Endothelial Cell News 4.17 May 13, 2019 | |
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TOP STORYScientists observed that brain endothelial cells in the aged mouse hippocampus expressed an inflammatory transcriptional profile with focal upregulation of vascular cell adhesion molecule 1 (VCAM1), a protein that facilitated vascular-immune cell interactions. [Nat Med] Abstract | Press Release | |
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PUBLICATIONS(Ranked by impact factor of the journal)Researchers observed a positive correlation between miR-103a-3p levels and angiotensin II (AngII)-induced renal dysfunction. miR-103a-3p suppressed expression of the sucrose non-fermentable-related serine/threonine-protein kinase SNRK in glomerular endothelial cells, and glomeruli of hypertensive nephropathy patients and AngII-infused mice showed reduced endothelial expression of SNRK. [Nat Commun] Full Article Sox17 Is Required for Endothelial Regeneration Following Inflammation-Induced Vascular Injury The authors identified Sox17 as a key regulator of endothelial cell regeneration using endothelial-specific deletion and overexpression of Sox17. Endotoxemia upregulated hypoxia inducible factor 1α, which in turn transcriptionally activated Sox17 expression. They observed that Sox17 increased endothelial cell proliferation via upregulation of Cyclin E1. [Nat Commun] Full Article Endothelial Cells in the Decidual Bed Are Potential Therapeutic Targets for Preterm Birth Prevention Under inflammatory conditions, IL-6 was readily expressed in decidual endothelial cells with signal transducer and activator of transcription 3 phosphorylation in perivascular stromal cells, which then regulated expression of anti-inflammatory IL-10. [Cell Rep] Full Article | Press Release | Graphical Abstract Endothelial Sash1 Is Required for Lung Maturation through Nitric Oxide Signaling Investigators showed that sterile alpha motif and SRC homology 3 domain containing protein 1 (Sash1) interacted with β-arrestin 1 downstream of the TLR4 pathway to activate Akt and endothelial nitric oxide synthase in microvascular endothelial cells. Generation of nitric oxide downstream of Sash1 in endothelial cells affected alveolar epithelial cells in a cGMP-dependent manner, inducing maturation of alveolar type 1 and 2 cells. [Cell Rep] Full Article | Graphical Abstract Endothelial cell (EC)-specific loss of discs large (Dlg1) produced a retinal vascular phenotype that closely matched the phenotype associated with reduced beta-catenin signaling, synergized with genetically-directed reductions in beta-catenin signaling components, and could be rescued by stabilizing beta-catenin in ECs. [eLife] Full Article Gain-of-function and loss-of-function experiments showed that miR-181a-5p and miR-181a-3p inhibited adhesion molecule expression in HUVECs and monocyte-endothelial cell interactions. miR-181a-5p and miR-181a-3p cooperatively receded endothelium inflammation compared with single miRNA strand. [Cell Death Dis] Full Article TRIM14 Promotes Endothelial Activation via Activating NF-κB Signaling Pathway Overexpression of TRIM14 significantly increased the expression of adhesion molecules such as VCAM-1, ICAM-1, E-Selectin and cytokines such as CCL2, IL-8, CXCL-1, TNF-α in activated endothelial cells, and by which it facilitated monocyte adhesion to endothelial cells. Conversely, knock-down of TRIM14 had the opposite effect on endothelial activation. [J Mol Cell Biol] Full Article Scientsts generated spheroids in which endogenous endothelial cells self-assembled to form highly organized endothelial networks among stromal cells. Using an optimized adipogenic differentiation medium to preserve endothelial cells, they obtained densely vascularized spheroids containing mature adipocytes with unilocular lipid vacuoles. [Sci Rep] Full Article Regulating Response and Leukocyte Adhesion of Human Endothelial Cell by Gradient Nanohole Substrate Nanohole pattern (HP) 2 gradient nanohole substrate (GHS) increased the attachment and proliferation of HUVECs. Also, gene expression of focal adhesion markers in HUVECs was significantly increased on HP2 GHS. In vitro tube formation assay showed the enhancement of tubular network formation of HUVECs after priming on GHS compared to Flat. [Sci Rep] Full Article miR-191 Inhibit Angiogenesis after Acute Ischemic Stroke Targeting VEZF1 Over-expression of miR-191 promoted apoptosis, but reduced the proliferation, migration, tube-forming and spheroid sprouting activity in HUVECs oxygen-glucose deprivation/reoxygenation model. Mechanically, vascular endothelial zinc finger 1 (VEZF1) was identified as the direct target of miR-191, and could be regulated by miR-191 at post-translational level. [Aging (Albany NY)] Full Article Subscribe to one of our other 19 science newsletters such as Extracellular Matrix News & Cell Therapy News. | |
