Extracellular Matrix News Volume 10.42 | Oct 31 2019

TOP STORY

Extracellular Matrix Anisotropy Is Determined by TFAP2-Dependent Regulation of Cell Collisions

Combined experimentation and adaptation of Vicsek modeling demonstrated that the reorientation of cells relative to each other following collision played a role in generating matrix anisotropy. [Nat Mater] Abstract | Press Release

(Ranked by impact factor of the journal)

MT1-MMP Directs Force-Producing Proteolytic Contacts That Drive Tumor Cell Invasion

Actin polymerization was shown to produce pushing forces that repelled the confining matrix fibers, and required MT1-MMP matrix-degradative activity to widen the matrix pores and generate the invasive pathway. [Nat Commun] Full Article

Tankyrase Inhibition Preserves Osteoarthritic Cartilage by Coordinating Cartilage Matrix Anabolism via Effects on SOX9 PARylation

Investigators report the identification of tankyrase as a regulator of the cartilage anabolism axis based on systems-level factor analysis of mouse reference populations. Tankyrase inhibition drove the expression of a cartilage-signature matrisome and elicited a transcriptomic pattern that was inversely correlated with osteoarthritis progression. [Nat Commun] Full Article

Autologous Micrograft Accelerates Endogenous Wound Healing Response through ERK-Induced Cell Migration

Scientists demonstrated that autologous micrograft was enriched with a pool of wound healing-associated growth factors that could provide the starting signal for a faster endogenous wound healing response. [Cell Death Differ] Abstract

TET2-Interacting Long Noncoding RNA Promotes Active DNA Demethylation of the MMP-9 Promoter in Diabetic Wound Healing

The authors identified a Ten-eleven translocation 2 (TET2)-interacting long noncoding RNA (TETILA) that was upregulated in human diabetic skin tissues. TETILA regulated TET2 subcellular localization and enzymatic activity, indirectly activating matrix metalloproteinase-9 (MMP-9) promoter demethylation. [Cell Death Dis] Full Article

TGF-β1-Induced HSP47 Regulates Extracellular Matrix Accumulation via Smad2/3 Signaling Pathways in Nasal Fibroblasts

Scientists investigated the relationship between HSP47 expression and tissue remodeling in chronic rhinosinusitis. They also determined the underlying molecular mechanisms of TGF-β1-induced HSP47 and ECM production in nasal fibroblasts. [Sci Rep] Full Article

Increased Nasal Matrix Metalloproteinase-1 and -9 Expression in Smokers with Chronic Rhinosinusitis and Asthma

Researchers investigated matrix metalloproteinase expression in the nasal tissues of asthmatic patients with chronic rhinosinusitis and any association with cigarette smoking and osteitis. [Sci Rep] Full Article

Characterization of 3D Matrix Conditions for Cancer Cell Migration with Elasticity/Porosity-Independent Tunable Microfiber Gels

Scientists developed elasticity/porosity-tunable electrospun fibrous gel matrices composed of photocrosslinked gelatinous microfibers with well-regulated bonding. This system enabled independent modulation of microscopic fiber elasticity and matrix porosity. [Polymer J] Abstract

GBM-Targeted oHSV Armed with Matrix Metalloproteinase 9 Enhances Anti-Tumor Activity and Animal Survival

Researchers armed previously described EGFRvIII-targeted, neuronal microRNA-sensitive herpes simplex virus (oHSV) with a matrix metalloproteinase (MMP) 9 to improve intratumoral vector distribution. They showed that vector-expressed MMP9 enhanced therapeutic efficacy and long-term animal survival in a glioblastoma multiforme (GBM) xenograft model. [Mol Ther Oncolytics] Abstract | Full Article

Subscribe to one of our other 19 science newsletters such as Endothelial Cell News & Dermal Cell News.

Fibroblasts Fuel Immune Escape in the Tumor Microenvironment

The authors outline the current understanding of how cancer-associated fibroblasts fuel immune escape, as well as their potential clinical applications. [Trends Cancer] Abstract

Visit our reviews page to see a complete list of reviews in the extracellular matrix research field.

Kane Biotech Retains GR Consulting to Identify Potential Partnerships for Its Proprietary DispersinB^® Wound Care Hydrogel

Kane Biotech Inc. announced that they have retained GR Consulting to develop and implement the out-licensing strategy for their DispersinB^® wound care hydrogel for both the United States and European markets. [Kane Biotech, Inc.] Press Release

REANIMA: Toward a New Paradigm in Cardiac Regeneration

Research into new endogenous mechanisms of tissue regeneration is an innovative research avenue in cardiac regeneration. This is the central goal of the REANIMA project, a research program coordinated by Dr. Miguel Torres and supported by €8 million funding over five years, of which €1,380,000 will be directly managed at the Centro Nacional de Investigaciones Cardiovasculares. [Centro Nacional de Investigaciones Cardiovasculares (EurekAlert!)] Press Release

Increase in Academics Leaving the UK Since Brexit Vote

After the 2016 Brexit referendum, in which voters decided to have the UK leave the European Union (EU), the number of academics from EU countries leaving the United Kingdom for other university jobs increased by almost half, according to Times Higher Education. [The Scientist] Editorial

PhD-Turned-Policy Insider Takes Over World’s Largest Science Society

In January 2020, the 46-year-old structural biologist Sudip Parikh will become the new CEO of AAAS (which publishes Science) as the 171-year-old association pursues its mission to advance science and serve society. [ScienceInsider] Editorial

NEW Gordon Research Conferece: Tissue Stem Cell Regulation by Autonomous and Non-Autonomous Mechanisms
October 9-14, 2020
Hong Kong, China

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Research Fellowship – Cartilage Mechanobiology (KU Leuven)

NEW Postdoctoral Fellowship – Wound Healing and Tissue Regeneration (Memorial Sloan Kettering Cancer Center)

Scientist – Matrix Biology (STEMCELL Technologies Inc.)

Postdoctoral Researcher – Islet Biology, Stem Cells, and Regenerative Medicine (Geneva University)

Faculty Position – Bone Biology and Regenerative Medicine (University of Michigan)

Postdoctoral Fellowship – Metabolism, Signaling, and Epigenetics (University of California, Irvine)

PhD Candidate – Retinal Pigment Epithelium (RWTH Aachen University)

PhD Student – Receptor-Independent Signaling (University Hospital of Muenster)

Postdoctoral Fellow – Wound Healing (University of Pennsylvania)

Postdoctoral Researcher – Proteoglycans in Post-Traumatic Osteoarthritis (Drexel University)

Postdoctoral Researchers – Engineering Human Tissues (Columbia University)

Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.

Have we missed an important article or publication in Extracellular Matrix News? Click here to submit!

Comments or suggestions? Submit your feedback here.