Extracellular Matrix News Volume 10.41 | Oct 24 2019

TOP STORY

Transcytosis of Nanomedicine for Tumor Penetration

Scientists demonstrated that nanomedicine penetrated tumor lesions via an active trans-cell transportation process. They also demonstrated that enhanced tumor penetration promoted the therapeutic efficacy of a photodynamic therapeutic nanomedicine. [Nano Lett] Abstract

(Ranked by impact factor of the journal)

Stiffness-Switchable DNA-Based Constitutional Dynamic Network Hydrogels for Self-Healing and Matrix-Guided Controlled Chemical Processes

Researchers report on the design of a constitutional dynamic networks consisting of four toehold-modified constituents, two of which acted as bidentate units for chain-elongating, while the other two formed a tetradentate structure acting as a crosslinking unit. [Nat Commun] Full Article

Macrophage Metabolic Reprogramming Aggravates Aortic Dissection through the HIF1α-ADAM17 Pathway

Mechanistic studies revealed that macrophage hypoxia-inducible factor 1-alpha (HIF-1α) activation triggered vascular inflammation, ECM degradation and elastic plate breakage through increased a disintegrin and metallopeptidase domain 17, identified as a novel target gene of HIF-1α. [EBioMedicine] Full Article

Notch1-ADAM8 Positive Feed-Back Loop Regulates the Degradation of Chondrogenic Extracellular Matrix and Osteoarthritis Progression

The expression of ADAM8 was up-regulated in osteoarthritic chondrocytes. Knockdown of ADAM8 suppressed the osteoarthritis (OA) phenotype in the in vitro OA cell model. ADAM8 regulated OA progression through the activation of EGFR/ERK/NF-κB signaling pathway. [Cell Commun Signal] Full Article

A Disease Associated Mutation in Fibrillin-1 Differentially Regulates Integrin Mediated Cell Adhesion

The authors characterized the ability of RGD-binding integrins to mediate cell adhesion to fibrillin-1 or a disease-causing variant. They showed that seven of the eight RGD-binding integrins could mediate adhesion to fibrillin-1. [J Biol Chem] Abstract | Full Article

Computational/Experimental Evaluation of Liver Metastasis Post Hepatic Injury: Interactions with Macrophages and Transitional ECM

Investigators implemented a combined computational modeling and experimental approach to evaluate tumor growth following hepatic injury, focusing on ECM remodeling and interactions with local macrophages. Experiments were performed to determine ECM density and macrophage-associated cytokine levels. [Sci Rep] Full Article

TIMP-3 Deficiency Disrupts the Hepatocyte E-Cadherin/β-Catenin Complex and Induces Cell Death in Liver Ischemia and Reperfusion Injury

Researchers investigated the response of mice lacking TIMP-3 (TIMP-3^-/-) to hepatic IRI. They report that TIMP-3^-/- mice showed an enhanced inflammatory response, exacerbated organ damage, and further impaired liver function after IRI when compared to their wild-type littermates. [Liver Transpl] Abstract

The Interplay Between Cell-Cell and Cell-Matrix Forces Regulates Cell Migration Dynamics

Scientists developed an integrated experimental and analytical system to examine both the intercellular and extracellular traction forces acting on individual cells within an endothelial cell colony, as well as their roles in guiding cell migratory behaviors. [Biophys J] Abstract

A Novel Compound AB38b Attenuates Oxidative Stress and ECM Protein Accumulation in Kidneys of Diabetic Mice through Modulation of Keap1/Nrf2 Signaling

The underlying mechanisms of antioxidant effect of AB38b were explored in high glucose (HG)-treated mouse glomerular mesangial cells (GMCs). AB38b or resveratrol significantly alleviated oxidative stress and ECM accumulation in HG-treated GMCs. [Acta Pharmacol Sin] Abstract

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Metalloproteases: On the Watch in the Hematopoietic Niche

Metalloproteases and their inhibitors can impact the bioavailability of important local signals that instruct mammalian hematopoietic stem cell fate and function in the hematopoietic niche. Despite growing evidence, metalloprotease/tissue inhibitors of metalloproteases proteins are currently underappreciated as important modulators of hematopoiesis. [Trends Immunol] Full Article

Laminin 332 in Cancer: When the Extracellular Matrix Turns Signals from Cell Anchorage to Cell Movement

The authors summarize current knowledge regarding the established involvement of the laminin 332 γ2 chain in tumor invasiveness and discuss the role of its α3 and β3 subunits. [Semin Cancer Biol] Abstract

Visit our reviews page to see a complete list of reviews in the extracellular matrix research field.

Guilak Honored by Regenerative Medicine Organization

Farshid Guilak, PhD, a professor of orthopedic surgery, has been chosen to receive this year’s Senior Scientist Award from the Tissue Engineering and Regenerative Medicine Society. Guilak was selected for his significant contributions to the tissue engineering and regenerative medicine field. [Washington University School of Medicine in St. Louis] Press Release

Trump Names Seven to Revived Presidential Science Advisory Panel

Thirty-three months after taking office, President Donald Trump has chosen a group of business leaders to advise him on science and technology policy. [ScienceInsider] Editorial

UK Science Minister Says DARPA-Like Agency Is in the Works

The UK government is working to establish a “blue sky” funding agency similar to the US Defense Advanced Research Projects Agency, UK science minister Chris Skidmore told the Science and Technology Select Committee of Parliament’s House of Commons. [ScienceInsider] Editorial

NEW The Life of the Skeleton from Embryonic Development to Aging
February 2-7, 2020
Galveston, Texas, United States

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Researcher – Islet Biology, Stem Cells, and Regenerative Medicine (Geneva University)

NEW Faculty Position – Bone Biology and Regenerative Medicine (University of Michigan)

Scientist – Matrix Biology (STEMCELL Technologies Inc.)

Postdoctoral Fellowship – Metabolism, Signaling, and Epigenetics (University of California, Irvine)

PhD Candidate – Retinal Pigment Epithelium (RWTH Aachen University)

Research Associate – Protein Structural Biology (University of Manchester)

Postdoctoral Fellowship – Cell and Developmental Biology (Fred Hutchinson Cancer Research Center)

PhD Student – Receptor-Independent Signaling (University Hospital of Muenster)

Postdoctoral Fellow – Wound Healing (University of Pennsylvania)

Postdoctoral Researcher – Proteoglycans in Post-Traumatic Osteoarthritis (Drexel University)

Postdoctoral Researchers – Engineering Human Tissues (Columbia University)

Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.

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