Neural Cell News 14.00 January 8, 2020 | |
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TOP STORYInvestigators report methods for generating and biobanking patient-derived glioblastoma organoids that recapitulated the histological features, cellular diversity, gene expression, and mutational profiles of their corresponding parental tumors. [Cell] Abstract | Graphical Abstract | Press Release | |
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PUBLICATIONS(Ranked by impact factor of the journal)Outer Radial Glia-like Cancer Stem Cells Contribute to Heterogeneity of Glioblastoma Scientists found that multiple glia-like cancer stem cells (GSCs) subtypes existed within a single tumor. Within these GSCs, they identified an invasive cell population similar to outer radial glia, a fetal cell type that expanded the stem cell niche in normal human cortex. [Cell Stem Cell] Abstract | Graphical Abstract p120-Catenin-Dependent Collective Brain Infiltration by Glioma Cell Networks Researchers showed that glioma cells infiltrated the brain collectively as multicellular networks. Contacts between moving glioma cells were adaptive epithelial-like or filamentous junctions stabilized by N-cadherin, β-catenin and p120-catenin. [Nat Cell Biol] Abstract Glucocerebrosidase Activity Modulates Neuronal Susceptibility to Pathological α-Synuclein Insult Investigators examined the relationship between glucocerebrosidase activity and both pathogenic and non-pathogenic forms of α-synuclein in primary hippocampal, cortical, and midbrain neuron and astrocyte cultures, as well as in transgenic mice and a non-transgenic mouse model of Parkinson’s disease. [Neuron] Abstract | Graphical Abstract m6A mRNA Methylation is Essential for Oligodendrocyte Maturation and CNS Myelination The authors demonstrated that the oligodendrocyte lineage progression was accompanied by dynamic changes in N 6-methyladenosine modification on numerous transcripts. [Neuron] Abstract TREM2 Regulates Microglial Cholesterol Metabolism upon Chronic Phagocytic Challenge Researchers found that wild-type microglia acquired a disease-associated transcriptional state, while TREM2-deficient microglia remained largely homeostatic, leading to neuronal damage. [Neuron] Abstract | Graphical Abstract Differential Regulation of Autophagy during Metabolic Stress in Astrocytes and Neurons Scientists defined the molecular underpinnings of autophagy in primary cortical astrocytes in response to metabolic stress, and performed a comparative study in primary hippocampal neurons. [Autophagy] Abstract Researchers genetically modified the interferon regulatory factor (IRF)5 and IRF4 signaling to explore their roles in stroke. Both in vitro and in vivo assays were utilized; IRF5 or IRF4 siRNA, lentivirus, and conditional knockout techniques were employed to modulate IRF5 or IRF4 expression in microglia. [Proc Natl Acad Sci USA] Abstract The authors provided evidence that vacuolar protein sorting 35 (Vps35) in embryonic neurons was necessary for axonal and dendritic terminal differentiation. Loss of Vps35 in embryonic neurons resulted in not only terminal differentiation deficits, but also neurodegenerative pathology. [Cell Death Differ] Full Article Investigators performed a longitudinal study, using a combination of mathematical models, RNA sequencing, single cell analyses, functional and drug assays in a human glioma cell line. [Cell Death Dis] Abstract Scientists report that when used at appropriate concentrations, pharmaceutical inhibitors of BMI1 could efficiently prevent glioblastoma multiforme colony growth and cancer stem cell self-renewal in vitro and significantly extend lifespan in terminally ill tumor-bearing mice. [npj Precis Oncol] Full Article Subscribe to one of our other 19 science newsletters such as Cancer Stem Cell News & ESC & iPSC News. | |
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REVIEWSThe Future of Stem Cell Therapies for Parkinson Disease The authors critically assess the potential translational and clinical research trajectory of cell-replacement therapies that comprise dopamine neurons derived from human pluripotent stem cells and address its possibilities and current limitations. [Nat Rev Neurosci] Abstract Visit our reviews page to see a complete list of reviews in the neural cell research field. | |
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INDUSTRY NEWSATAI Life Sciences AG announced that it has partnered with Neuronasal Inc., to develop a short-term treatment for mild traumatic brain injury or concussion. [ATAI Life Sciences AG (PR Newswire, Inc.)] Press Release ESCAPE Bio, Inc., announced that ESB1609 demonstrated durable CSF pharmacokinetics and excellent safety and tolerability in a single ascending dose Phase I Study. ESB1609 is a novel, orally administered, brain-penetrant and highly-selective sphingosine 1-phosphate 5 receptor agonist. [ESCAPE Bio, Inc.] Press Release Mount Sinai Receives More than $10 Million in Grant Funding for Brain Tumor Research The Department of Neurosurgery at the Icahn School of Medicine at Mount Sinai has received more than $10 million in federal funding for several projects focusing on brain tumor research. [Mount Sinai] Press Release | |
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POLICY NEWSFrom Service to Science: NIH Shifts Focus of Mentoring Network Aimed at Boosting Grantee Diversity As co-director of graduate affairs at the University of Chicago, Nancy Schwartz spent the past four years helping faculty members at 15 major research universities become better mentors. The project was supported by the National Research Mentoring Network, a $23 million effort that the National Institutes of Health launched after discovering an embarrassing racial gap in who gets NIH grants. [ScienceInsider] Editorial UK Group Tackles Reproducibility in Research Last month, ten UK universities became part of the UK Reproducibility Network, joining a network that already includes stakeholders such as the Academy of Medical Sciences, Research Libraries UK, the National Institute for Biological Standards and Control, journals including Nature and PLOS, and local networks of researchers. [The Scientist] Editorial
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