Mammary Cell News Volume 11.18 | May 16 2019

TOP STORY

Evaluating Cell Lines as Models for Metastatic Breast Cancer through Integrative Analysis of Genomic Data

Investigators reveal substantial genomic differences between breast cancer cell lines and metastatic breast cancer patient samples. [Nat Commun] Full Article | Press Release

(Ranked by impact factor of the journal)

An Integrated Stress Response via PKR Suppresses HER2⁺ Cancers and Improves Trastuzumab Therapy

Researchers showed an anti-tumor function of the protein kinase PKR and its substrate eIF2α in a mouse HER2⁺ breast cancer model. [Nat Commun] Full Article

Therapeutic Cooperation between Auranofin, a Thioredoxin Reductase Inhibitor and Anti‐PD‐L1 Antibody for Treatment of Triple‐Negative Breast Cancer

Treatment with auranofin, an FDA‐approved thioredoxin reductase inhibitor caused specific cell death and impaired the growth of triple‐negative breast cancer cells grown as spheroids. [Int J Cancer] Abstract

Parthenolide Covalently Targets and Inhibits Focal Adhesion Kinase in Breast Cancer Cells

Scientists studied the parthenolide mechanism of action using activity-based protein profiling-based chemoproteomic platforms to map additional covalent targets engaged by parthenolide in human breast cancer cells. [Cell Chem Biol] Abstract | Graphical Abstract

Hypoxia‐Induced Secretion Stimulates Breast Cancer Stem Cell Regulatory Signaling Pathways

The authors describe the mechanism by which hypoxia‐induced secretion influences cancer stem cell (CSC) spreading. Conditioned media from estrogen receptor‐α positive hypoxic breast cancer cell cultures increased the fraction of CSCs compared to normal growth conditions, as determined using sets of CSC assays and model systems. [Mol Oncol] Abstract | Full Article

A 3D Bioprinter Platform for Mechanistic Analysis of Tumoroids and Chimeric Mammary Organoids

Investigators recently described a low-cost bioprinting platform designed to be accessible for basic cell biology laboratories. Here they report the use of this system for the study of tumorigenesis and microenvironmental redirection of breast cancer cells. [Sci Rep] Full Article

Vitamin D3 Constrains Estrogen’s Effects and Influences Mammary Epithelial Organization in 3D Cultures

Scientists investigated the role of vitamin D3 (vitD3) in mammary epithelial morphogenesis using two 3D culture models. VitD3 interfered with estrogen’s actions on T47D human breast cancer cells in 3D differently at different doses, and recapitulated what was observed in vivo. [Sci Rep] Full Article

The MicroRNA‐141‐3p/CDK8 Pathway Regulates the Chemosensitivity of Breast Cancer Cells to Trastuzumab

miR‐141‐3p was downregulated in drug‐resistant cell lines. Cyclin‐dependent kinase 8 (CDK8) was proved to be a target gene of miR‐141‐3p. [J Cell Biochem] Abstract

Resistin Induces Breast Cancer Cells Epithelial to Mesenchymal Transition (EMT) and Stemness through Both Adenylyl Cyclase-Associated Protein 1 (CAP1)-Dependent and CAP1-Independent Mechanisms

Researchers showed that resistin increased the migration of MCF-7 and MDA-MB-231 cells and induced the formation of cellular protrusions through reorganization of F-actin filaments. [Cytokine] Abstract

Silibinin-Induced Apoptosis of Breast Cancer Cells Involves Mitochondrial Impairment

The authors report that silibinin decreased the mitochondrial mass in terms of MitoTracker Green staining in breast cancer cells. Silibinin induced morphological changes of mitochondria from oval to truncated or fragmented shapes accordingly. [Arch Biochem Biophys] Abstract

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Breast Cancer Tumor Stroma: Cellular Components, Phenotypic Heterogeneity, Intercellular Communication, Prognostic Implications and Therapeutic Opportunities

Several factors expressed by the stroma of breast carcinomas are associated with the development of metastasis, such as matrix metalloproteases, their tissular inhibitors or some of their regulators like integrins, cytokines or toll-like receptors. [Cancers] Abstract | Download Full Article

Plasticity and Potency of Mammary Stem Cell Subsets during Mammary Gland Development

The authors focus on current research on the biology of normal mammary stem cells with an emphasis on properties of cellular plasticity, self-renewal and quiescence, as well as the role of the microenvironment in regulating these processes. [Int J Mol Sci] Full Article

Visit our reviews page to see a complete list of reviews in the mammary cell research field.

