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Pulmonary Cell News| Hematopoiesis News 10.41 October 22, 2019 | |
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TOP STORYStem Cells Have a Unique Way of Handling Stress That Protects Them Activating a pro-survival stress response unique to stem cells protects them through the stress of self-renewal, with significant implications for improving stem cell transplants in the future. For the first time, research by Dr. John Dick and Dr. Stephanie Xie identifies a link between lipid metabolism and cellular stress protective programs which are able to shepherd blood stem cells through the stress of multiplying in a cell-culture dish. [Press release from University Health Network discussing online prepublication in Cell Stem Cell] Press Release | Full Article | Graphical Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Scientists established an Rbpj-inducible system that allowed temporal and tissue-specific control of the responsiveness to Notch in all hematopoietic cells. Using this system, they found that Notch signaling was required before the early T cell progenitor stage in the thymus. [Nat Immunol] Abstract Investigators showed that temporary coapplication of the cyclic resveratrol trimer caraphenol A enhanced lentiviral vector (LV) gene delivery efficiency to human and nonhuman primate hematopoietic stem and progenitor cells with integrating and nonintegrating LVs. [Blood] Abstract CX3CR1+ mononuclear cells sensed microbiota-derived molecules via endolysosomal Toll-like receptors to produce inflammatory cytokines, which controlled the basal expansion of hematopoietic progenitors, but not HSCs, and their differentiation potential toward myeloid lineages. [Blood] Abstract Functional Profiling of Single CRISPR/Cas9-Edited Human Long-Term Hematopoietic Stem Cells Targeted short isoform expression of the GATA1 transcription factor elicit distinct differentiation and proliferation effects in single highly purified long-term-HSC when analyzed with functional in vitro differentiation and long-term repopulation xenotransplantation assays. [Nat Commun] Full Article Researchers demonstrated that transgenic overexpression of the wild type sphingosine-1-phosphate receptor 3 in murine HSCs was sufficient to induce a transplantable myeloid leukemia. [Leukemia] Abstract Scientists applied RIG-I agonists to stimulate type I interferons production in murine models of conditioning therapy with total body irradiation and graft-versus-host disease. [Sci Rep] Full Article CLINICAL RESEARCHGWAS of Mosaic Loss of Chromosome Y Highlights Genetic Effects on Blood Cell Differentiation In a cohort of 95,380 Japanese men, investigators identified 50 independent genetic markers in 46 loci associated with mosaic loss of chromosome Y at a genome-wide significant level, 35 of which were unreported. Lead markers overlapped enhancer marks in HSCs. [Nat Commun] Full Article Retrospective analysis of HSC transplant recipients from 2004 to 2015 evaluated vaccination uptake and compared invasive pneumococcal disease rates in patients receiving pneumococcal polysaccharide vaccine and pneumococcal conjugate vaccination. [Biol Blood Marrow Transplant] Abstract Subscribe to one of our other 19 science newsletters such as Cord Blood News & Cell Therapy News. | |
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REVIEWSSphingosine 1-Phosphate: Lipid Signaling in Pathology and Therapy The abundance of circulatory sphingosine 1-phosphate (S1P) and the high expression of S1P receptors in exposed cells—that is, vascular and hematopoietic cells—poses a key question of how this signaling axis is regulated. Although further work is needed, S1P-targeted approaches may be useful in regenerative therapies for the aging and diseased myocardium. [Science] Abstract | Graphical Abstract Metalloproteases: On the Watch in the Hematopoietic Niche Metalloproteases and their inhibitors can impact the bioavailability of important local signals that instruct mammalian HSC fate and function in the hematopoietic niche. Despite growing evidence, metalloprotease/tissue inhibitors of metalloprotease proteins are currently underappreciated as important modulators of hematopoiesis. [Trends Immunol] Full Article Visit our reviews page to see a complete list of reviews in the hematopoiesis research field. | |
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INDUSTRY NEWSGenmab A/S announced that the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency has issued a positive opinion recommending broadening the existing marketing authorization for daratumumab in the European Union. [Genmab A/S] Press Release Rafael Pharmaceuticals, Inc. announced that it has entered into a collaboration with the National Cancer Institute (NCI), part of the NIH. This collaboration will test devimistat, Rafael’s first-in-class clinical lead compound, in cytokine independent human T-cell leukemia virus type 1 (HTLV-1) associated adult T-cell leukemia/lymphoma. [Rafael Pharmaceuticals, Inc. (GlobeNewswire, Inc.)] Press Release Nektar Therapeutics announced the initiation of a first-in-human, Phase I clinical study evaluating NKTR-255, an interleukin-15 (IL-15) receptor agonist, as monotherapy for patients with relapsed or refractory non-Hodgkin lymphoma or multiple myeloma. [Nektar Therapeutics] Press Release UCLA Opens CAR T Clinical Trial Targeting Most Common Types of Lymphoma and Leukemia The UCLA Jonsson Cancer Center has launched a pioneering chimeric antigen receptor (CAR) T cell immunotherapy trial that will attack cancer cells by simultaneously recognizing two targets – CD19 and CD20 – that are expressed on B-cell lymphoma and leukemia. [UCLA Jonsson Cancer Center] Press Release | |
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POLICY NEWSFemale Researchers in Australia Less Likely to Win Major Medical Grants than Males Female scientists in Australia were less likely to win a major type of medical-research grants this year than their male counterparts, despite an overhaul of the country’s science funding that was supposed to address gender inequity. [Nature News] Editorial Trump Names Seven to Revived Presidential Science Advisory Panel Thirty-three months after taking office, President Donald Trump has chosen a group of business leaders to advise him on science and technology policy. [ScienceInsider] Editorial
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EVENTSNEW European Calcified Tissue Society (ECTS) Congress NEW Tissue Engineering and Regenerative Medicine International Society (TERMIS) European Chapter Meeting 2020 Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW PhD Project – Physical Biology of Blood Stem Cells (University of York) Postdoctoral Fellowship (Versiti Blood Research Institute) Postdoctoral Research Fellowship (New York Blood Center) Faculty Positions – Gene Editing (Indiana University School of Medicine) Postdoctoral Fellowship – Hematopoietic Cell Transplantation (University of Maryland) Chair – Inflammation and Hematopoiesis (Technische Universität Dresden) Postdoctoral Scholar – Hematopoietic Cells (Penn State University) Postdoctoral Fellowship – Leukemia Pathogenesis (BC Cancer) Faculty – Hematopoietic Biology and Malignancy (MD Anderson Cancer Center) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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