Endothelial Cell News Volume 5.02 | Jan 20 2020

TOP STORY

Tissue-Engineered Vascular Grafts with Advanced Mechanical Strength from Human iPSCs

Researchers report generation of human induced pluripotent stem cell (iPSC)-derived tissue-engineered vascular grafts with mechanical strength comparable to native vessels used in arterial bypass grafts by utilizing biodegradable scaffolds, incremental pulsatile stretching, and optimal culture conditions. [Cell Stem Cell] Abstract | Press Release | Graphical Abstract

(Ranked by impact factor of the journal)

Ligand-Installed Anti-VEGF Genomic Nanocarriers for Effective Gene Therapy of Primary and Metastatic Tumors

The active targeted modulation of tumor microenvironments was schemed by developing hyaluronic acid-installed genomic nanocarriers for effectively ablation of both primary and metastatic tumors through anti-VEGF approach. [J Control Release] Full Article | Graphical Abstract

A Genome-Wide View of the De-Differentiation of Central Nervous System Endothelial Cells in Culture

Scientists compared transcriptional and accessible chromatin landscapes of acutely isolated mouse central nervous system (CNS) endothelial cells (ECs) versus mouse CNS ECs in short-term in vitro culture. [eLife] Full Article

Decreased CCN3 in Systemic Sclerosis Endothelial Cells Contributes to Impaired Angiogenesis

CCN3 expression was systematically decreased in the dermis of systemic sclerosis (SSc) patients compared to healthy controls, particularly in dermal blood vessels. Moreover, CCN3 was decreased in vitro in endothelial cells from SSc patients. [J Invest Dermatol] Abstract | Graphical Abstract

miR-130a and Tgfβ Content in Extracellular Vesicles Derived from the Serum of Subjects at High Cardiovascular Risk Predicts Their in-Vivo Angiogenic Potential

Investigators found that miR-130a and TGFβ content correlated with serum-derived extracellular vesicles in vitro and in vivo angiogenic properties, particularly in type 2 diabetic patients. [Sci Rep] Full Article

Endothelial Autophagy: An Effective Target for Radiation-Induced Cerebral Capillary Damage

Although in vivo neuron damage was observed after radiation exposure, further investigation found that zebrafish larvae didn’t respond to the same dosage of radiation in vitro, indicating that radiation induced neuron damage was a secondary-effect of cerebral vascular function damage. [Sci Rep] Full Article

Reactive Oxygen Species Production by BP-1,6-Quinone and Its Effects on Endothelial Dysfunction: Involvement of the Mitochondria

Researchers examined the redox activity of benzo-a-pyrene (BP)-1,6-quinone and mechanisms associated with it using EA.hy926 endothelial cells. [Toxicol Lett] Full Article

Pretreatment with Cilnidipine Attenuates Hypoxia/Reoxygenation Injury in HL-1 Cardiomyocytes through Enhanced NO Production and Action Potential Shortening

Cilnidipine enhanced phosphorylation of endothelial (e) nitric oxide (NO) synthase (eNOS) and NO production in a concentration-dependent manner, which was abolished by siRNAs against eNOS or an Hsp90 inhibitor, geldanamycin. [Hypertens Res] Abstract

The Proton-Sensing GPR4 Receptor Regulates Paracellular Gap Formation and Permeability of Vascular Endothelial Cells

Evaluation of GPR4 in the inflammatory response using the acute hindlimb ischemia-reperfusion mouse model revealed that GPR4 mediated tissue edema, inflammatory exudate formation, endothelial adhesion molecule expression, and leukocyte infiltration in the inflamed tissue. [iScience] Abstract | Full Article | Graphical Abstract

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Hypoxia-Inducible Factor-1α: The Master Regulator of Endothelial Cell Senescence in Vascular Aging

The authors focus on the regulation of senescence mediated by hypoxia-inducible factor-1α in age-related pathologies, with particular emphasis on the crosstalk between endothelial and vascular cells in age-associated atherosclerotic lesions. [Cells] Full Article | Graphical Abstract

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Imago Receives Fast Track Designation from US FDA for Bomedemstat for Treatment of Essential Thrombocythemia

Imago BioSciences, Inc. announced that the FDA has granted Fast Track designation for the development of bomedemstat for the treatment of essential thrombocythemia, a bone marrow disease associated with high platelet counts and potentially catastrophic vascular complications. [Imago BioSciences, Inc.] Press Release

Incyte Announces the Validation by the European Medicines Agency of Its Marketing Authorization Application for Pemigatinib in Patients with Cholangiocarcinoma

Incyte announced the validation of the company’s Marketing Authorization Application for pemigatinib for the treatment of adults with locally advanced or metastatic cholangiocarcinoma with a fibroblast growth factor receptor 2 fusion or rearrangement that is relapsed or refractory after at least one line of systemic therapy. [Incyte Corporation] Press Release

Senate Bill Would Boost Spending on Trump Administration’s Research Priorities

A bipartisan group of senators asked the Trump administration to pump up funding for a handful of technologies they believe will drive future US economic growth. [ScienceInsider] Editorial

Florida Cracks Down on Foreign Government Involvement in Research

Florida is launching a statewide investigation into US research exploitation after four University of Florida faculty members and six employees of Moffitt Cancer Center in Tampa failed to disclose ties to foreign programs, reports the Tampa Bay Times. [The Scientist] Editorial

NEW FGF Signaling: Understanding Function and Devising Therapeutic Tools
May 10-15, 2020
Lucca, Italy

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NEW Postdoctoral Fellow – Vascular Dysfunction in Neurodegeneration (Lund University)

Postdoctoral Fellow – Endothelial Biology (City of Hope)

Postdoctoral Researcher (University of Illinois at Chicago)

Tenure Track Faculty – Endothelial Cell Regeneration (Ohio State University)

Post-Doctoral Fellow – Metabolic Regulation of Vascular Formation (Oklahoma Medical Research Foundation)

Postdoctoral Position (University Hospital of Muenster)

PhD Student (University Hospital Carl Gustav Carus Dresden)

Postdoctoral Research Fellow – Pulmonary Vascular Diseases (Boston Children’s Hospital)

PhD Student – Aortic Disease (University Hospital of Cologne)

Postdoctoral Research Fellow – Aortic Disease (University Hospital of Cologne)

Postdoctoral Positions – Bioinformatics and Vascular Biology (KU Leuven)

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