Myriad Genetics to Present Multiple Studies

Myriad Genetics, Inc. announced that it will present results from multiple studies. [Press release from Myriad Genetics, Inc. discussing research to be presented at the 2019 American Society of Clinical Oncology (ASCO) Annual Meeting, Chicago] Press Release

Biothera Pharmaceuticals to Present Clinical Data from Phase II Triple Negative Breast Cancer Study

Biothera Pharmaceuticals, Inc. announced that it will present primary clinical data from its Phase II study in chemo-refractory metastatic triple negative breast cancer. [Press release from Biothera Pharmaceuticals, Inc. discussing research to be presented at the 2019 American Society of Clinical Oncology (ASCO) Annual Meeting, Chicago] Press Release

MacroGenics Announces Positive Results from Phase III SOPHIA Study of Margetuximab in Patients with HER2-Positive Metastatic Breast Cancer

MacroGenics, Inc. announced additional details of the results from the Phase III SOPHIA study of margetuximab in patients with HER2-positive metastatic breast cancer who have previously been treated with anti-HER2-targeted therapies. [Press release from MacroGenics, Inc. discussing research to be presented at the 2019 American Society of Clinical Oncology (ASCO) Annual Meeting, Chicago] Press Release

LifeNet Health Unveils Center of Excellence for Research in San Diego

LifeNet Health announced the opening of a San Diego facility that stands as a Center of Excellence for its life sciences and tissue-engineering programs, as well as a logistical hub for hospital and surgeon clients on the West Coast. [LifeNet Health] Press Release

MDI Biological Laboratory Receives $18 Million for Biomedical Research and Training

The MDI Biological Laboratory has received an award of nearly $18 million from the National Institute of General Medical Sciences, an institute of the National Institutes of Health, for the renewal of a grant to strengthen biomedical research and research training in Maine. [MDI Biological Laboratory] Press Release

Senate Panel Delays Good-Government Bill, Scolds HHS for ‘Moving the Goal Posts’

A Senate panel delayed action on a bipartisan bill to improve government transparency among advisory bodies in deference to concerns from the National Institutes of Health that the legislation would seriously disrupt the agency’s ability to review research proposals. [ScienceInsider] Editorial

To Meet the ‘Plan S’ Open-Access Mandate, Journals Mull Setting Papers Free at Publication

Plan S, the funder-backed scheme to require free online access to scientific literature, aims to shake up the subscription journals that have long dominated scholarly publishing. Now, some publishers are considering an approach they hope will both comply with the plan and maintain their subscription income: allowing authors to post manuscripts in public archives as soon as their papers are published. [ScienceInsider] Editorial

NEW 2019 Till & McCulloch Meetings
November 4-6, 2019
Montreal, Quebec, Canada

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Fellows – Bioinformatics (IRCCS European Institute of Oncology)

Research Assistant – Anti-Breast Cancer Drugs (United Arab Emirates University)

Postdoctoral Fellowship – Redox Biology of Breast and Lung Cancer (Washington University School of Medicine)

Postdoctoral Fellowship – PcG-Mediated Mechanisms in Breast Cancer (University of Miami)

Postdoctoral Research Position – Molecular Biology & Cancer Research (Augusta University)

Postdoctoral Fellowship – Tumor Suppressor CSMD1 (Lund University)

Postdoctoral Position – Breast Cancer Research (Massachusetts General/Harvard Medical School)

Faculty Position – Breast and Ovarian Cancer (Fred Hutchinson Cancer Research Center)

Postdoctoral Fellowship – Breast Cancer Research (Washington University School of Medicine)

Postdoctoral Associate – Cancer Immunology (The Jackson Laboratory)

Postdoctoral Fellow – Cancer Bioinformatics (BC Cancer Research Center, PHSA)

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