Neural Cell News 13.38 October 2, 2019 | |
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TOP STORYMiro1 Marks Parkinson’s Disease Subset and Miro1 Reducer Rescues Neuron Loss in Parkinson’s Models The authors explored the clinical utility of Miro1 for detecting Parkinson’s disease and for gauging potential treatments. [Cell Metab] Abstract | Press Release | Graphical Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Scientists showed that Zika virus-infected monocytes represent suitable carriers for viral dissemination to the central nervous system using human primary monocytes, cerebral organoids derived from embryonic stem cells, organotypic mouse cerebellar slices, a xenotypic human-zebrafish model, and human fetus brain samples. [Nat Commun] Full Article LanCL1 Promotes Motor Neuron Survival and Extends the Lifespan of Amyotrophic Lateral Sclerosis Mice Researchers report in vivo data using a transgenic SOD1G93A mouse model of ALS indicating that CNS-specific expression of lanthionine synthetase C-like protein 1 (LanCL1) transgene extended lifespan, delayed disease onset, decelerated symptomatic progression, and improved motor performance of SOD1G93A mice. [Cell Death Differ] Full Article Opcml-deficient mice displayed impaired cognitive behaviors and abnormal sensorimotor gating, which were similar to features in neuropsychiatric disorders such as schizophrenia. [Cell Rep] Full Article | Graphical Abstract Myelin-associated glycoprotein (MAG) induced apoptosis in developing cerebellar granule neurons through p75NTR signaling. Deletion of p75NTR in vivo reduced the number of apoptotic neurons in cerebellar white matter during development leading to reduction in the size of white matter in the adulthood. [Cell Death Dis] Full Article The authors investigated changes in protein expression of potential targets following mild traumatic brain injury using an in vivo controlled cortical impact model. [Cell Death Dis] Full Article XAF1, a tumor suppressor protein, paradoxically emerged as a mediator of differential plasticities towards adaptive resistance to temozolomide through epigenetic regulation. XAF1 promoted resistance both in vitro and in vivo. [Sci Rep] Full Article Scientists investigated the functional role of voltage-dependent anion-selective channel 1 (VDAC1) in the neurodegeneration triggered by spinal cord injury. [Sci Rep] Full Article The exosomes isolated from the supernatant of cultured MSCs could improve the functional recovery of spinal cord injury (SCI) rats by reducing SCI-induced neuron loss. [Gene Ther] Abstract Researchers evaluated the neuroprotective effect of three phytochemicals (sulforaphane, epigallocatechin gallate, and plumbagin) alone or in combination, focusing on their ability to counteract oxidative stress. The combined treatment was found to be more effective than the single treatments. [Antioxidants] Abstract | Full Article Download Subscribe to one of our other 19 science newsletters such as Cancer Stem Cell News & ESC & iPSC News. | |
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REVIEWSNAD+ in Brain Aging and Neurodegenerative Disorders The authors review emerging findings that reveal key roles for NAD+ and related metabolites in the adaptation of neurons to a wide range of physiological stressors and in counteracting processes in neurodegenerative diseases, such as those occurring in Alzheimer’s, Parkinson’s, and Huntington diseases, and ALS. [Cell Metab] Abstract Visit our reviews page to see a complete list of reviews in the neural cell research field. | |
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INDUSTRY NEWSTmunity Therapeutics, Inc. announced it has entered into an exclusive license and research collaboration agreement with Children’s Hospital of Philadelphia to advance a glypican 2 (GPC2) chimeric antigen receptor T-cell (CAR-T) therapy for the treatment of neuroblastoma, a rare cancer that affects the developing nervous system. [Tmunity Therapeutics, Inc.] Press Release Herantis Pharma Plc Provides Update on Timeline for Ongoing Phase I/II CDNF Trial Herantis Pharma Plc announced an update on the timeline for the ongoing Phase I/II clinical trial examining Herantis’ proprietary neuroprotective factor and novel drug candidate, CDNF, in patients with Parkinson’s disease. [Herantis Pharma Plc] Press Release New NIH-Funded Translational Research Centers to Speed, Diversify Alzheimer’s Drug Discovery To help meet the urgent need for therapies that will effectively treat or prevent Alzheimer’s disease, the National Institute on Aging has launched two new research centers with funding expected to total more than $73 million over the next five years. [National Institutes of Health] Press Release BrainStorm Cell Therapeutics Announces Support for FDA Guidelines on ALS Drug Development BrainStorm Cell Therapeutics Inc. supports the US FDA’s publication on September 24, 2019 of “Amyotrophic Lateral Sclerosis: Developing Drugs for Treatment Guidance for Industry.” [BrainStorm Cell Therapeutics Inc.] Press Release Immunomic Therapeutics, Inc. announced that it has assumed sponsorship of the Investigational New Drug (IND) application for ITI-1000 from the University of Florida. [Immunomic Therapeutics, Inc.] Press Release | |
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POLICY NEWSThese encouraging words were spoken here last week at the European Research and Innovation Days, where policy bigwigs working with the European Commission invited the audience to help shape Europe’s next seven-year research funding program, Horizon Europe, set to begin in 2021. Their message: Anyone can help “cocreate” the program’s outlines. [ScienceInsider] Editorial Trump Set to Nominate Stephen Hahn as FDA Commissioner, Pending Vetting Process President Trump is set to nominate Dr. Stephen Hahn to lead the FDA, pending completion of the vetting process, according to two people familiar with the selection process. Hahn, an oncologist, is the chief medical executive at MD Anderson Cancer Center in Houston. [STAT News] Editorial
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EVENTSNEW AACR-KCA Joint Workshop on Precision Medicine Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Scholar – Neural Precursor Cells (University of South Florida) Faculty Positions – Autism and Neurodevelopmental Disorders (University of South Carolina) Assistant/Associate Professor – Pediatric Brain Tumors (Baylor College of Medicine) Research Fellow – Neurodegenerative Disease (University College London) Faculty Positions – Brain Disorders (IDG/McGovern Institute for Brain Research) Postdoctoral Position – Neural Cell Research (New York Medical College) Postdoctoral Researcher – Neural Research (Flanders Institute for Biotechnology) Assistant Professor – Neurobiology (University of California, Berkeley) Postdoctoral Research Associate – Neural Stem Cell Research (St. Jude Children’s Research Hospital) Associate Research Scientist – Brain Research (Mortimer B. Zuckerman Mind Brain Behavior Institute) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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