Mesenchymal Cell News Volume 11.34 | Sep 3 2019

TOP STORY

Noninvasive Application of Mesenchymal Stem Cell Spheres Derived from hESC Accelerates Wound Healing in a CXCL12-CXCR4 Axis-Dependent Manner

Spheres generated from human embryonic stem cell-derived MSC (EMSC_Sp) were directly dropped onto excised wounds in mice; the effects of EMSC_Sp were compared to those of dissociated EMSC. [Theranostics] Full Article

(Ranked by impact factor of the journal)

IN VITRO

ALK^ATI Interacts with c-Myc and Promotes Cancer Stem Cell-Like Properties in Sarcoma

Overexpression of anaplastic lymphoma kinase (ALK)^ATI promoted cancer stem cell-like properties in sarcoma cells by promoting sphere formation and upregulating the expression of stem cell markers. [Oncogene] Abstract

Surface Water Extracts Impair Gene Profiles and Differentiation in Human Mesenchymal Stem Cells

Surface water extracts at noncytotoxic concentrations induced 533 to 1055 differentially expressed genes (DEGs) in human bone MSCs after 48 hours of exposure. A total of 370 genes were commonly affected by surface water from different sites and accounted for 35–69% of DEGs impaired by individual sample. [Environ Int] Full Article | Graphical Abstract

The High-Density Lipoprotein Receptor Scarb1 Is Required for Normal Bone Differentiation In Vivo and In Vitro

In normal adrenocorticotropic hormone, osteogenic differentiation in vitro from mesenchymal stem cells showed reduced alkaline phosphatase and mineralization. [Lab Invest] Abstract

Injury-Preconditioning Secretome of UCMSCs Amplified the Neurogenesis and Cognitive Recovery after Severe Traumatic Brain Injury in Rats

To simulate the complex microenvironment in the injured brain well, investigators used traumatically injured brain tissue extracts to pretreat umbilical cord MSCs (UCMSCs) in vitro and stereotaxically injected the secretome from traumatic injury-preconditioned UCMSCs into the dentate gyrus of the hippocampus in a rat severe traumatic brain injury model. [J Neurochem] Abstract

Concentration-Dependent Cellular Behavior and Osteogenic Differentiation Effect Induced in Bone Marrow Mesenchymal Stem Cells Treated with Magnetic Graphene Oxide

Magnetic graphene oxide (MGO) was fabricated, and previously undiscovered relationships — including cellular behavior and the effects of osteogenic differentiation and related mechanisms of MGO in rat bone‐marrow-derived mesenchymal stem cells — were investigated for the first time. [J Biomed Mater Res A] Abstract

Transforming Growth Factor-β1 and Hypoxia Inducible Factor-1α Synergistically Inhibit the Osteogenesis of Periodontal Ligament Stem Cells

Researchers found that the expression of hypoxia-inducible factor-1α and transforming growth factor-β1 was enhanced in the osteogenesis of periodontal ligament stem cells under nonhypoxic conditions. [Int Immunopharmacol] Abstract

IN VIVO

Human Adipose Tissue Mesenchymal Stem Cells as a Novel Treatment Modality for Correcting Obesity Induced Metabolic Dysregulation

Scientists injected human adipose tissue derived mesenchymal stem cells suspension, conditioned medium and the cell lysate intramuscularly in high fat diet-induced C57BL/6 mice. [Int J Obes] Abstract

Construction of a Biomimetic Chemokine Reservoir Stimulates Rapid In Situ Wound Repair and Regeneration

The authors successfully developed a chemokine loaded biomimetic hydrogel as a functional reservoir to stimulate the rapid in situ recruitment of BMSCs for fast wound repair and regeneration. [Int J Pharm] Abstract

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A Comparison of Phenotypic and Functional Properties of Mesenchymal Stromal Cells and Multipotent Adult Progenitor Cells

Both multipotent adult progenitor cells and mesenchymal stromal cells are bone-marrow derived, non-hematopoietic adherent cells, that are well-known for having immunomodulatory and pro-angiogenic properties, whilst being relatively non-immunogenic. The authors compare the phenotypic and functional properties of these two cell types, to help in determining which would be the superior cell type for different applications. [Front Immunol] Full Article

Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field.

FDA Provides Guidance on Clinical Pathway to Marketing Application for Revascor in End-Stage Heart Failure Patients with an LVAD

Mesoblast Limited announced positive outcomes from its recent meeting with the FDA on the pathway for marketing authorization of its allogeneic cell therapy product candidate Revascor in end-stage heart failure patients implanted with a left ventricular assist device (LVAD). [Mesoblast Limited] Press Release

Steadman Philippon Research Institute to Share Four DOD Research Grants Aimed at Reducing Risk of Osteoarthritis & Reducing Long-Term Disability Among Military Service Members and Veterans

Steadman Philippon Research Institute (SPRI) has been awarded a contract from the Department of Defense (DOD) Office of Naval Research totaling $4.5 million to support four research projects aimed at reducing the risk of osteoarthritis later in life and reducing long term disability among active duty service members and veterans. [Steadman Philippon Research Institute (GlobeNewswire, Inc.)] Press Release

As Hurricane Dorian Bears Down, Researchers Get Ready

For the fourth consecutive year, scientists in Florida are preparing for a major hurricane, laying down sandbags and boarding up windows at research facilities along the state’s Atlantic coast. [ScienceInsider] Editorial

Foreign Interference under the Spotlight at Australian Universities

The Australian government says it will establish an expert committee to detect and respond to cyberattacks, intellectual-property theft and other strikes against universities by foreign governments or groups. The move comes amid growing concerns from some politicians and academics about foreign influence at Australian campuses. [Nature News] Editorial

NEW European Calcified Tissue Society (ECTS) Congress
May 16-19, 2020
Marseille, France

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Researcher – Proteoglycans in Post-Traumatic Osteoarthritis (Drexel University)

Scientific Communications Coordinator (STEMCELL Technologies Inc.)

Postdoctoral Researcher – Cell Cycles in Stem Cells (University of California, Santa Cruz)

Postdoctoral Researcher – Development and Stem Cell Biology (California Institute of Technology)

Postdoctoral Researcher – Stem Cells (GlaxoSmithKline plc.)

Postdoctoral Researchers – Stem Cell Biology (Simon Fraser University)

Postdoctoral Researcher – MSCs in Accelerated Aging Treatment (MD Anderson Cancer Center)

Postdcotral Research – MSC Donation (MD Anderson Cancer Center)

Postdoctoral Researcher – Sarcoma and Leukemia (Cedars-Sinai Medical Center)

Postdoctoral Fellow – Immunology & Respiratory Disease Research with MSCs (Boehringer Ingelheim)

Development Scientist – Cell Therapy (GE)

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