Extracellular Matrix News Volume 10.32 | Aug 22 2019

TOP STORY

Thermo-Responsive In-Situ Forming Hydrogel with Sol-Gel Irreversibility for Effective Methicillin-Resistant Staphylococcus aureus Infected Wound Healing

Scientists report a sprayable in-situ forming hydrogel composed of poly(N-isopropylacrylamide₁₆₆–co-n-butylacrylate₉) -poly(ethylene glycol)- poly(N-isopropylacrylamide₁₆₆–co-n-butylacrylate₉) copolymer and silver nanoparticles decorated reduced graphene oxide nanosheets in response to skin temperature. [ACS Nano] Abstract

(Ranked by impact factor of the journal)

Impaired Mitochondrial ATP Production Downregulates Wnt Signaling via ER Stress Induction

Investigators showed that sublethal concentrations of different compounds that decreased mitochondrial ATP production specifically downregulated Wnt/β-catenin signaling in vitro in colon cancer cells and in vivo in zebrafish reporter lines. [Cell Rep] Full Article | Graphical Abstract

The Dysfunction of BP180/Collagen XVII in Keratinocytes Promotes Melanoma Progression

The authors used a B16 mouse melanoma model to demonstrate that BP180 dysfunction in either skin or basal keratinocytes promoted myeloid derived suppressor cell influx into skin and tumor progression. [Oncogene] Abstract

Reverse Signaling by Semaphorin 4C Elicits SMAD1/5- and ID1/3-Dependent Invasive Reprogramming in Cancer Cells

Researchers identified a previously unknown function of transmembrane semaphorin 4C, acting in reverse mode, to elicit nonconventional TGF-β/BMP receptor activation and selective SMAD1/5 phosphorylation. [Sci Signal] Abstract

FXYD5 (Dysadherin) Upregulation Predicts Shorter Survival and Reveals Platinum Resistance in High-Grade Serous Ovarian Cancer Patients

Scientists demonstrated the possible involvement of FXYD domain-containing ion transport regulator 5 (FXYD5) and ECM-receptor interaction signal pathway in high-grade serous ovarian carcinoma survival and prognosis. [Br J Cancer] Abstract

CLIC4 Regulates Late Endosomal Trafficking and Matrix Degradation Activity of MMP14 at Focal Adhesions in RPE Cells

Investigators showed that membrane-type matrix metalloproteinase 14 (MMP14) was central to ECM degradation at the focal adhesions in human ARPE19 cells. The matrix degradative activity, but not the assembly, of the focal adhesion was regulated by chloride intracellular channel 4 (CLIC4). [Sci Rep] Full Article

A Biomimetic 3D Model of Hypoxia-Driven Cancer Progression

Hypoxia induced apoptosis and the selection of aggressive cells that acquired expression signatures associated with glycolysis, angiogenesis, cell-matrix interaction, epithelial to mesenchymal transition and metastatic ability. [Sci Rep] Full Article

Reconfigurable Open Microfluidics for Studying the Spatiotemporal Dynamics of Paracrine Signaling

Researchers described a reconfigurable microfluidic cell-culture system that facilitated the assembly of 3D tissue models by stacking layers that contained preconditioned microenvironments. [Nat Biomed Eng] Abstract

Doxycycline-Eluting Core-Shell Type Nanofiber-Covered Trachea Stent for Inhibition of Cellular Metalloproteinase and Its Related Fibrotic Stenosis

Real-time polymerase chain reaction in HT1080 cells and xenografted tissue models indicated that doxy-releasing nanofiber inhibited mRNA expression of metalloproteinases. [Pharmaceutics] Full Article

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Engineered Materials for Organoid Systems

The authors highlight how key cell-matrix interactions guiding stem-cell decisions can inform the design of biomaterials for the reproducible generation and control of organoid cultures. [Nat Rev Mater] Abstract

Dissecting and Rebuilding the Glioblastoma Microenvironment with Engineered Materials

Researchers summarize key features of the glioblastoma (GBM) microenvironment and discuss different strategies for the engineering of GBM tumor microenvironment models, including 2D and 3D models featuring chemical and mechanical gradients, interfaces and fluid flow. [Nat Rev Mater] Abstract

Visit our reviews page to see a complete list of reviews in the extracellular matrix research field.

Steadman Philippon Research Institute Receives NIH Award for Research

The National Institutes of Health (NIH) has awarded Steadman Philippon Research Institute (SPRI) a grant to study the correlation between pregnancy and wound healing. The principal investigator is Dr. Johnny Huard, Chief Scientific Officer and director of the Center for Regenerative Sports Medicine at SPRI. [Steadman Philippon Research Institute (GlobeNewswire, Inc.)] Press Release

Stem Cell Researcher Irving Weissman Awarded Albany Prize

Irving Weissman, MD, director of Stanford’s Institute for Stem Cell Biology and Regenerative Medicine, will receive the 2019 Albany Medical Center Prize in Medicine and Biomedical Research for his pioneering work in stem cell and cancer biology. [Stanford University] Press Release

More Than 700 German Research Institutions Strike Open-Access Deal with Springer Nature

A consortium of more than 700 German research institutions and libraries announced an agreement with publisher Springer Nature to make it simpler for authors to publish their papers open access. The agreement is the largest national open-access deal to date, but it doesn’t allow authors to publish open access in Nature or its sister journals. [ScienceInsider] Editorial

As Brexit Nears, Britain’s Drugs, Devices and Pricing Regulators Seek the Exit

Firm details on exactly how the UK will regulate new medicines is still to be decided after it leaves the EU later this year (caveats on timing abound), but we now know that the regulator won’t be run by Dr. Ian Hudson, who is stepping down after six years in charge. [FierceBiotech] Editorial

NEW Gordon Research Conference: Signal Transduction by Engineered Extracellular Matrices
July 19-24, 2020
Manchester, New Hampshire, United States

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Researcher – Molecular Mechanisms of Psychiatric Disorders (McLean Hospital)

NEW Postdoctoral Position – Receptor Biology (Scripps Research Institute)

NEW Postdoctoral Researcher – Circulating Extracellular RNAs in Reproductive Medicine (Columbia University)

NEW Postdoctoral Researcher – Intercellular Signaling Inflammation and Atherosclerosis (University of California, San Francisco)

Scientific Communications Coordinator (STEMCELL Technologies Inc.)

Scientist – Matrix Biology (STEMCELL Technologies Inc.)

Research Scientist – Intestinal Injury/Tissue Engineering (Nationwide Children’s Hospital)

Postdoctoral Fellowship – Bioengineering of 4D Scaffold Development (Nationwide Children’s Hospital)

Postdoctoral Researcher – Extracellular Matrix of Brain Vessels (Inserm)

Postdoctoral Fellow – ECM Remodeling & Cancer Invasion Research (Luxembourg Institute of Health)

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