Mammary Cell News Volume 12.14 | Apr 16 2020

TOP STORY

Loss of ELF5-FBXW7 Stabilizes IFNGR1 to Promote the Growth and Metastasis of Triple-Negative Breast Cancer through Interferon-γ Signalling

Scientists revealed that loss of the tumor suppressive transcription factor Elf5 in triple negative breast cancer cells activated intrinsic interferon-γ signalling, promoting tumour progression and metastasis. [Nat Cell Biol] Abstract

(Ranked by impact factor of the journal)

PHF20L1 as a H3K27me2 Reader Coordinates with Transcriptional Repressors to Promote Breast Tumorigenesis

Researchers concluded that TUDOR domain–containing PHF20L1 as a H3K27me2 reader exerted transcriptional repression by recruiting polycomb repressive complex 2 PRC2) and Mi-2/nucleosome remodeling and deacetylase(NuRD) complex, linking PRC2-mediated methylation and NuRD-mediated deacetylation of H3K27. [Sci Adv] Full Article

Cdk4 and Cdk6 Couple the Cell-Cycle Machinery to Cell Growth via mTORC1

Scientists showed that CyclinD-Cdk4/6 activated mTORC1 by binding and phosphorylating TSC2 on Ser1217 and Ser1452. [Cell Rep] Full Article | Graphical Abstract

Sporadic Activation of an Oxidative Stress–Dependent NRF2-p53 Signaling Network in Breast Epithelial Spheroids and Premalignancies

Researchers found regulatory state heterogeneity was jointly coordinated by the NRF2 and p53 pathways, which were costabilized by spontaneous oxidative stress within 3D cultures. [Sci Signal] Full Article

Crosstalk between Hydroxytyrosol, a Major Olive Oil Phenol, and HIF-1 in MCF-7 Breast Cancer Cells

Investigation into MCF-7 breast cancer cells indicated that hydroxytyrosol decreased hypoxia inducible factor-1α protein, probably by downregulating oxidative stress and by inhibiting the PI3K/Akt/mTOR pathway. [Sci Rep] Full Article

CDDO-Me Alters the Tumor Microenvironment in Estrogen Receptor Negative Breast Cancer

Scientists showed that CDDO-methyl ester remodels the breast tumor microenvironment, redirecting tumor associated microphages activation and T cell tumor infiltration in vivo.” [Sci Rep] Full Article

Morphology, Motility, and Cytoskeletal Architecture of Breast Cancer Cells Depend on Keratin 19 and Substrate

The authors ablated the expression of keratin 19(K19) in breast cancer cells of the MDA-MB-231 cell line and found that cells lacking K19 became more elongated in culture, with morphological reversion toward the parental phenotype upon transduction of KRT19. [Cytometry A] Abstract

Astrocytic IGFBP₂ and CHI₃L₁ in Cerebrospinal Fluid Drive Cortical Metastasis of HER₂₊Breast Cancer

Investigators hypothesized that factors in cerebrospinal fluid play a critical role in the adaptation, proliferation, and establishment of cortical metastases. [Clin Exp Metastasis] Abstract

Triaryl Dicationic Dna Minor-Groove Binders with Antioxidant Activity Display Cytotoxicity and Induce Apoptosis in Breast Cancer

Scientists report the potent cytotoxic effect of a series of repurposed flexible bis-imidamides 1–4, triaryl bis-guanidine 5 and bis-N-substituted guanidines 6,7 having a 1,4-diphenoxybenzene scaffold backbone on MCF-7 and MDA-MB-231 breast cancer cell lines. [Chem Biol Interact] Abstract | Graphical Abstract

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Overcoming Endocrine Resistance in Breast Cancer

The authors review recent advances in delineating mechanisms of resistance to endocrine therapies and potential strategies to overcome such resistance. [Cancer Cell] Abstract

Visit our reviews page to see a complete list of reviews in the mammary cell research field.

Antengene Announces Dosing of First Patient in the ATG-019 (KPT-9274) Phase I Trial, a First-in-Class Dual Inhibitor, for Advanced Solid Tumors and Non-Hodgkin’s Lymphoma

Antengene announced that it has dosed the first patient in Taiwan, China in its Phase I open-label clinical trial of ATG-019 (KPT-9274), a dual inhibitor of both p21-activated kinase 4 and nicotinamide phosphoribosyl transferase. [Antengene Corporation] Press Release

Pattern Computer Receives Positive Pre-Clinical Test Results for Breast Cancer Drug Candidates

Pattern Computer^®, Inc. announced that two sets of drug therapy candidates targeting breast cancer – identified through its proprietary machine-learning pattern discovery system – completed final in vitro organoid testing from a leading national lab demonstrating “significant synergistic interaction” in killing malignant tumor growth, with statistically low to no adverse effects on healthy cell states. [Pattern Computer] Press Release

WHO’s Tedros, Expressing ‘Regret’ over Trump Move to Cut Funding, Says His Focus Is on ‘Saving Lives’

The head of the World Health Organization expressed “regret” that President Trump intends to cut off US funding to the agency over its handling of the coronavirus, but pointedly avoided criticizing the US move. [STAT News] Editorial

Ending Coronavirus Lockdowns Will Be a Dangerous Process of Trial and Error

After the novel coronavirus made its way from China around the world, one country after another adopted harsh measures to stop SARS-CoV-2 from spreading and overwhelming hospitals. They have hit the pause button on their economies and their citizens’ lives, stopping sports events, religious services, and other social gatherings. [ScienceInsider] Editorial

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NEW Postdoctoral Researcher – Cell Growth and Metabolism (The University of Texas Southwestern Medical Center)

NEW Postdoctoral Fellow – Precision Oncology (Weill Cornell Medicine)

NEW Research Assistant – Live Animal and Tissue Culture (MD Anderson Cancer Center)

Senior Scientist – Cancer Immunology and Immunotherapy (Genentech, Inc.)

Tenure Track Faculty Positions – Breast Cancer (Georgetown University Medical Center)

Research Fellow – Breast Cancer (Dana-Farber Cancer Institute)

Postdoctoral Position – Cancer Genomics and Epigenomics Research (NIH National Cancer Institute)

Postdoctoral Fellow – RAS Cancer Cell Biology (University of Luxembourg)

Group Leaders – Cancer Biology (Institute of Pharmacology and Structural Biology)

Postdoctoral Training Fellow – Endocrine Control Mechanisms (Institute of Cancer Research)

Postdoctoral Investigator – Breast Cancer Cell Biology (Florida Atlantic University)

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