW Linking Cells, the Cytoskeleton and the Nucleus in Mechanobiology, Aging and Disease
June 7-12, 2020
West Dover, Vermont, United States

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NEW Scientific Officer – Human Skin and Lung Toxicology (Federal Institute for Risk Assessment)

NEW Postdoctoral Fellowship – Dermatology (Brigham and Women’s Hospital)

Postdoctoral Fellowship – Wound Healing and Tissue Regeneration (Memorial Sloan Kettering Cancer Center)

Faculty Positions – Cutaneous Oncology and Skin Cancer Research (Columbia University Medical Center)

Postdoctoral Researcher – Cancer Research (Champalimaud Foundation)

Postdoctoral Position – Cancer Immunology (Northwestern University Feinberg School of Medicine)

Faculty Position – Cancer Biology (Children’s Research Institute at UT Southwestern)

Faculty Position – Cancer Biology (Emory University)

Postdoctoral Research Fellow – Epithelial Growth in Development and Cancer (Fred Hutchinson Cancer Research Center)

Postdoctoral Research Scholar – Autoimmunity (University of California, Davis)

Research Lab Specialist – Tumor Microenvironment & Cell Behavior (University of Southern California)

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