Mesenchymal Cell News Volume 12.01 | Jan 14 2020

TOP STORY

Integrin-Specific Hydrogels Modulate Transplanted Human Bone Marrow-Derived Mesenchymal Stem Cell Survival, Engraftment, and Reparative Activities

Researchers showed that synthetic hydrogels presenting integrin-specific peptides enhanced the survival, persistence, and osteo-reparative functions of human bone marrow-derived MSCs transplanted in murine bone defects. [Nat Commun] Full Article

(Ranked by impact factor of the journal)

IN VITRO

Polymeric Sheet Actuators with Programmable Bioinstructivity

The authors employed a programmable polymer actuator sheet to autonomously synchronize thermal and mechanical signals applied to MSCs. Using a grid on its underside, the shape change of polymer sheet, as well as cell morphology, calcium influx, and focal adhesion assembly, was visualized and quantified. [Proc Natl Acad Sci USA] Abstract | Press Release

Dopamine D1 Receptor-Mediated Activation of the ERK Signaling Pathway Is Involved in the Osteogenic Differentiation of Bone Mesenchymal Stem Cells

Investigators evaluated the influence of both dopamine D1 and D2 receptor activation on bone MSC osteogenic differentiation. Gene and protein expression of osteogenic-related markers were tested. [Stem Cell Res Ther] Abstract

The Influence of Cell Culture Density on the Cytotoxicity of Adipose-Derived Stem Cells Induced by L-Ascorbic Acid-2-Phosphate

The relationship between adipose-derived stem cell (ASC) seeding density and acid-2-phosphate (A2-P)-induced cytotoxicity was investigated. Spheroid-derived ASCs with smaller cellular dimensions were generated to investigate the effect of cell-cell contact on the resistance to A2-P-induced cytotoxicity. [Sci Rep] Full Article

Orbital Seeding of Mesenchymal Stromal Cells Increases Osteogenic Differentiation and Bone‐Like Tissue Formation

Investigators applied a simple, dynamic seeding method using an orbital shaker to seed human bone marrow-derived MSCs on silk fibroin scaffolds. [J Orthop Res] Full Article

Tenocyte-Imprinted Substrate: A Topography-Based Inducer for Tenogenic Differentiation in Adipose Tissue-Derived Mesenchymal Stem Cells

The tenogenic differentiation induction capacity of tenocytes replica in ADSCs was investigated and compared with other groups including tissue replica, decellularized tendon, and BMP-12 as other potentially inducers. [Biomed Mater] Abstract

Downregulation of lncRNA DANCR Promotes Osteogenic Differentiation of Periodontal Ligament Stem Cells

Researchers aimed to find out the relationship between long non-coding RNA (lncRNA) DANCR and the proliferation and osteogenic differentiation of periodontal ligament stem cells. [BMC Dev Biol] Full Article

Epiregulin Promotes Osteogenic Differentiation and Inhibits Neurogenic Trans‐Differentiation of Adipose‐Derived Mesenchymal Stem Cells via MAPKs Pathway

The authors investigated the role and mechanism of EREG on the osteogenic differentiation and neurogenic trans‐differentiation in adipose‐derived stem cells. [Cell Biol Int] Abstract

IN VIVO

Rapamycin-Preactivated Autophagy Enhances Survival and Differentiation of Mesenchymal Stem Cells after Transplantation into Infarcted Myocardium

Scientists investigated cytoprotective effect of rapamycin-preactivated autophagy on survival of the transplanted MSCs. MSCs isolated from rat bone marrow were treated with 50 nmol/L rapamycin for two hours, and then the cytoprotective effect of rapamycin was examined. [Stem Cell Rev Rep] Full Article

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Potential of Mesenchymal Stem Cells for Bioengineered Blood Vessels in Comparison with Other Eligible Cell Sources

The authors survey the potential of MSCs for engineering functional blood vessels in comparison with other cell types including bone marrow mononuclear cells, endothelial precursor cells, differentiated adult autologous smooth muscle cells, autologous endothelial cells, embryonic stem cells, and induced pluripotent stem cells. [Cell Tissue Res] Abstract

Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field.

NANOBIOTIX Announces Plan for Global Phase III Head and Neck Cancer Registration Trial Along with Overall Development Update

NANOBIOTIX, Corp. announced its global development strategy for 2020 and beyond, following proof-of-concept and European market approval for NBTXR3 in locally advanced soft tissue sarcoma of the extremities and trunk wall in 2019. [NANOBIOTIX, Corp.] Press Release

UK Regulatory Authority Approves Cynata’s Phase II Clinical Trial in Critical Limb Ischemia

Cynata Therapeutics Limited announced that it has received approval from the UK Medicines and Healthcare products Regulatory Agency to proceed with its Phase II clinical trial of the Cymerus™ MSC product CYP-002 in patients with critical limb ischaemia. [Cynata Therapeutics Limited (GlobeNewswire, Inc.)] Press Release

FDA and NIH Let Clinical Trial Sponsors Keep Results Secret, Investigation Shows

For 20 years, the US government has urged companies, universities, and other institutions that conduct clinical trials to record their results in a federal database, so doctors and patients can see whether new treatments are safe and effective. [STAT News] Editorial

Protect India’s Universities

For several weeks the world has watched as India’s citizens – including academics and students – have taken to the streets. Tens of thousands have been gathering to read out the preamble to the Indian constitution, as a mark of protest against a discriminatory new citizenship law. [Nature News] Editorial

NEW Lorne Cancer Conference
February 13-15, 2020
Lorne, Australia

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Associate – Cartilage Regeneration (Drexel University)

NEW Postdoctoral Scholar – Corneal Stem Cells (University of California, Los Angeles)

Senior Research Technician – Stem Cell Biology (Columbia University in the City of New York)

PhD Positions – Cell Biology (University of Warwick)

Postdoctoral Positions – Cell and Molecular Biology (University of Copenhagen)

PhD Student – Mammalian Development and Disease (Max Planck Institute for Molecular Genetics)

Postdoctoral Positions – Drug Delivery and Therapeutic Development (University of Minnesota)

Postdoctoral Researcher – Immuno-Oncology (Essen University Hospital)

Research Fellow – Stem Cell Biology & Engineering (New York Blood Center)

Faculty Positions – Regenerative Medicine (Guangzhou Regenerative Medicine and Health Guangdong Laboratory)

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