Mammary Cell News Volume 11.34 | Sep 5 2019

TOP STORY

Protein C Receptor Is a Therapeutic Stem Cell Target in a Distinct Group of Breast Cancers

Scientists showed that protein C receptor (Procr)⁺ cells were enriched for cancer stem cells in Wnt1 basal-like tumors, but not in Brca1 basal-like tumors or PyVT luminal tumors. [Cell Res] Abstract

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Single-Cell Transcriptomics Reveals Multi-Step Adaptations to Endocrine Therapy

Researchers dissected the contributions of clonal genetic diversity and transcriptional plasticity during the early and late phases of endocrine therapy at single-cell resolution. [Nat Commun] Full Article

Timeless-Stimulated miR-5188-FOXO1/β-Catenin-c-Jun Feedback Loop Promotes Breast Cancer Stemness through FOXO1-Mediated β-Catenin Ubiquitination

The authors showed that miR-5188 exerted an oncogenic effect by inducing breast cancer stemness, proliferation, metastasis, and chemoresistance in vitro and in vivo. [Mol Ther] Abstract | Graphical Abstract

Eribulin Rapidly Inhibits TGF-β-Induced Snail Expression and Can Induce Slug Expression in a Smad4-Dependent Manner

The effects of microtubule targeting agents on regulators of TGF-β-induced epithelial-to-mesenchymal transition were evaluated in breast cancer cell lines using high content imaging, gene and protein expression, siRNA-mediated knockdown and chromatin immunoprecipitation. [Br J Cancer] Full Article

MicroRNA-222 Reprogrammed Cancer-Associated Fibroblasts Enhance Growth and Metastasis of Breast Cancer

Breast normal fibroblasts or cancer-associated fibroblasts were isolated from cancers by laser microdissection or were cultured. Fibroblasts were transfected to manipulate miR-222 or Lamin B receptor. The fibroblast-conditioned medium was collected and used to treat epithelial BC lines MDA-MB-231 and MDA-MB-157. [Br J Cancer] Abstract

Mathematical Modeling of Drug-Induced Receptor Internalization in the HER2-Positive SKBR3 Breast Bancer Cell-Line

Investigators studied the early impact of trastuzumab on HER2 internalization and recycling in the HER2-overexpressing breast cancer cell line SKBR3. [Sci Rep] Full Article

ADAM15 Mediates Upregulation of Claudin-1 Expression in Breast Cancer Cells

Scientists created isogenic cell panels expressing five A disintegrin and metalloproteinase-15 (ADAM15) variants including wild-type and catalytically inactive forms. The expression of ADAM15 isoforms in MDA-MB-231 cells led to cell clustering to varying degree, without changes in EMT markers vimentin, slug and E-cadherin. [Sci Rep] Full Article

Higher Glucose Enhances Breast Cancer Cell Aggressiveness

Using lowly metastatic MCF-7 and highly metastatic MDA-MB231 breast cancer cells – highly incident cancer types – the authors established how glucose metabolism regulates actin and the biochemical changes that leads to alterations of cell mechanical properties. [Nutr Cancer] Abstract

LncRNA HEIH Regulates Cell Proliferation and Apoptosis through miR-4458/SOCS1 Axis in Triple-Negative Breast Cancer

Researchers found that hepatocellular carcinoma up-regulated EZH2-associated long non-coding RNA (HEIH) was overexpressed in triple-negative breast cancer tissues and cell lines compared with adjacent normal mammary tissues and normal mammary epithelial cell line, respectively. [Hum Cell] Abstract

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Mechanisms of Chemotherapy Resistance in Triple-Negative Breast Cancer—How We Can Rise to the Challenge

The authors outline the role of crucial pathways in triple-negative breast cancer survival following chemotherapy treatment and highlight the importance of using combinatorial drug strategies and incorporating biomarkers in clinical studies. [Cells] Full Article

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European Commission Approves Roche’s Tecentriq in Combination with Abraxane for People with PD-L1-Positive, Metastatic Triple-Negative Breast Cancer

Roche announced that the European Commission has approved Tecentriq^® plus chemotherapy for the treatment of adult patients with unresectable locally advanced or metastatic triple-negative breast cancer whose tumors have PD-L1 expression and who have not received prior chemotherapy for metastatic disease. [F. Hoffmann-La Roche Ltd] Press Release

Mary Kay Goes Global with Cancer Research Grant

The Mary Kay Foundation announced that it is awarding its long-time partner UT Southwestern Medical Center a $500,000 global research grant for funding efforts to search for cures for breast, uterine, cervical and ovarian cancers. [Park Cities People] Press Release

World Health Organization Backs Open-Access Plan S

The World Health Organization is joining cOAlition S, a growing group of agencies and charities that fund scientific research and that require their grantees to share their work in open-access journals or repositories. [The Scientist] Editorial

New Memo Offers First Glimpse of How Trump’s Science Adviser Would Like to Shape Spending Priorities

A new White House directive laying out next year’s spending priorities for federal research agencies describes a US science enterprise imperiled by internal problems and foreign governments. [ScienceInsider] Editorial

UK Science Minister Jo Johnson Resigns Amid Brexit Drama

UK science minister Jo Johnson has resigned from his position as universities and science minister and as a member of the House of Commons, citing conflicts between what he thinks is best for the country and family ties. [Nature News] Editorial

NEW Cancer Evolution and Combinatorial Cancer Therapies: Concepts and Challenges
January 19-23, 2020
Banff, Alberta, Canada

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NEW Postdoctoral Research Fellow – Epithelial Growth in Development and Cancer (Fred Hutchinson Cancer Research Center)

NEW Project Scientist – Breast and Hematological Tumors (Cedars-Sinai)

NEW Postdoctoral Research Scientist – Role of Cancer-Associated Fibroblast Metabolism in Breast Cancer (Cancer Research UK Beatson Institute)

Scientific Communications Coordinator (STEMCELL Technologies Inc.)

Postdoctoral Fellow – Breast and Prostate Cancer (Mayo Clinic Comprehensive Cancer Center)

Research Assistant – Endocrinology in Breast Cancer and Diabetes (Northwell Health)

Bioinformatician – Breast Cancer (Royal College of Surgeons in Ireland)

Postdoctoral Fellow – T-Cell Immunotherapy in Cancers (Memorial Sloan Kettering Cancer Center)

Research Officer – Tumor Progression in Breast and Prostate Cancer (Garvan Institute of Medical Research)

Research Lab Specialist – Tumor Microenvironment & Cell Behavior (University of Southern California)

Postdoctoral Associate – Immune Responses (The Jackson Laboratory)

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