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Pulmonary Cell News| Hepatic Cell News 3.39 October 18, 2019 | |
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TOP STORYThe expandable hepatic organoids (hEHOs) stably maintained phenotypic features of bipotential liver stem/progenitor cells that can differentiate into functional hepatocytes or cholangiocytes. The hEHOs could expand for 20 passages enabling large scale expansion to cell numbers requisite for industry or clinical programs. [Cell Res] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Two distinct populations of activated hepatic stellate cells (aHSCs) expressed WT1 after injury, and both re-engaged a transcriptional signature reflecting embryonic mesothelial origin of their discreet quiescent adult precursor. WT1-deletion enhanced fibrogenesis after injury, through upregulated Wnt-signaling and modulation of genes central to matrix persistence in aHSCs, and augmentation of myofibroblastic transition. [Nat Commun] Full Article With RNAi knockdown and CRISPR/Cas9 knockout models, investigators showed that inactivation of phosphoglycerate dehydrogenase (PHGDH) paralyzesd the serine synthesis pathway and reduced the production of αKG, serine, and NADPH. Concomitantly, inactivation of PHGDH elevated ROS level and induces HCC apoptosis upon Sorafenib treatment. [Nat Commun] Full Article By means of yes-associated protein (YAP) silencing and overexpression researchers demonstrated that YAP has a functional role in the repression of epithelial/hepatocyte differentiation by inversely modulating the expression of Snail and HNF4α at transcriptional level, through the direct occupancy of their promoters. [Cell Death Dis] Full Article LINC01224 and CHEK1 were up-regulated and miR-330-5p was downregulated in hepatocellular carcinoma cells. miR-330-5p shared negative correlations with LINC01224 and CHEK1, and LINC01224 shared a positive correlation with CHEK1. [Mol Ther Nucleic Acids] Abstract | Full Article 3D spheroids of adipose-derived mesenchymal stem cells were prepared by the hanging drop method. The efficacy of the 3D-ADSC to rescue FHF was evaluated in a D-galactosamine/lipopolysaccharide-induced mouse model of FHF via intraportal transplantation of the spheroids. [Stem Cell Res Ther] Full Article Downregulation of B7-H4 Suppresses Tumor Progression of Hepatocellular Carcinoma Knockdown B7-H4 expression induced HCC cells apoptosis by flow cytometry and colony formation assays and increased several apoptosis-related proteins, including survivin, cleaved caspase-3, cleaved caspase-7, and Bax, while the pro-growth protein survivin was reduced. Then the proliferation and cell cycle were suppressed after treated by siB7-H4. [Sci Rep] Full Article Mouse primary hepatic stellate cells and carbon tetrachloride -induced liver fibrosis model in mice were used as in vitro and in vivo models. The expression levels of miR-875-5p were detected by qRT-PCR. The validation of the direct target of miR-875-5p was through dual-luciferase reporter assay and western blotting assay. [J Gastroenterol Hepatol] Abstract The detection of cell growth and death rate were performed by hemacytometry and trypan blue staining, respectively. The expression of miR‐106b and SMAD7 mRNA in HCC cells was evaluated by qRT-PCR. [Cell Biol Int] Abstract Subscribe to one of our other 19 science newsletters such as Intestinal Cell News & Pancreatic Cell News. | |
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REVIEWSThe authors had previously shown that co-culture of cancer cells with mesenchymal stem cells (MSCs) could induce the reprogramming of MSCs into cancer stem cell-like cells. In this review, they evaluate the available data concerning the epigenetic regulation of miRNAs through methylation and the possible role of this regulation in stem cell and somatic reprogramming in hepatocellular carcinoma. [Front Cell Dev Biol] Full Article Visit our reviews page to see a complete list of reviews in the hepatic cell research field. | |
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INDUSTRY NEWSCan-Fite Completes Patient Enrollment in Phase II NASH Study of Namodenoson™ Can-Fite BioPharma Ltd. announce it has completed patient enrollment in its Phase II study of Namodenoson in the treatment of (non-alcoholic fatty liver disease NAFLD)/ non-alcoholic steatohepatitis (NASH). The multicenter, randomized, double-blinded, placebo-controlled, dose-finding efficacy and safety study has enrolled 60 patients with NAFLD with or without NASH. [Can-Fite BioPharma Ltd.] Press Release UTEP Receives $19M to Study Cancer Affecting Mexican-Americans The University of Texas at El Paso’s (UTEP) Border Biomedical Research Center will accelerate its quest to understand and identify the reasons for Hispanic cancer health disparities and its ultimate impact on the people of the Paso del Norte region thanks to a five-year, $19.2 million grant from the National Institutes of Health (NIH). [The University of Texas at El Paso] Press Release Dr. Josef Steiner Cancer Research Award 2019 Goes to Serena Nik-Zainal The Dr. Josef Steiner Cancer Foundation is awarding the Dr. Josef Steiner Cancer Research Award 2019 to Prof. Serena Nik-Zainal. The bioinformatician from the Department of Medical Genetics and the MRC cancer unit at the University of Cambridge is receiving the award in recognition of her groundbreaking research in developing new methods in the field of bioinformatics for the clinically-relevant classification of tumors. [The University of Bern (EurekAlert!)] Press Release | |
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POLICY NEWSBrexit Hits UK Science Funding and Workforce The first figures have emerged demonstrating that Brexit uncertainty has adversely affected UK research. They show Britain’s annual share of EU research funding has fallen by nearly a third since 2015. [The BBC] Editorial Scientific Integrity Bill Advances in US House with Bipartisan Support Despite their failure to attract a single Republican co-sponsor, Democrats in Congress have long insisted that a bill to strengthen scientific integrity across US government agencies takes a bipartisan stance and is not a veiled attack on the Trump administration’s attitude toward science. That claim of bipartisanship took a big step forward as the science committee of the US House of Representatives tweaked the bill to satisfy key Republicans on the panel. [ScienceMagazine] Editorial
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EVENTSNEW The International Liver Congress 2020 Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Scientist – RAS Cancer Biology (Genetech, Inc.) Postdoctoral Associates – Organogenesis of Liver, Heart and Pancreas (The University of Manchester) Assistant Professor – Liver Research (The University of Hong Kong) Research Associate – Pluripotent Stem Cells in Liver Development (The Wellcome Institute) Postdoctoral Researcher – Gene Regulation in Liver Cancer (Umeå University) Chief Editor – Nature Ageing (Nature Research) Research Scientist – Fibrosis (Gilead Sciences, Inc.) Postdoctoral Researchers – Liver Diseases (Albert Einstein College of Medicine) Postdoctoral Researcher – Liver Cell-Cell Interactions (Flanders Institute for Biotechnology) Postdoctoral Researcher – Liver Disease (Albert Einstein College of Medicine) Principal Researcher – Systems Disease Biology (Boehringer Ingelheim) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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