Extracellular Matrix News 10.27 July 18, 2019 | |
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TOP STORYScientists identified metabolic enzymes involved in ECM remodeling that were upregulated during epithelial-mesenchymal transition and were highly expressed in patients with aggressive mesenchymal-like breast cancer. [Oncogene] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Researchers showed that fibroblast growth factor receptor 1 reduced N-cadherin-mediated cell migration. Both proteins were co-stabilized at cell-cell contacts through direct interaction. [Oncogene] Abstract RNA sequencing identified a fusion involving fibronectin 1 (FN1) and fibroblast growth factor receptor 2 (FGFR2) in the case of soft tissue chondroma and FISH confirmed recurrent involvement of both FGFR1 and FGFR2. [Mod Pathol] Abstract Investigators report on a novel approach suitable for local treatment of multiple myeloma based on hyaluronic acid (HA) hydrogels mimicking the physical properties of bone marrow. The HA hydrogels were complexed with heparin to achieve sustained presentation and controlled release of bone morphogenetic protein 6 (BMP-6). [Acta Biomater] Abstract | Graphical Abstract Laminin derived peptides, IKVAV and LRE, tethered to independent sites in hyaluronic acid matrices using Michael addition and strain-promoted azide-alkyne cycloaddition were sufficient to manipulate hyaluronic acid degradation, gelatinase expression and protease expression. [Biomacromolecules] Abstract Senescent endothelial cells resulted in pericyte loss and increased endothelial secretion of matrix metallopeptidase 9, which further contributed to retinal ganglion cell loss. Cytochrome P450 (CYP) 2J2 overexpression alleviated vascular senescence, pericyte loss, and matrix metallopeptidase 9 secretion. [FASEB J] Abstract Inhibition of the laminin-integrin α7 signaling axis resulted in a reduction in smooth muscle-alpha actin abundance and did not revert airway smooth muscle cells back to a proliferative phenotype. [Sci Rep] Full Article Syndecan-4 Regulates Extravillous Trophoblast Migration by Coordinating Protein Kinase C Activation First trimester extravillous trophoblast (EVT) line EVTs exhibited reduced migration and Matrigel-based invasion, both under basal conditions and following exposure to basic fibroblast growth factor and heparin-binding epidermal growth factor. [Sci Rep] Full Article Interleukin-17 and Matrix Metalloprotease-9 Expression in the Mycetoma Granuloma Surgical biopsies from 100 patients with confirmed mycetoma were obtained, and interleukin-17 and matrix metalloprotease-9 expression in the mycetoma granuloma were evaluated immunohistochemically. [PLoS Negl Trop Dis] Full Article Researchers examined the expression levels of forkhead box M1 (FOXM1) in clinical keloid tissue specimens and primary keloid fibroblasts (KFs). The results showed that FOXM1 levels were significantly increased in both keloid tissues and KFs. [Life Sci] Abstract Subscribe to one of our other 19 science newsletters such as Endothelial Cell News & Dermal Cell News. | |
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REVIEWSEstrogen Receptor-Mediated Targeting of the Extracellular Matrix Network in Cancer The authors critically survey the current knowledge on dynamic interactions among estrogen receptors and major ECM macromolecules and effectors, such as growth factor receptors, proteoglycans and matrix metalloproteinases, in respect to their key effects in cancer progression, cancer cell functional properties, epithelial-to-mesenchymal transition and epigenetics. [Semin Cancer Biol] Abstract Visit our reviews page to see a complete list of reviews in the extracellular matrix research field. | |
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INDUSTRY NEWSEngineering Faculty Member Receives Grants Totaling $1.5M for Bioprinting Ibrahim Tarik Ozbolat, Hartz Family Career Development Associate Professor of Engineering Science and Mechanics, has received four grants totaling about $1.5 million to explore ways to bioprint biological tissues like bone, lungs and other organs for use as models in a variety of studies. [Pennsylvania State University] Press Release | |
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POLICY NEWSThe Plan to Mine the World’s Research Papers Carl Malamud is on a crusade to liberate information locked up behind paywalls — and his campaigns have scored many victories. Now, the 60-year-old American technologist is turning his sights on a new objective: freeing paywalled scientific literature. And he thinks he has a legal way to do it. [Nature News] Editorial Virologists Escorted Out of Lab in Canada Canada’s national police force is investigating “possible policy breaches” after researchers were escorted from a lab at Canada’s National Microbiology Laboratory in Winnipeg, CBC News reported. Prominent virologist Xiangguo Qiu, her colleague and husband Keding Cheng, and an unknown number of her students from China were removed from the lab. [The Scientist] Editorial
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EVENTSNEW Keystone Symposia: Fibrosis and Tissue Repair: From Molecules and Mechanics to Therapeutic Approaches Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Researcher – Extracellular Matrix of Brain Vessels (Inserm) NEW Research Fellow – Lectin Biochemistry (University of Leeds) Scientist – Matrix Biology (STEMCELL Technologies Inc.) PhD Position – Extracellular Matrix & Skin Immunology (University of Freiburg) Postdoctoral Fellow – ECM Remodeling & Cancer Invasion Research (Luxembourg Institute of Health) Postdoctoral Fellow – Role of Collagen in Tissue Repair & Regeneration (University of Pennsylvania) Research Lab Specialist – Tumor Microenvironment & Cell Behavior (University of Southern California) Postdoctoral Position – Bioengineering Cell Fate & Morphogeneis in Organoids (KU Leuven) Postdoctoral Research Fellowships – Kidney Disease (Vanderbilt University Medical Center) Postdoctoral Fellowship – Renal Extracellular Matrix Research (Vanderbilt University Medical Center) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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