Endothelial Cell News Volume 5.15 | Apr 27 2020

TOP STORY

Endothelial Cell Infection and Endotheliitis in COVID-19

The authors demonstrated endothelial cell involvement across vascular beds of different organs in a series of patients with COVID-19. [Lancet] Abstract

(Ranked by impact factor of the journal)

Notch Signaling Drives Synovial Fibroblast Identity and Arthritis Pathology

Scientists identified a critical role for NOTCH3 signaling in the differentiation of perivascular and sublining fibroblasts that expressed CD90. Using single-cell RNA sequencing and synovial tissue organoids, they found that NOTCH3 signaling drove both transcriptional and spatial gradients—emanating from vascular endothelial cells outwards—in fibroblasts. [Nature] Abstract

Endothelial E-Selectin Inhibition Improves Acute Myeloid leukemia Therapy by Disrupting Vascular Niche-Mediated Chemoresistance

Using acute myeloid leukemia (AML) mouse models, scientists showed AML blasts released inflammatory mediators that upregulated endothelial niche E-selectin expression. [Nat Commun] Full Article

Vascular Permeability in Retinopathy Is Regulated by VEGFR2 Y949 Signaling to VE-Cadherin

By challenging mouse models representing different steps in VEGFA/VEGF receptor 2 (VEGFR2)-induced vascular permeability, researchers showed that targeting signaling downstream of VEGFR2 pY949 limited vascular permeability in retinopathy induced by high oxygen or by laser-wounding. [eLife] Full Article

A Necroptotic-Independent Function of MLKL in Regulating Endothelial Cell Adhesion Molecule Expression

Investigators demonstrated that mixed-lineage kinase domain-like protein (MLKL) promoted vascular inflammation by regulating the expression of adhesion molecules ICAM1, VCAM1, and E-selectin in endothelial cells. [Cell Death Dis] Full Article

miR-548aq-3p Is a Novel Target of Far Infrared Radiation Which Predicts Coronary Artery Disease Endothelial Colony Forming Cell Responsiveness

Gene Ontology (GO) analysis of far infrared radiation (FIR) up-regulated genes indicated that the pathways enriched in FIR-responsive endothelial colony forming cells were involved in cell viability, angiogenesis and transcription. [Sci Rep] Full Article

S-Phase Kinase-Associated Protein-2 Rejuvenates Senescent Endothelial Progenitor Cells and Induces Angiogenesis In Vivo

Researchers investigated whether S-phase kinase-associated protein-2 plays a role in the regulation of endothelial progenitor cell senescence, which is closely associated with aging-related vasculopathy. [Sci Rep] Full Article

LncRNA OIP5-AS1 Promotes Cell Proliferation and Migration and Induces Angiogenesis via Regulating miR-3163/VEGFA in Hepatocellular Carcinoma

Scientists explored the inherent mechanism of lncRNA OIP5-AS1 in hepatocellular carcinoma (HCC). In the first place, qRT-PCR found that OIP5-AS1 and VEGFA expressions were significantly increased while miR-3163 was obviously reduced in HCC cells and tissues. [Cancer Biol Ther] Abstract

Euscaphic Acid and Tormentic Acid Protect Vascular Endothelial Cells against Hypoxia-Induced Apoptosis via PI3K/AKT or ERK 1/2 Signaling Pathway

Euscaphic acid protected vascular endothelial cells against hypoxia-induced apoptosis via ERK1/2 signaling pathway, and tormentic acid brought its efficacy into full play via PI3K/AKT and ERK1/2 signaling pathways. [Life Sci] Abstract

LncRNA SNHG1 Regulates Vascular Endothelial Cell Proliferation and Angiogenesis via miR-196a

The authors found SNHG1 was upregulated in TNF-α-treated HUVECs. They silenced SNHG1 and found it inhibited vascular endothelial cell proliferation and angiogenesis. [J Mol Histol] Abstract

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Sirtuins Family as a Target in Endothelial Cell Dysfunction: Implications for Vascular Aging

The authors summarize how sirtuin 1 and other sirtuins may contribute to endothelial cell function and how presence of diseased conditions may alter their expressions to cause endothelial dysfunction. [Biogerontology] Abstract

Visit our reviews page to see a complete list of reviews in the endothelial cell research field.

Adverum Biotechnologies Doses First Patient in Cohort 4 of OPTIC Phase I Clinical Trial of ADVM-022 Intravitreal Gene Therapy for Wet AMD

Adverum Biotechnologies, Inc. announced that the first patient was dosed in Cohort 4 of the ongoing OPTIC Phase I clinical trial for ADVM-022 for the treatment of wet age-related macular degeneration (AMD). [Adverum Biotechnologies, Inc.] Press Release

Chi-Med Announces Surufatinib Granted US FDA Fast Track Designations for the Treatment of Both Pancreatic and Non-Pancreatic Neuroendocrine Tumors

Hutchison China MediTech Limited announced that the FDA has granted two Fast Track Designations for the development of surufatinib, for the treatment of both advanced and progressive pancreatic neuroendocrine tumors (NET) and extra-pancreatic NET in patients who are not amenable for surgery. [Hutchison China MediTech Limited] Press Release

Open Science Takes On the Coronavirus Pandemic

When reports emerged in late 2019 of an outbreak of a new coronavirus centred in Wuhan, China, researchers at the virological-analysis website Nextstrain were ready. The open-source project tracks the spread of viruses through genetic variations in the sequences that scientists find. [Nature News] Editorial

Director of US Agency Key to Vaccine Development Leaves Role Suddenly Amid Coronavirus Pandemic

Rick Bright, one of the nation’s leading vaccine development experts and the director of the Biomedical Advanced Research and Development Authority, is no longer leading the organization. [STAT News] Editorial

In light of COVID-19, many conferences are being cancelled or postponed. As such:

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NEW Postdoctoral Positions – Bioinformatics and Vascular Biology (KU Leuven and Sun Yat-Sen University)

Biological Scientist – Lipid Metabolism and Dysregulation (University of Florida)

Research Associate – Cell Culturing (University of California Los Angeles Health)

Postdoctoral Fellow – Precision Oncology (Weill Cornell Medicine)

Postdoctoral Researchers – Cardiovascular Disease and Cancer (Terasaki Institute for Biomedical Innovation)

Research Assistant – Vascular Systems (University of Illinois at Chicago)

Postdoctoral Research Fellow – Molecular Oncology (Genentech, Inc.)

Postdoctoral Scientist – Gene Editing in Liver Disease (Beam Therapeutics)

Research Fellow – Cardiovascular Disease (Queen’s University Belfast)

Postdoctoral Researcher – Endothelial Mechanotransduction (KU Leuven)

Postdoctoral Researchers – Pancreatic-Endothelial Cell Interactions (German Research Center for Environmental Health)

Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.

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