Neural Cell News Volume 14.09 | Mar 11 2020

TOP STORY

Repopulating Microglia Promote Brain Repair in an IL-6-Dependent Manner

Scientists showed that removal of microglia from the mouse brain had little effect on the outcome of traumatic brain injury, but inducing the turnover of these cells through pharmacologic or genetic approaches could yield a neuroprotective microglial phenotype that profoundly aided recovery. [Cell] Full Article | Graphical Abstract

(Ranked by impact factor of the journal)

Sliced Human Cortical Organoids for Modeling Distinct Cortical Layer Formation

Researchers report on the sliced neocortical organoid system, which bypassed the diffusion limit to prevent cell death over long-term cultures. This method led to sustained neurogenesis. [Cell Stem Cell] Abstract | Graphical Abstract

Mutant ACVR1 Arrests Glial Cell Differentiation to Drive Tumorigenesis in Pediatric Gliomas

The authors demonstrated that Acvr1 ^G328V arrested the differentiation of oligodendroglial lineage cells, and cooperated with Hist1h3b ^K27M and Pik3ca ^H1047R to generate high-grade diffuse gliomas. [Cancer Cell] Abstract | Graphical Abstract

Pathogenic DDX3X Mutations Impair RNA Metabolism and Neurogenesis during Fetal Cortical Development

Severe DDX3X missense mutations profoundly disrupted RNA helicase activity, induced ectopic RNA-protein granules in neural progenitors and neurons, and impaired translation. [Neuron] Abstract | Graphical Abstract

Early Intraneuronal Amyloid Triggers Neuron-Derived Inflammatory Signaling in APP Transgenic Rats and Human Brain

The authors proposed that a plaque-independent inflammatory reaction originated from neurons burdened with increasing levels of soluble and oligomeric Aβ, which are known to be the most toxic amyloid species within the brain. [Proc Natl Acad Sci USA] Full Article

The FTLD Risk Factor TMEM106B Regulates the Transport of Lysosomes at the Axon Initial Segment of Motoneurons

Giant vacuoles specifically accumulated at the distal end and within the axon initial segment, but not in peripheral nerves or at axon terminals, resulting in impaired facial-nerve-dependent motor performance. [Cell Rep] Full Article | Graphical Abstract

Glioblastoma Cell Resistance to EGFR and MET Inhibition Can Be Overcome via Blockade of FGFR-SPRY2 Bypass Signaling

In glioblastoma cells treated with EGFR and MET inhibitors, SPRY2 expression was initially suppressed but eventually rebounded due to NF-κB pathway activation, resultant autocrine FGFR activation, and reactivation of ERK, which controlled SPRY2 transcription. [Cell Rep] Full Article | Graphical Abstract

Persistent Cyfip1 Expression Is Required to Maintain the Adult Subventricular Zone Neurogenic Niche

Scientist demonstrated that cytoplasmic FMRP-interacting protein (Cyfip1) expression was preferentially localized to B1 cells in the adult mouse subventricular zone. [J Neurosci] Abstract

MicroRNA-144 Represses Gliomas Progression and Elevates Susceptibility to Temozolomide by Targeting CAV2 and FGF7

MiR-144 was validated to have lower expression in glioma cell lines compared with cortical neuron cells by using qRT-PCR. [Sci Rep] Full Article

Impact of Neural Stem Cell-Derived Extracellular Vesicles on Mitochondrial Dysfunction, Sirtuin 1 Level and Synaptic Deficits in Alzheimer’s Disease

Researchers investigated the role of neural stem cell -derived extracellular vesicles in a transgenic mouse model of Alzheimer’s disease. [J Neurochem] Abstract

Subscribe to one of our other 19 science newsletters such as Cancer Stem Cell News & ESC & iPSC News.

Quiescent Neural Stem Cells for Brain Repair and Regeneration: Lessons from Model Systems

Non-mammalian vertebrates (zebrafish and salamanders) and invertebrates (Drosophila) offer insights into brain repair and quiescence regulation that are difficult to obtain using rodent models alone. [Trends Neurosci] Abstract

Visit our reviews page to see a complete list of reviews in the neural cell research field.

DelMar Pharmaceuticals Reports over 50% Enrollment in Phase II Clinical Trial of VAL-083 for Adjuvant Treatment of Brain Tumors

DelMar Pharmaceuticals, Inc. announced it has exceeded 50% enrollment in the adjuvant arm of the company’s ongoing Phase II clinical study investigating adjuvant treatment of MGMT-unmethylated glioblastoma multiforme with VAL-083. [DelMar Pharmaceuticals, Inc.] Press Release

Medicortex Finland Oy: Clinical Trial for Detection of Mild Traumatic Brain Injury in Children

Medicortex Finland Oy announced the start of a clinical trial for detection of mild traumatic brain injury and concussion. The company’s third clinical trial will focus on children and adolescents, and the recruitment of patients will take place at Satasairaala Hospital in Finland during the next few months. [Medicortex Finland Oy (BusinessWire, Inc.)] Press Release

Hundreds of Scientists Have Peer-Reviewed for Predatory Journals

Hundreds of scientists who post their peer-review activity on the website Publons say they’ve reviewed papers for journals termed ‘predatory’, an analysis has found. The site hosts at least 6,000 records of reviews for more than 1,000 predatory journals. [Nature News] Editorial

New Trump Rules Aim to Fuel Sharing of Patient Health Records by Smartphone

President Trump’s top health care aides said they will finalize federal rules requiring health providers and insurers to make health records available to patients in an easily accessible electronic format, a policy shift aimed at fueling broader efforts to use patient data to develop new software tools and services. [STAT News] Editorial

Clinical Research Company Sued over Stolen Trade Secrets after Employee Filmed Dogs Used in Experiments

Nearly two years ago, Charles River Laboratories paid $800 million for a company called MPI Research to bolster its business running clinical trials for drug makers and other companies. But Charles River did not know one MPI employee was an also undercover agent for the Humane Society of the United States and secretly filmed experiments conducted on various dogs, which were later publicized on the internet. [STAT News] Editorial

NEW Immunology 2020
May 8-12, 2020
Honolulu, Hawaii, United States

Visit our events page to see a complete list of events in the community.

NEW Research Assistant – Cerebral Organoids (Weill Cornell Medicine College)

Postdoctoral Fellow – Neuroscience Research (University of North Carolina at Charlotte)

Associate Professor – Visual Neuroscience (Dalhousie University)

Postdoctoral Associate – Traumatic Brain Injury (University of Miami)

Postdoctoral Fellow – Translational Brain Tumor Research (Northwestern University)

Branch Chief – Neuroscience Research (National Institutes of Health)

Postdoctoral Research Fellowship – Neuroscience and Stem Cells (Black Family Stem Cell Institute)

Faculty Position – Neuroimmunology (St. Jude Children’s Research Hospital)

Postdoctoral Research Positions – Alzheimer’s Disease and Traumatic Brain Injury (University of Colorado Boulder)

Postdoctoral Researcher – Neurodegenerative Diseases and Cancer (University of Pennsylvania)

Postdoctoral Associate – Neuron Diversity Mechanisms in Brain Development (Howard Hughes Medical Institute)

Faculty Positions – Brain Disorders (IDG/McGovern Institute for Brain Research)

Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.

Have we missed an important article or publication in Neural Cell News? Click here to submit!

Comments or suggestions? Submit your feedback here.