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REVIEWSProteoglycan Signaling in Tumor Angiogenesis and Endothelial Cell Autophagy The newest trend in proteoglycan biology is the interplay between extracellular signaling and autophagy fueled by the close link between autophagy and angiogenesis. The authors summarize the most current evidence surrounding proteoglycan signaling in both of these biological processes featuring the well-known suspects, decorin and perlecan, as well as other up-and-coming neophytes in this evolving signaling web. [Semin Cancer Biol] Abstract Visit our reviews page to see a complete list of reviews in the endothelial cell research field. | |
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INDUSTRY NEWSFDA Approves EYLEA® (Aflibercept) Injection for Diabetic Retinopathy Regeneron Pharmaceuticals, Inc. announced that the FDA has approved EYLEA® injection to treat all stages of diabetic retinopathy (DR), and thereby reduce the risk of blindness. EYLEA is the only VEGF inhibitor approved with two dosing options for DR, allowing doctors to customize treatment to their patients’ needs. [Regeneron Pharmaceuticals, Inc.] Press Release Eli Lilly and Company announced that the FDA has approved CYRAMZA®, as a single agent, for the treatment of patients with hepatocellular carcinoma who have an alpha-fetoprotein of ≥400 ng/mL and have been treated with sorafenib. CYRAMZA is an antiangiogenic therapy. [Eli Lilly and Company] Press Release REGENXBIO announced an update to its Phase I/IIa trial of RGX-314 for the treatment of wet age-related macular degeneration (wet AMD), since its previously reported interim results. REGENXBIO announced it expects to file a new IND for a Phase II trial evaluating RGX-314 in subjects with diabetic retinopathy in the second half of 2019. [REGENXBIO Inc.] Press Release | |
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POLICY NEWSAcademics Raise Concerns About Predatory Journals on PubMed The National Library of Medicine has quality control procedures in place, but some researchers believe additional scrutiny is necessary. [The Scientist] Editorial US Lawmakers Propose Plan to Reduce Primate Research at National Institutes of Health The US National Institutes of Health (NIH) would be required to reduce its use of non-human primates in research, under a spending bill approved on 8 May by a committee in the US House of Representatives. The bill would direct the NIH “to accelerate efforts to reduce and replace the use of nonhuman primates with alternative research models” in its laboratories. [Nature News] Editorial Intolerance and Funding Concern Indian Scientists Ahead of Election A rising intolerance towards intellectuals and minority groups in India has prompted scientists there to speak out ahead of the country’s mammoth general election. More than 200 scientists have signed an open letter appealing to citizens to reject the discrimination and violence being promoted by some extremist groups. [Nature News] Editorial
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EVENTSNEW European CanCer Organisation (ECCO) 2019: European Cancer Summit Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Faculty Position – Vision Science (The University of Tennessee Health Science Center) Postdoctoral Researchers – Vascular Biology in Metabolic Disorders (Karolinska Institutet) Postdoctoral Position – The Vascular System in the Brain (Uppsala University) Research Associate – Cell Plasticity & Heterogeneity in Vascular Biology (University of Cambridge) Postdoctoral Position – Angiogenesis & Vascular Biology (Johns Hopkins University) Postdoctoral Position – Vascular Tissue Engineering (BioTis) Assistant/Associate Adjunct Professor – Cardiovascular Medicine (UC Davis) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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