Immune Regulation News 11.48 December 20, 2019 | |
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TOP STORYA Class of γδ T Cell Receptors Recognize the Underside of the Antigen-Presenting Molecule MR1 Scientists describe a diverse population of human γδ T cells isolated from peripheral blood and tissues that exhibit autoreactivity to the monomorphic major histocompatibility complex-related protein 1 (MR1). [Science] Abstract | Press Release | |
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PUBLICATIONS(Ranked by impact factor of the journal)An Intrinsic Role of IL-33 in Treg Cell-Mediated Tumor Immunoevasion Researchers identified a cell-intrinsic role of the alarmin interleukin (IL)-33 in the functional stability of regulatory T (Treg) cells. [Nat Immunol] Abstract T Cells Instruct Myeloid Cells to Produce Inflammasome-Independent IL-1β and Cause Autoimmunity Investigators describe an inflammasome-independent pathway of IL-1β production that was triggered upon cognate interactions between effector CD4+ T cells and mononuclear phagocytes. [Nat Immunol] Abstract In a targeted screen of C-type lectin receptors, a Clec2d reporter responded to lysates from necrotic cells. Biochemical purification identified histones, both free and bound to nucleosomes or neutrophil extracellular traps, as Clec2d ligands. [Immunity] Abstract | Graphical Abstract The authors reveal the pathophysiology of Susac syndrome (SuS), an enigmatic neuroinflammatory disease with central nervous system (CNS) endotheliopathy. By investigating immune cells from the blood, cerebrospinal fluid, and CNS of SuS patients, they demonstrated oligoclonal expansion of terminally differentiated activated cytotoxic CD8+ T cells. [Nat Commun] Full Article Chemical Functionality of Multidomain Peptide Hydrogels Governs Early Host Immune Response Scientists evaluated the early inflammatory host response to four multidomain peptide hydrogels displaying amines, guanidinium ions, and carboxylates in a subcutaneous injection model. While all the studied peptide materials possessed similar nanostructure and physical properties, they triggered markedly different inflammatory responses. [Biomaterials] Abstract Adoptive transfer of plasmacytoid dendritic cells (pDCs) or administration of IFN-α to neonatal mice prevented the development of allergic inflammation in wild type but not in IFNAR1−/− mice. Similarly, adult mice developed more severe allergic inflammation when pDCs were depleted. [Cell Mol Immunol] Full Article B7H4 Expression in Tumor Cells Impairs CD8 T Cell Responses and Tumor Immunity Researchers assessed B7 homolog 4 (B7H4) expression cell types in human breast cancer tissues and addressed its potential mechanisms in the CD8 T cell immune response. [Cancer Immunol Immunother] Full Article Toll-Like Receptor 4 Inhibition Prevents Autoimmune Diabetes in NOD Mice The authors determined the role of TLR4 in the activation and proliferation of T lymphocytes in the onset of autoimmune diabetes, using the non-obese diabetic (NOD) mouse model. Antigen-specific activation and proliferation of diabetogenic T cells were assessed in vitro by carboxyfluorescein succinimidyl ester dilution, in presence of vehicle or CLI-095, a cyclohexene derivative that inhibited TLR4 signaling. [Sci Rep] Full Article Contribution of ROS and Metabolic Status to Neonatal and Adult CD8+ T Cell Activation Scientists evaluated the impact of the cytoplasmic and mitochondrial levels of reactive oxygen species (ROS) of adult and neonatal CD8+ T cells on their activation potential. They constructed a logical model connecting metabolism and ROS with T cell signaling. [PLoS One] Full Article Investigators showed that an innate immune collectin, pulmonary surfactant protein-D (SP-D), attenuated lipopolysaccharide (LPS)-mediated NETosis in human neutrophils by binding to LPS. [Commun Biol] Full Article Subscribe to our sister publications: Human Immunology News & Immunology of Infectious Disease News. | |
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REVIEWSExhaustion and Senescence: Two Crucial Dysfunctional States of T Cells in the Tumor Microenvironment The authors discuss the unique phenotypic and functional characteristics of these two types of dysfunctional T cells and their roles in tumor development and progression. In addition, they further discuss the potential molecular and metabolic signaling pathways responsible for the control of T-cell exhaustion and senescence in the suppressive tumor microenvironment. [Cell Mol Immunol] Abstract Visit our reviews page to see a complete list of reviews in the immune regulation research field. | |
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INDUSTRY NEWSRheos Medicines announced that it has entered into a worldwide exclusive collaboration, option and license agreement with Roche to discover, develop and commercialize novel therapeutics in the field of immunometabolism. [Rheos Medicines] Press Release Turnstone Biologics announced a strategic collaboration with Takeda Pharmaceutical Company Limited to develop multiple products from its proprietary vaccinia virus platform targeting a broad range of cancer indications. [Turnstone Biologics (Business Wire, Inc.)] Press Release New Phase III Study Shows Positive Results for Benlysta® in Lupus Nephritis The Lupus Research Alliance shared news from GSK that Benlysta demonstrated positive clinical trial results in treating lupus nephritis, a common complication of lupus causing inflammation of the kidneys that can result in end-stage kidney disease. [The Lupus Research Alliance] Press Release Oncodesign announced the selection of ODS-101 as a drug candidate for auto-immune and inflammatory disease indications. [Oncodesign] Press Release Alligator Bioscience: First Patient Dosed with ATOR-1017 Developed for Metastasized Cancer Alligator Bioscience announced that the first patient has been successfully dosed in the Phase I study with the wholly owned 4-1BB antibody ATOR-1017, which is being developed for the treatment of metastasized cancer. [Alligator Bioscience AB] Press Release AbbVie announced that the European Commission has approved RINVOQ™ for the treatment of adult patients with moderate to severe active rheumatoid arthritis who have responded inadequately to, or who are intolerant to one or more disease-modifying anti-rheumatic drugs. [AbbVie, Inc.] Press Release Agenus Commences Combination Trial of Its Next-Gen CTLA-4 with its PD-1 Antibody Agenus Inc. announced the first patient dosed with AGEN1181, an anti-CTLA-4 antibody, in combination with balstilimab, Agenus’ PD-1 inhibitor. [Agenus, Inc.] Press Release Grifols Launches XEMBIFY® 20% Subcutaneous Immunoglobulin, a New Primary Immunodeficiency Treatment Grifols announced the launch of its latest immunoglobulin innovation, XEMBIFY®, the company’s first 20% subcutaneous immunoglobulin therapy for the treatment of patients two years of age and older with primary immunodeficiency. [Grifols] Press Release | |
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POLICY NEWS2020 US Spending Bill Restricts Some Animal Research, Pushes for Lab Animal Retirement Federal research agencies will be under increased pressure to reduce their use of monkeys, dogs, and cats when President Donald Trump signs the final 2020 US spending bill. [ScienceInsider] Editorial Trump Picks Computer Scientist to Lead National Science Foundation US President Donald Trump has nominated Sethuraman Panchanathan, a computer scientist researcher and vice-president at Arizona State University in Tempe, to be the next head of the National Science Foundation. [Nature News] Editorial
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