Hepatic Cell News 3.46 December 6, 2019 | |
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TOP STORYThe authors demonstrated that carbon tetrachloride injection into mice activated type 1 innate lymphoid cells (ILC1s), but not natural killer cells, in the liver. Activated ILC1s produced interferon-γ and protected mice from CCl 4-induced acute liver injury. IFN-γ released from activated ILC1s promoted the survival of hepatocytes through upregulation of Bcl-xL. [Immunity] Abstract | Graphical Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Researchers found that mechanical tension-induced yes-associated protein activation triggers hepatocyte dedifferentiation. Alleviation of mechanical tension by confining cell spreading is sufficient to inhibit hepatocyte dedifferentiation. [Cell Rep] Full Article | Graphical Abstract Despite significant effort, the molecular basis for metformin response remains poorly understood, with a limited number of specific biochemical pathways studied to date. To broaden our understanding of hepatic metformin response, they combined phospho-protein enrichment in tissue from genetically engineered mice with a quantitative proteomics platform to enable the discovery and quantification of basophilic kinase substrates in vivo. [Cell Rep] Abstract | Graphical Abstract Investigators evaluated the impacts of using single cell dispersion of iPS-derived parenchymal versus using induced-pluriptent derived hepatocyte-like cells spheroids, both in combination with non-parenchymal cells, into final liver tissue functionality. Single cell constructs showed reduced cell survival and hepatic function and unbalanced protein/amino acid metabolism when compared to spheroid printed constructs after 18 days in culture. [Biofabrication] Full Article SPIN1 Triggers Abnormal Lipid Metabolism and Enhances Tumor Growth in Liver Cancer Tissue microarray showed that 75% of hepatocellular carcinoma (HCC) tissues were positive for SPIN1, which was highly expressed in clinical HCC samples and positively associated with malignancy of HCC. Strikingly, SPIN1 could modulate abnormal lipid metabolism by increasing intracellular triglycerides, cholesterols, and lipid droplets in hepatoma cells, which could remarkably enhance the proliferation of hepatoma cells. [Cancer Lett] Abstract The authors analyzed STMN1 expression and the related clinical significance in hepatocellular carcinoma (HCC) by using well-established Protein Atlas, TCGA and GEO cancer databases. The analysis indicated that STMN1 was highly expressed in HCC and closely associated with vascular invasion, higher histological grade, advanced clinical grade and shorter survival time in HCC patients. [Cancer Sci] Abstract Lotus Seedpod Extracts Reduced Lipid Accumulation and Lipotoxicity in Hepatocytes Oleic acid (OA), an unsaturated fatty acid, was used to induce the phenotype of NAFLD in human hepatocytes, HepG2 cells. LSE dose-dependently improved the OA-induced viability loss of HepG2 cells. [Nutrients] Full Article Researchers found that Proprotein convertase subtilisin/kexin type 9 (PCSK9) increased significantly in human and BDL mouse injured liver tissues, so did hepatocyte nuclear factor-1 alpha and SREBP2. No significant difference of plasma PCSK9 was observed. Inhibited PCSK9 using CRISPR-PCSK9 adeno-associated virus in BDL mice ameliorated liver inflammation and fibrosis, with LPS decrease in serum, without any change in intestinal wall integrity. [Inflammation] Abstract Investigators explored a three-step protocol to rapidly induce human minor salivary gland mesenchymal stem cells into hepatocytes in vitro, and finally obtained hepatocyte-like cells within six days. After a series of relevant detection from gene, protein and functional levels, they confirmed that the finally induced cells were mature hepatocyte-like cells with certain hepatocyte functions to some extent. [Biochem Biophys Res Commun] Abstract Researchers investigated the inhibitory effects of platyconic acid A (PA) on TGF-1-induced activation of hepatic stellate cells (HSCs). PA inhibited TGF-1-enhanced cell proliferation, as well as expression of -SMA and collagen 1 in HSC-T6 cells. PA suppressed TGF-1-induced smad2/3 phosphorylation and smad binding elements 4 luciferase activity. [Cells] Abstract | Download Full Article Scientists investigated the clinical significance and biological functions of DKK1 in hepatocellular carcinoma (HCC). The expression of DKK1 was examined in cirrhotic and HCC tissues by immunohistochemistry and quantitative real-time PCR. DKK1 was silenced or overexpressed in HCC cell lines, and in vitro and in vivo studies were performed. [Signal Transduct Target Ther] Full Article Subscribe to one of our other 19 science newsletters such as Intestinal Cell News & Pancreatic Cell News. | |
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REVIEWSTumor Evolution in Hepatocellular Carcinoma Studies using next-generation sequencing of multiple regions of the same tumor nodule suggest different patterns of HCC evolution and confirm the high molecular heterogeneity in a subset of patients. Different hypotheses have been proposed to explain tumor evolution, including clonal selection or neutral and punctuated acquisition of genetic alterations. [Nat Rev Gastroenterol Hepatol] Press Release Visit our reviews page to see a complete list of reviews in the hepatic cell research field. | |
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INDUSTRY NEWSTetra Bio-Pharma Receives FDA Orphan Drug Designation for Hepatocellular Carcinoma Tetra Bio-Pharma Inc. announced it has received FDA Orphan Drug Designation for delta-9-tetrahydrocannabinol in the treatment of hepatocellular carcinoma. [Tetra Bio-Pharma Inc.] Press Release Cold Spring Harbor Lab Wins Grant for Cancer Research Cold Spring Harbor Laboratory has won a $750,000 grant from TD Bank to support its new cancer research facility. The award is part of the TD Ready Challenge, an initiative to provide financial support to organizations that have developed solutions to improve detection and intervention of diseases. [Sacred Heart University] Press Release | |
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POLICY NEWSScience Publishers Review Ethics of Research on Chinese Minority Groups Two science publishers are reviewing the ethics of research papers in which scientists backed by China’s government used DNA or facial-recognition technology to study minority groups in the country, such as the predominantly Muslim Uyghur population. [Nature News] Editorial What the United Kingdom’s ‘Brexit Election’ Means for Science The United Kingdom’s three main political parties have each pledged to increase spending on science, ahead of a general election overshadowed by the country’s vote three and a half years ago to leave the European Union. [Nature News] Editorial
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EVENTSNEW Advances in Liquid Biopsies Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Fellow – Liver Pathology (University of Illinois at Chicago) NEW Professor – Hepatology (Jena University Hospital) Postdoctoral Researcher – HIV and the Liver (Seattle’s Children’s Hospital) Postdoctoral Researcher – Oncogenic Pathways (University of Liège) Faculty Member – Pathogen-Associated Malignancies (Fred Hutchinson Cancer Research Center) Postdoctoral Fellow – Drug-Induced Liver Injury (Johnson & Johnson) Postdoctoral Researcher – Liver Disease Treatment (University of Southern Denmark) Postdoctoral Researcher – Personalized Medicine (Mayo Clinic Center for Individualized Medicine) Postdoctoral Scientist – RAS Cancer Biology (Genetech, Inc.) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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