Immunology of Infectious Disease News 7.02 January 23, 2019 | |
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TOP STORYPrevention of Tuberculosis Infection and Disease by Local BCG in Repeatedly Exposed Rhesus Macaques The authors showed that pulmonary Bacillus Calmette-Guérin (BCG) prevents infection by using a repeated limiting-dose Mycobacterium tuberculosis challenge model and identify polyfunctional T-helper type 17 cells, interleukin-10 and immunoglobulin A as correlates of local protective immunity. [Nat Med] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Investigators isolated peripheral blood mononuclear cells from 28 patients with chronic hepatitis D virus (HDV) and HBV infection, identified HDV-specific CD8+ T-cell epitopes and characterized HDV-specific CD8+ T cells. They associated these with HDV sequence variations and clinical features of patients. [Gastroenterology] Abstract Interferon Lambda Protects the Female Reproductive Tract against Zika Virus Infection Scientists showed that treatment of primary human vaginal and cervical epithelial cells with interferon (IFN)-α/β or IFN-λ induces host defense transcriptional signatures and inhibits Zika virus infection. [Nat Commun] Full Article Cross-Lineage Protection by Human Antibodies Binding the Influenza B Hemagglutinin Investigators developed novel influenza B virus (IBV) hemagglutinin (HA) probes to interrogate humoral responses to IBV in humans. A significant proportion of IBV HA-specific B cells recognise both B/Victoria/2/87-like and B/Yamagata/16/88-like lineages in a distinct pattern of cross-reactivity. [Nat Commun] Full Article Scientists demonstrated that blood CD4 T cells from HIV-infected patients, with or without ART, exhibited significantly lower levels of cofilin phosphorylation than those from healthy controls; cofilin hyperactivation was also associated with poor CD4 T cell recovery following ART. [Sci Adv] Full Article Direct Inhibition of Hepatitis B Virus e Antigen by Core Protein Allosteric Modulator The authors showed that in contrast to phenylpropenamide series compound AT‐130, a novel heteroaryldihydropyrimidine core protein allosteric modulator, HAP_R01, reduced hepatitis B e antigen levels in multiple in vitro and in vivo hepatitis B virus experimental models. [Hepatology] Abstract Researchers showed that M. tuberculosis-infected stat3fl/fl lysm cre mice, defective for STAT3 in myeloid cells, contained lower bacterial load in lungs and spleens, reduced granuloma extension but higher levels of pulmonary neutrophils. [PLoS Pathog] Full Article Scientists studied the role of PD-1 pathway and macrophage polarization on M. tuberculosis-specific CD8+ T cell-induced macrophage death. They observed that both PD-L1 on CD14+ cells and PD-1 on CD8+ T cells were highly expressed at the site of infection in pleurisy TB patients’ effusion samples. [Sci Rep] Full Article Proteo-Transcriptomic Dynamics of Cellular Response to HIV-1 Infection Researchers investigated the dynamic host response to HIV-1 infection by systematically measuring transcriptomic, proteomic, and phosphoproteomic expression changes in infected and uninfected SupT1 CD4+ T cells at five time points of the viral replication process. [Sci Rep] Full Article Intramuscular immunization in mice with OVX836 induced strong nucleoprotein-specific CD4+ and CD8+ T-cell systemic responses and established CD8+ tissue memory T cells in the lung parenchyma. [npj Vaccines] Full Article Subscribe to our sister publications: Human Immunology News & Immune Regulation News. | |
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REVIEWSSodium in the Microenvironment Regulates Immune Responses and Tissue Homeostasis Sodium intake may influence the activation status of the immune system through direct effects on T helper cell subsets and innate immune cells in tissues such as the skin and other target organs. [Nat Rev Immunol] Abstract Visit our reviews page to see a complete list of reviews in the immunology of infectious disease research field. | |
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INDUSTRY NEWSCocrystal Pharma, Inc. announced safety and preliminary efficacy data for its U.S. Phase IIa study evaluating CC-31244 for the ultra-short treatment of hepatitis C virus infected individuals. [Cocrystal Pharma, Inc.] Press Release UK marketing authorization has been granted for Sanofi Pasteur’s Trivalent Influenza Vaccine (Split Virion, Inactivated) High Dose (TIV High Dose), which is indicated for active immunization of people 65 years of age and older against influenza disease. [Sanofi Pasteur (GlobeNewswire, Inc.)] Press Release PrimeVax Immuno-Oncology, Inc. announced that the company has just signed an exclusive, worldwide license with the US Army Medical Materials Development Activity, Ft. Detrick, MD, USAMMDA, authorizing PrimeVax to use dengue virus-1 #45AZ5 strain for treatment of cancer. [PrimeVax Immuno-Oncology, Inc. (PR Newswire Association LLC.)] Press Release U.S. Patent Office Issues CEL-SCI Two Patents for Its LEAPS Vaccine Platform Technology CEL-SCI Corporation announced the U.S. Patent and Trademark Office has issued two new U.S. patents for the company’s LEAPS platform technology. [CEL-SCI Corporation (Business Wire, Inc.)] Press Release | |
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POLICY NEWSNeglected-Disease Research Funding Hits Record High Research funding for diseases that predominantly affect people living in poverty hit a record high in 2017, according to a report released on 23 January by Policy Cures Research, a global-health think tank in Sydney, Australia. [Nature News] Editorial Brazil’s New President Has Scientists Worried. Here’s Why Brazil has long been a frontrunner in climate change policy and environmental diplomacy. The international conventions on climate change and biological diversity, for example, were born during the historic United Nations Earth Summit in Rio de Janeiro in 1992, and Brazil played a key role in crafting and implementing both agreements. That legacy is now at risk. [ScienceInsider] Editorial Number of EU Research Students in Britain Drops from Pre-Referendum High The number of postgraduate researchers at UK universities who come from other European Union countries has fallen since the Brexit referendum in June 2016. [Nature News] Editorial CRISPR-Baby Scientist Fired by University The scientist who announced last year that he had produced the world’s first gene-edited babies has been fired by his university. [Nature News] Editorial
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EVENTSNEW Gordon Research Conference: Tuberculosis Drug Discovery & Development Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Senior Lecturer – Infection Immunology (University of Gothenburg) Postdoctoral Fellow – Immunology/Immunometabolism (Technische Universitat Braunschweig) Project Research Scientist – Malaria (The Francis Crick Institute) Senior Scientist and Postdoctoral Positions – HIV Molecular Virology (Buck Institute) Full Professor – Molecular and Experimental Virology (University of Veterinary Medicine Hannover) PhD Student Positions – Infection Biology of Human Pathogens (The Max von Pettenkofer Institute) Assistant/Associate/Full Professor – Virology (University of Maryland at Baltimore) Lectureship – Infectious Diseases (King’s College London) Postdoctoral Fellow – Immunology (Rutgers-New Jersey Medical School) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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