Hematopoiesis News Volume 10.42 | Oct 29 2019

TOP STORY

Inducible Histone K-to-M Mutations Are Dynamic Tools to Probe the Physiological Role of Site-Specific Histone Methylation In Vitro and In Vivo

Researchers generated mouse models expressing inducible histone H3 lysine-to-methionine (K-to-M) mutants, which globally inhibited methylation at specific sites. Mice expressing H3K36M developed severe anemia with arrested erythropoiesis, a marked HSC defect, and rapid lethality. [Nat Cell Biol] Abstract

(Ranked by impact factor of the journal)

Thiopurine-Mediated Impairment of Hematopoietic Stem and Leukemia Cells in Nudt15^R138C Knock-In Mice

Scientists established knock-in mice harboring p.Arg138Cys (Nudt15^R138C), which corresponded to the human polymorphism. A clinically relevant dose of mercaptopurine induced lethal cytopenia in Nudt15^R138C-harboring mice. [Leukemia] Abstract

EBV BCL-2 Homologue BHRF1 Drives Chemoresistance and Lymphomagenesis by Inhibiting Multiple Cellular Pro-Apoptotic Proteins

BHRF1 interacted with the cellular pro-apoptotic BCL-2 proteins, BIM, BID, PUMA and BAK, but its capability to inhibit apoptosis could not be mapped solely to one of these interactions, suggesting plasticity is a key feature of BHRF1. [Cell Death Differ] Abstract

Interleukin-6 Signaling Regulates Hematopoietic Stem Cell Emergence

The authors showed that interleukin-6R (IL6R) via IL6 was required and sufficient for HSC generation. They found that Notch activated IL6R by regulating its expression in the hemogenic endothelium and in HSCs. [Exp Mol Med] Full Article

Hematopoietic Npc1 Mutation Shifts Gut Microbiota Composition in Ldlr^-/- Mice on a High-Fat, High-Cholesterol Diet

Investigators explored whether a hematopoietic Npc1 mutation, induced via bone marrow transplantation, influenced gut microbiota composition in low-density lipoprotein receptor knockout (Ldlr^-/-) mice fed a high-fat, high-cholesterol diet for 12 weeks. [Sci Rep] Full Article

A Microfluidic Device to Enhance Viral Transduction Efficiency during Manufacture of Engineered Cellular Therapies

Researchers demonstrated that a microfluidic transduction device could improve the efficiency of lentiviral transduction for both T-cell and HSC targets by greater than two fold relative to static controls. [Sci Rep] Full Article

A Novel Murine Model of Differentiation-Mediated Cytomegalovirus Reactivation from Latently Infected Bone Marrow Hematopoietic Cells

Scientists found that while mouse cytomegalovirus could infect a broad range of hematopoietic bone marrow cells, latent virus is only detectable in HSCs, myeloid progenitor cells, monocytes and dendritic cell-enriched cell subsets. [J Gen Virol] Abstract

CLINICAL RESEARCH

Loss of Lkb1 Impairs Treg Function and Stability to Aggravate Graft-versus-Host Disease after Bone Marrow Transplantation

Investigators demonstrated that regulatory T cells (Tregs) were more dramatically decreased in bone marrow compared with those in peripheral blood from acute graft-versus-host disease patients and that bone marrow Treg defects were negatively associated with hematopoietic reconstitution. [Cell Mol Immunol] Full Article

Immunogenicity of the Inactivated Influenza Vaccine in Children Who Have Undergone Allogeneic Haematopoietic Stem Cell Transplant

A prospective multicentre study was conducted to evaluate the immunogenicity of the inactivated influenza vaccine in children who have undergone HSC transplant compared with healthy age-matched controls. [Bone Marrow Transplant] Abstract

Subscribe to one of our other 19 science newsletters such as Cord Blood News & Cell Therapy News.

Myeloid-Derived Suppressor Cells in Hematological Malignancies: Friends or Foes

The authors review the various characteristics and functions of myeloid-derived suppressor cells (MDSCs), as well as the potential therapeutic applications of MDSCs in hematological malignancies, including lymphoma, multiple myeloma, leukemia, and hematopoietic stem cell transplantation. [J Hematol Oncol] Full Article

Visit our reviews page to see a complete list of reviews in the hematopoiesis research field.

Pascal Biosciences and Y-Biologics Announce Research Collaboration for Development of a Bispecific Antibody for Leukemia

Pascal Biosciences Inc. and Y-Biologics announced a research collaboration agreement for the discovery and development of novel bispecific antibodies for the treatment of leukemia. [Pascal Biosciences, Inc. (GlobeNewswire, Inc.)] Press Release

NIH and Gates Foundation Launch Effort to Bring Genetic Cures for HIV, Sickle Cell Disease to World’s Poor

The National Institutes of Health and the Bill and Melinda Gates Foundation will together invest at least $200 million over the next four years to develop gene-based cures for sickle cell disease and HIV with an attribute even rarer in the world of genetic medicine than efficacy. [National Institutes of Health (STAT)] Press Release

Actinium Announces Positive Interim Results from Iomab-B Pivotal Phase III SIERRA Trial at 50% of Total Patient Enrollment

Actinium Pharmaceuticals, Inc. announced key interim findings from the pivotal Phase III SIERRA trial of Iomab-B, including feasibility and safety data, at 50% of total patient enrollment. [Actinium Pharmaceuticals, Inc.] Press Release

UCL to Phase Out Single-Use Plastics, Including Pipette Tips

University College London made a series of pledges last week to cut down on plastic waste, help mitigate climate change, and make its research and teaching facilities more environmentally sustainable. [TheScientist] Editorial

German University Finds ‘Severe’ Misconduct by Researcher Who Promoted Questionable Cancer Blood Test

A university commission announced this week it had found evidence of “extensive and severe scientific misconduct” by Christof Sohn, director of the women’s clinic at Heidelberg University Hospital in Germany and the lead researcher behind a highly publicized but questionable blood test designed to detect breast cancer. [ScienceMagazine] Editorial

NEW The Life of the Skeleton from Embryonic Development to Aging
February 2-7, 2020
Galveston, Texas, United States

Visit our events page to see a complete list of events in the community.

NEW Assistant/Associate Professor – Hematology & Oncology (UC Davis School of Medicine)

NEW Associate/Professor – Hematology & Oncology (UC Davis School of Medicine)

PhD Project – Physical Biology of Blood Stem Cells (University of York)

Postdoctoral Fellowship (Versiti Blood Research Institute)

Postdoctoral Research Fellowship (New York Blood Center)

Faculty Positions – Gene Editing (Indiana University School of Medicine)

Postdoctoral Fellowship – Hematopoietic Cell Transplantation (University of Maryland)

Postdoctoral Scholar – Hematopoietic Cells (Penn State University)

Postdoctoral Fellowship – Leukemia Pathogenesis (BC Cancer)

Faculty – Hematopoietic Biology and Malignancy (MD Anderson Cancer Center)

Postdoctoral Positions – Stem Cell Biology, Cancer Biology, and Epigenetics (Baylor College of Medicine)

Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.

Have we missed an important article or publication in Hematopoiesis News? Click here to submit!

Comments or suggestions? Submit your feedback here.